Question # 1: Design a suitable synthesis plan for the preparation of 2-cyclohexylacetic acid starting with cyclohexanol (Hint: One of the possible reagents can be oxirane). HO. cyclohexanol 2-cyclohexylacetic acid

Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter16: Aldehydes And Ketones
Section: Chapter Questions
Problem 16.47P: The base-promoted rearrangement of an -haloketone to a carboxylic acid, known as the Favorskii...
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Question # 1: Design a suitable synthesis plan for the preparation of 2-cyclohexylacetic acid starting with
cyclohexanol (Hint: One of the possible reagents can be oxirane).
он
HO
cyclohexanol
2-cyclohexylacetic acid
Question # 2: Suggest an appropriate forward synthesis for the preparation of 4-hydroxy-4-methylpentan-2-one
using 2-methylpropane-1,2-diol and acetyl chloride (Hint: think of protection/de-protection strategy).
но.
но.
HO
4-hydro xy-4-methylpentan-2-one 2-methylpropane-1,2-diol
+
TCI
acetyl chloride
Transcribed Image Text:Question # 1: Design a suitable synthesis plan for the preparation of 2-cyclohexylacetic acid starting with cyclohexanol (Hint: One of the possible reagents can be oxirane). он HO cyclohexanol 2-cyclohexylacetic acid Question # 2: Suggest an appropriate forward synthesis for the preparation of 4-hydroxy-4-methylpentan-2-one using 2-methylpropane-1,2-diol and acetyl chloride (Hint: think of protection/de-protection strategy). но. но. HO 4-hydro xy-4-methylpentan-2-one 2-methylpropane-1,2-diol + TCI acetyl chloride
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