propose a retrosynthetic analysis for thefollowing moleculesN:Но4-chloro-6-methoxyquinazolin-7-olCOOMEНоmethyl 4-hydroxy-3-methoxybenzoate

"Since you have asked multiple questions, we will solve the first question for you. If you want any…

Answered: propose a retrosynthetic analysis for…

Science

Chemistry

propose a retrosynthetic analysis for the following molecules ÇI H3Ç N:

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter19: Enolate Anions And Enamines

Section: Chapter Questions

Problem 19.68P

See similar textbooks

Related questions

Q: *19. Following are the NMR spectra of three isomeric esters with the formula C;H14O2, all derived…

A: First we have to calculate the double bond equivalence (DBE) of the moleculer formula C7H14O2 by…

Q: Write the equation for the reaction of the following with acetaldehyde: a. 2,4-DNP b. Schiff's…

A: Since you have posted a question with multiple sub-parts, we will solve first three subparts for…

Q: Do a retrosynthetic analysis on the following compound, ending withavailable starting material.

A: In a retrosynthetic analysis, in order to prepare the target compound, the precursor is identified…

Q: H. エ-Z

A: This target compound is meta substituted benzene. So at first meta directing group has to be…

Q: Propose steps for the following conversions using a reaction of a diazonium salt in at least one…

Q: Addition of one equivalent of ammonia to 1-bromoheptane gives a mixture of heptan-1-amine,some…

A: (a)

Q: Apply retrosynthetic analysis to identify all the practical combinations of Grignard reagent and…

A: Since you have posted a question with multiple sub-parts, we will solve first three subparts for…

Q: (a) Discuss the synthesis of 1,3-thiazole derivative from thioamide and an a-haloketone.

Q: Benzene magnesium bromide (Grignard reagent) reacts with acetaldehyde in diethyl ether to produce a…

Q: HO H;O, 0-10 °C OH 2.

Q: Given this retrosynthetic analysis, propose a synthesis for the antidepressant moclobemide. CI H CI…

Q: Consider the following reaction schemes involving the reaction of an imine with an organolithium…

A: Lithium halogen exchange reaction :

Q: Asteltoxin, isolated from cultures of Aspergillus stellatus, exhibits a potent inhibitor on E. coli…

A: Given:- Asteltoxin, isolated from cultures of Aspergillus stellatus, exhibits a potent inhibitor on…

Q: Propose a synthesis for compound 1 (in the box I show how the molecule should be disconnected as a…

A: Multi step synthesis:

Q: 14 1. Suggest a reason why this might be considered a good point for a first disconnection. II.…

A: DCC is used to convert carboxylic acid to amide in the presence of the base. General reaction is…

Q: IV. Arrange the following in ascending order of reactivity for the preparation of the corresponding…

A: The given salicylaldehyde are to be arrange in ascending order of reactivity for the preparation of…

Q: Question is attached

A: An acid is a substance that can furnish hydrogen ions in an aqueous solution. When the dissociation…

Q: Provide a retrosynthetic analysis and a synthesis of amino acid D, using 3- chlorobenzaldehyde as…

A: Please find the attachment.

Q: Spasmolytol, as its name suggests, is an antispasmodic. Given this retrosynthetic analysis, propose…

A: Spasmolytol is an antispasmodic drug that used to relieve the pain of involuntary muscle. Salicylic…

Q: he starting material, intermediates, and product of the reduction of benzil using sodium prohydride…

A: Various syntheses are studied in organic chemistry. Some useful techniques like NMR are used to…

Q: How will you carry out the purification of dibenzalacetone by recrystallization? Propose a procedure…

A: Purification is process of separation of chemical substances from impurities. Recrystallization is…

Q: a) Devise a synthesis of the target molecule 8. Simple starting materials with seven or less carbon…

Q: Starting with benzene, outline a procedure for synthesizing m-chloroaniline.

