Consider a peptide with the following amino acid sequence: H2N-ASENHLDGCPYTKSRG-COOH Analyze the predominate protonation state and thus dominate charge (+1, 0, -1) of the residues in this peptide at pH 3, 6, and 10 by filling in the table below, identifying the relevant pKa appropriate for each residue. (Note that choice of pKa and its. application will be graded independently; e.g., if you can choose the wrong pKa but apply it correctly, you will lose points only for the pKa.) AA Residue pKa Charge pH 3 Charge pH 6 Charge pH 10 A         S         E         N         H         L         D         G         C         P         Y         T         K         S         R         G

Biology 2e
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Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter3: Biological Macromolecules
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Chemistry

Consider a peptide with the following amino acid sequence:

H2N-ASENHLDGCPYTKSRG-COOH

Analyze the predominate protonation state and thus dominate charge (+1, 0, -1) of the residues in this peptide at pH 3, 6, and 10 by filling in the table below, identifying the relevant pKa appropriate for each residue. (Note that choice of pKa and its. application will be graded independently; e.g., if you can choose the wrong pKa but apply it correctly, you will lose points only for the pKa.)

AA Residue

pKa

Charge pH 3

Charge pH 6

Charge pH 10

A

       

S

       

E

       

N

       

H

       

L

       

D

       

G

       

C

       

P

       

Y

       

T

       

K

       

S

       

R

       

G

       
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