Search for a structure of one common drug that is available locally. Draw the structure of the drug and label the functional group/s found on the structure. You can use different color of pen if you wish to. Place it on a clean paper. Search for the metabolic of that particular drug, identify which Phase 1 or phase 2 metabolism it will undergo by illustrating the metabolite after metabolism. Make a brief discussion about it - handwritten - please write legibly,
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Search for a structure of one common drug that is available locally.
Draw the structure of the drug and label the functional group/s found on the structure. You can use different color of pen if you wish to. Place it on a clean paper.
Search for the metabolic of that particular drug, identify which Phase 1 or phase 2
Make a brief discussion about it - handwritten - please write legibly,
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- Suicide substrates are substances that resemble the substrate,but when incorporated into the active site they form a covalent bond with the enzyme, permanently inhibiting it. Thesemolecules have been used to label the amino-acid side chainsthat are involved in the catalytic reaction occurring withinthe active site. This is usually accomplished by hydrolyzingthe inhibited enzyme. How could an investigator identify theamino acid bound to the suicide substrate molecule?A biochemical reaction transfers 60 kJ mol-1(15 kcal mol-1) of energy. What general process most likely wouldbe involved in this transfer? What cofactor (or cosubstrate) likelywould be used? Which cofactor probably would not be used?The structure of a metalloenzyme active site is down below(black picture). Describe, from a chemical and structural perspective, how the reactive site is designed to facilitate its catalytic reaction. The example below(white pitcure) suggests the level of detail that is required. Make sure that you explain what the metal is doing, what the reaction is, and its biological significance.
- With appropriate chemical structures, explain the mechanism (mode-of-action) of fluoroacetate poisoning? Example: Step 1: Fluoroacetate is converted to Product “A”. This reaction is catalyzed by Enzyme __________________________ Structures of fluoroacetate and the product “A”. Name of Enzyme. Step 2: Product “A” from Step 1 is converted to Product “B.” Catalyzed by enzyme 2. Structure of Product B and name of Enzyme 2. etc.Integration of Metabolism Complete the interrelated pathways by providing the necessary metabolite, enzyme, and reaction or metabolic pathway. Abbreviations and acronyms for pathways, metabolites, products and enzymes will not be accepted (For coenzymes, you may use abbreviations/acronyms). Fill the blank in numbers 1-20The structure of a metalloenzyme active site is down below(black picture). Describe, from a chemical and structural perspective, how the reactive site is designed to facilitate its catalytic reaction. The example below suggests the level of detail that is required. Make sure that you explain what the metal is doing, what the reaction is, and its biological significance.
- The metabolism of alcohol pathway is showed in the figure characterized by biotransformation of: (Figure : Ethanol Metabolism Pathway - ADH : Alcohol dehydrogenases, ALDH: Aldehyde dehydrogenase ) (a) reaction phase I with two oxidations (b) reaction phase II with oxidation and sulfonation (c) reaction phase II with two hydrolysations (d) reaction phase II with two oxidations (e) reaction phase I with hydrolysis and oxidationDraw the structure before the product of glucose react further, how does oxidation occur in glucose? Please draw and explainHello, For the image included: A) Which of the following statements are true of the malate dehydrogenase reaction in biochemical standard conditions? Choose all that apply. Group of answer choices: The reaction is spontaneous since ∆G°' is positive The reaction is spontaneous since ∆G°' is negative The reaction is not spontaneous since ∆G°' is positive The reaction is not spontaneous since ∆G°' is positive The equilibrium favors products since K is greater than 1 The equilibrium favors reactants since K is greater than 1 The equilibrium favors products since K is less than 1 The equilibrium favors reactants since K is less than 1 The reaction is always at equilibrium B) If the concentration of oxaloacetate is 107 times lower than the concentration of malate. Is the reaction spontaneous? Assume biochemical standard conditions. Group of answer choices No, because RTlnQ is very positive Yes, because RTlnQ is very positive No, because RTlnQ is very…
- a. Provide names for both metabolites. b. What kind of reaction occurs here? c. What enzyme performs this reaction? d. What cofactors (if any) are involved in this reaction? ***please help with this homework problem!!!***Complete the following tables by providing the reactants/substrates, enzymes and their functions as well as the products in each step of the fatty acid synthesis. PS Same question was already answered in bartleby, I reasked this question to validate if the answer is correct. PSS Please provide the structure of the REACTANTS and PRODUCTS PSSS Not a graded questionWhat are enzymes? What distinguishes enzymes from regular chemical catalysts? On the specificity of enzyme action, please comment. Which factor accounts for their specificity the most? Describe the enzyme catalysis mechanism.