384 Hemoglobin: Allostery and Evolution Q5.1 - 2,3-BPG is a negative allosteric regulator of hemoglobin (Hb) oxygen binding.  Explain how elevated levels of 2,3-BPG in red blood cells at high altitude (14,800 ft above sea level) lead to more efficient delivery of O2 to the tissues considering that less O2 binds to Hb in the lungs under these conditions.

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Hemoglobin: Allostery and Evolution

Q5.1 - 2,3-BPG is a negative allosteric regulator of hemoglobin (Hb) oxygen binding.  Explain how elevated levels of 2,3-BPG in red blood cells at high altitude (14,800 ft above sea level) lead to more efficient delivery of O2 to the tissues considering that less O2 binds to Hb in the lungs under these conditions.

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