Ribosome ER signal xaquence Ass pokpeptidea being muda SRP bindtan ER signial sequence nd caum traralation to paun. SRP binda to an SAP receptor in the ER membrane, which a located nast toa channel. Forthis binding to oce, proteira within SRP wnd the SRP recaptor mut abo be bound by GTP. Cytomal ER membran ER lumen Charnel SRP receptor The GTPbinding proteina wthin SRP nd the SRP recaptor hydralyre their CTP, Caing the relemn of SRP. The lowa trunalation to reauma, and the polypeptide i threded through channal nto the ER lumen FIGURE 17.6 Tarwting of paypeptites lo the endoplamt retkulum mentrae via SRP. Ineukaryoes, ve ral categories of proicins are fiest largeled to the IR membrane via SRP. These include ecreied proleins z well as proleins that are destined to stay in the ER, Golgi apparatus, lysosomes, or vacuoles.
Ribosome ER signal xaquence Ass pokpeptidea being muda SRP bindtan ER signial sequence nd caum traralation to paun. SRP binda to an SAP receptor in the ER membrane, which a located nast toa channel. Forthis binding to oce, proteira within SRP wnd the SRP recaptor mut abo be bound by GTP. Cytomal ER membran ER lumen Charnel SRP receptor The GTPbinding proteina wthin SRP nd the SRP recaptor hydralyre their CTP, Caing the relemn of SRP. The lowa trunalation to reauma, and the polypeptide i threded through channal nto the ER lumen FIGURE 17.6 Tarwting of paypeptites lo the endoplamt retkulum mentrae via SRP. Ineukaryoes, ve ral categories of proicins are fiest largeled to the IR membrane via SRP. These include ecreied proleins z well as proleins that are destined to stay in the ER, Golgi apparatus, lysosomes, or vacuoles.
Biology: The Unity and Diversity of Life (MindTap Course List)
15th Edition
ISBN:9781337408332
Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Chapter9: From Dna To Protein
Section: Chapter Questions
Problem 1DAA: RIPs as Cancer Drugs Researchers are taking a page from the structure-function relationship of RIPs...
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Question
Look at the figure and predict what would happen if the SRP
RNA was unable to stimulate the GTPase activities of the GTPbinding
proteins within SRP and the SRP receptor.
Expert Solution
Step 1
A specific ribonucleoprotein serves the function of recognition and targeting of the protein to the endoplasmic reticulum and plasma membrane of the eukaryotes and prokaryotes respectively and this ribonucleoprotein is known as the signal recognition particle (SRP). Besides, it is abundant, cytosolic, and conserved universally.
GTP on the other hand is associated with the transcription process and also acts as the building blocks during RNA synthesis.
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