Question 7 The uncoupling agent 2,4-dinitrophenol (DNP) has a pk, of about 7.2. Which of the following describes how this molecule works to uncouple the proton gradient? NO2 O2N- 2,4-Dinitrophenol (DNP)

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Question 7
The uncoupling agent 2,4-dinitrophenol (DNP) has a pką of about 7.2. Which of the
following describes how this molecule works to uncouple the proton gradient?
NO2
O2N-
2,4-Dinitrophenol (DNP)
DNP is initially protonated in the intermembrane space, then deprotonated
after crossing to the matrix, thus dissipating the proton gradient.
DNP is initially deprotonated in the intermembrane space, then protonated
after crossing to the matrix, thus dissipating the proton gradient.
O c) None of the answers is correct.
DNP is initially deprotonated in the matrix, then protonated after crossing to
the intermembrane space matrix, thus dissipating the proton gradient.
DNP is initially protonated in the matrix, then deprotonated after crossing to
the intermembrane space matrix, thus dissipating the proton gradient.
Transcribed Image Text:Question 7 The uncoupling agent 2,4-dinitrophenol (DNP) has a pką of about 7.2. Which of the following describes how this molecule works to uncouple the proton gradient? NO2 O2N- 2,4-Dinitrophenol (DNP) DNP is initially protonated in the intermembrane space, then deprotonated after crossing to the matrix, thus dissipating the proton gradient. DNP is initially deprotonated in the intermembrane space, then protonated after crossing to the matrix, thus dissipating the proton gradient. O c) None of the answers is correct. DNP is initially deprotonated in the matrix, then protonated after crossing to the intermembrane space matrix, thus dissipating the proton gradient. DNP is initially protonated in the matrix, then deprotonated after crossing to the intermembrane space matrix, thus dissipating the proton gradient.
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