A: Dear student I have given answer to your question in the image format.

Q: Treatment of a carboxylic acid with triflwergacetic anhydride leads to an unsymmetrical anhydride…

A: unsymmetrical anhydride and ester are formed by reaction of nucleophilic addition to carbonyl group.…

Q: Based on this retrosynthetic analysis, propose a synthesis of the anticoagulant (a substance that…

A: Diphenadione can be produced from the retrosynthetic reaction of diethyl pthalate and the given…

Q: 13) Propose a synthesis of compound 47 using the chemicals in the box. 47 РСС HBr Mg H2O

Q: Show how any ONE the following would be made through use of a Grignard in as few steps as possible,…

A: We can design the synthetic pathway for the desired product by properly placing the partial charges…

Q: Find out the structure of compound 3 in the following multistep synthesis. DIBAL-H PPh3 HẠN-NH OMe 1…

A: In this question we have to tell the product of the reaction of the sequence.

Q: H. Z-エ

A: This reaction can be started with convertion of benzene to nitrobenzene.

Q: propose a retrosynthetic analysis for the following molecules HO 4-chloro-6-methoxyquinazolin-7-ol…

A: The retrosynthesis of the given compounds are :

Q: C) Suggest chemical method to synthesis compound (2) from compound (1). (0-CH2 Q-CH; C'H;CH÷=CH, Сно…

A: The reaction of an alkene with ozone followed by the reaction of the intermediate with the reducing…

Q: Give the products expected when acetic formic anhydride reacts with (i) aniline and(ii) benzyl…

A: The mechanism for the reaction between acetic formic anhydride and aniline is as follows

Q: Propose a synthesis for 18-crown-6. If a base is used in your synthesis, does it make a difference…

Q: Do a retrosynthetic analysis on the following compound, ending withavailable starting material.

A: A species with a larger size can easily accommodate negative charge. In other words, in a large size…

Q: Propose a structure for a compound A that has an infrared absorption at 1820 cm- and a single proton…

A: Given is , information of compound A.

Q: Using the "Basic" toolbox on OscerSyn, propose a synthesis of the following compound using reactants…

A: The synthesis method for the given compound has been described below.

Q: 二ニ。二二人 HO, んこんーん HO.

A: N. Amide to amine using LiAlH4. O. Acid chloride reaction with amine (Acyl substitution). P. Acid is…

Q: 4 Suggest the retrosynthetic analysis of Decane CH-(CH))s-CHs

A: It is a technique ofchemical synthesis by involving deconstructing a target molecule into readily…

Q: NH CH3 N-benzylacetamide

Q: b) Compound E with a molecular formula of CAH&O gives a positive iodoform test. он H3C. NABH4 E CH3…

A: NaBH4 is reducing agent...it specifically reduce aldehyde and ketone into respective alcohol...…

Q: Predict the product of the reaction of p-methylbenzoic acid with each of the following: (a) LiAlH4,…

Q: Indene NH4Br, KHSO5, CH3CN:H₂O Br OH or "Bromoindanol" OH Br You will determine the structure of…

A: This occur via bromonium intermidiate

Q: Devise a synthesis of the target molecule 8. Simple starting materials with seven or less carbon…

Q: of 1. DIBAL-H OCH,CH, 2. H;O* CH3CH2NH2 Br 1. CH,MgBr 2. H,0* CH3NH2 ned with CamScanner

A: ->There is electrophilic centre in acid derivatives hence they give nucleophilic addion…

Concept explainers

NMR Spectroscopy

NMR stands for Nuclear Magnetic Resonance in which the study of different molecules is done based on the interaction of radiofrequency electromagnetic radiations with the nuclei of molecules placed in a strong magnetic field. A precise study of spectra of visible light and all bands of electromagnetic radiation is called spectroscopy.

Question

propose a retrosynthetic analysis for the
following molecules
N:
Но
4-chloro-6-methoxyquinazolin-7-ol
COOME
Но
methyl 4-hydroxy-3-methoxybenzoate

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 2 steps with 1 images

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

The following scheme shows the retrosynthetic analysis of 1-isopentylaziridine to formseries of intermediates via Functional Group Inversion (FGI). Choose the correct reagentsof N-S for the respective conversion from the given list of reagents.
In an aqueous solution containing sodium bicarbonate, aniline reacts quickly withbromine to give 2,4,6-tribromoaniline. Nitration of aniline requires very strong conditions,however, and the yields (mostly m-nitroaniline) are poor. *(c) Although nitration of aniline is slow and gives mostly meta substitution, nitrationof acetanilide (PhNHCOCH3) goes quickly and gives mostly para substitution. Useresonance forms to explain this difference in reactivity.
Reaction of (CH3)3CCHO with (C6H5)3P=C(CH3)OCH3, followed bytreatment with aqueous acid, affords R (C7H14O). R has a strong absorption in its IR spectrum at 1717 cm−1 and three singlets in its 1H NMR spectrum at 1.02 (9 H), 2.13 (3 H), and 2.33 (2 H) ppm. What is thestructure of R?
Reaction of p-cresol with two equivalents of 2-methylprop-1-ene affordsBHT, a preservative with molecular formula C15H24O. BHT gives thefollowing 1H NMR spectral data: 1.4 (singlet, 18 H), 2.27 (singlet, 3 H), 5.0(singlet, 1 H), and 7.0 (singlet, 2 H) ppm. What is the structure of BHT?Draw a stepwise mechanism illustrating how it is formed.
In an aqueous solution containing sodium bicarbonate, aniline reacts quickly withbromine to give 2,4,6-tribromoaniline. Nitration of aniline requires very strong conditions,however, and the yields (mostly m-nitroaniline) are poor.(a) What conditions are used for nitration, and what form of aniline is present under theseconditions?
Undecanal is commercially available, but 6-methyl-1-bromoheptane is not. Propose two methods for the synthesis of 6-methyl-1-bromoheptane using precursors containing fewer than five carbon atoms (Cn n < 5). A protecting group will probably be required.
The following equation shows the reaction of trans-2,3-diphenyloxirane with hydrogen chloride in benzene to form 2-chloro-1,2-diphenylethanol. (a) How many stereoisomers are possible for 2-chloro-1,2-diphenylethanol? (b) Given that opening of the epoxide ring in this reaction is stereoselective, predict which of the possible stereoisomers of 2-chloro-1,2-diphenylethanol is/are formed in the reaction.
Treatment of an aldehyde or ketone with cyanide ion (-:C=N), followed by protonation of the tetrahedral alkoxide ion intermediate, gives a cyanohydrin. Show the structure of the cyanohydrin obtained from cyclohexanone.
Show the products from reaction of p-bromoaniline with the following reagents: (a) CH3I (excess) (b) HCl (c) HNO2, H2SO4 (d) CH3COCl (e) CH3MgBr (f) CH3CH2Cl, AlCl3 (g) Product of (c) with CuCl, HCl (h) Product of (d) with CH3CH2Cl, AlCl3
When cis-2-decalone is dissolved in ether containing a trace of HCl, an equilibrium is established with trans-2-decalone. The latter ketone predominates in the equilibrium mixture. Propose a mechanism for this isomerization and account for the fact that the trans isomer predominates at equilibrium.
What starting materials are needed to prepare the compound below by intramolecular Michaelreaction?
Using appropriate diagrams draw full retrosyntheticschemes for the synthesis of the following targetmolecule (Figure Q15d). Your retrosynthesisshould lead back to acetone (propanone) andN,N- dimethylaniline (N,N-(dimethylamino)benzene). You should includedisconnections, retrosynthetic arrows, synthonsand synthetic equivalents. You should alsocomment on any selectivity issues asappropriate. Target molecule