Sickle-cell anemia is a genetic disorder of individuals homozygous for a mutation of hemoglobin that causes their red blood cells to be sickle shaped and stiff under conditions of low pO2. Why is this disease life threatening?

Sickle-cell anemia is a genetic disorder of individuals homozygous for a mutation of hemoglobin that causes their red blood cells to be sickle shaped and stiff under conditions of low pO2. Why is this disease life threatening?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section10.7: Defects In Transport Proteins: Hemoglobin

Problem 1EG

See similar textbooks

Related questions

Q: ABO blood types are determined by three alleles of one gene?

A: The blood in an individual can be separated based on the presence or absence of specific blood type…

Q: Using hemophilia as an example, discuss how mutations, genetics, and history interact in real-life…

A: Hemophilia It is a common hereditary coagulation blood disorder due to the deficiency or reduced…

Q: Explain why a woman carrying the gene forhemophilia can produce two hemophiliac sonswhen she is…

A: A disorder in which blood doesn't clot normally because of a lack of sufficient blood-clotting…

Q: a) Arlene is blood type B. Her mate Garfield is blood type O. What blood type(s) of kittens might…

A: A blood classification (otherwise called a blood bunch) is an arrangement of blood, in light of the…

Q: Hematopoietic stem cells in the bone marrow of adults .. O a) are multipotent, in that they can…

A: Introduction Hematopoietic stem cells:- It is an immature cell that can develop into all types of…

Q: Give the genotypes of each of the following blood types: A, B, O, AB. What happens when a person…

A: A gene is a stretch of nucleotides present in the DNA. DNA or deoxyribonucleic acid is a polymer of…

Q: A mother with blood type A has a child with blood type B. What blood type(s) would a man have to…

A: Humans follow ABO blood group system in which three genes are responsible for determining the blood…

Q: in horses, a classic champagne colored horse and an amber champagned colored horse produce a golden…

A: Introduction :- The horse is a domesticated, hoofed mammal with unusual toes. It is one of the two…

Q: According to an old celebrity rumor, L' nel Ritchie is Khloe Kardashian's dad. If Khloe were type O…

A: Khloe Kardashian is type O blood group, which means she have two alleles of IO (genotype IOIO). Now,…

Q: A phenotypically normal man, who has a hemophiliac brother, marries a normal woman, who is not a…

A: Hemophilia is an X-linked recessive disorder so, an individual inherits this disease from his mother…

Q: Hereditary hemochromatosis is an autosomal recessive genetic disorder that causes the body to absorb…

A: Mutations are alterations in the DNA sequence of an organism. Small changes, such as adding or…

Q: Sickle cell anemia is an inheritable red blood cell disorder that results in sickle-shaped red blood…

A: HbA encodes normal phenotype. This allele is dominant over HbS allele.

Q: Two people, both with AB blood have four children. What blood types should the children be?

A: Sir Gregor Mendel was a priest and a teacher who did the famous hybridization experiment on garden…

Q: True or False: An individual with sickle-cell anemia is caused by a missense mutation.

A: Missense mutation is a type of genetic alteration in which a single base pair substitution alter…

Q: The human blood alleles for both A and B blood, when expressed together are referred to as

A: An allele is a variant form of a given gene. It is one of two or more versions of a known mutation…

Q: The likelihood that a son of a patient with severe hemophilia A will have hemophilia is

A: Hemophilia There are three types of hemophilia. Hemophilia A: It is caused by clotting factor VIII…

Q: I read that vinyl chloride exposure is associated with an increased risk of a rare form of liver…

A: Cancer is the condition of uncontrolled cell division.

Q: Astigmatism and polydactyly are dominant over normal vision and finger traits. Sickle-cell anemia on…

A: Dominant character is always expressed either in the heterozygous or homozygous form where as the…

Q: Sickle anemia is a favorable mutation. There is only one amino acid different in sickle haemoglobin…

A: Sickle cell anemia is genetic disease in which blood cells contort into a sickle shape. RESULTS- 1.…

Q: Jacob and Patau Syndromes List the similarities and differences between these two syndromes. Which…

A: Jacob syndrome: Also known as XYY syndome/ XYY karyotype/ YY syndrome Patau syndrome: Also known as…

Q: Define a Point mutation and give an example. What is sickle cell anemia and what causes it. What…

A: Mutation refers to the phenomena in which the structure of a gene or DNA sequence changes, resulting…

Q: A woman with blood type B has a child with blood type O. Her husband, whose blood type is A is…

A: The ABO blood group genetics is very good example of multiple allelism and co-dominance. The blood…

Q: Why doesn't sickle cell anemia "prove" the existence of biological race?

A: *sickle cell Anaemia is a inherited blood disorder *This disease produce abnormal haemoglobin in…

Q: Maria (AA-) and Jason (AB+) Phillips had twins, a boy and a girl. Lily (AO-) and Charles (AO-) Smith…

A: The ABO blood group system is present in the human. There are four blood groups in the ABO blood…

Q: A child has a blood type O. His mother has blood type O, and his father has blood type AB. Provide…

A: There are four types of blood group found in humans viz. O, A, B and AB.

Q: t is the Philadelphia chromosome? Briefly describe how it causes chronic myeloid leukemia.

A: A chromosome is a dna (deoxyribonucleic acid) molecule that contains some or all of an organism's…

Q: Can a child have blood group O if his parents have 'A' and 'B'.explain.

A: Introduction: Blood type or blood group is a classification system defining the presence or absence…

Q: here is a benign congenital condition called Hereditary Persistence of Fetal Hemoglobin (HPFH) in…

A: Hereditary Persistence of Fetal Hemoglobin is the condition when there is still fetal hemoglobin…

Q: What is sickle cell anemia? What is the true inheritance pattern? How did scientists discover the…

A: ▪︎Sickle cell anemia is a disease in which the body produces abnormally shaped red blood cells that…

Q: Human blood types are genetically determined. A male and a female both have blood type AB. If they…

A: In humans, the blood group is of four types A, AB, B, and O. All these are determined genetically.…

Q: A woman sues a man for the support of her child. She has type A blood, her child has type O, and the…

A: Q.4 The man can be the father of the child because they produce O blood type group child also.

Q: Describe the inheritance of the ABO blood group

A: The ABO blood group system is determined by the ABO gene present on chromosome 9. There are four…

Q: Astigmatism and polydactyly are dominant over normal vision and finger traits. Sickle-cell anemia on…

A: Astigmatism is an eye disease where the curvature of the cornea or the lens is affected, leading to…

Q: there is less oxygen in the air high above sea level, such as in the mountains. as a result, the…

A: Air is composed of various molecules with Nitrogen, being the most abundant element and Oxygen, the…

Q: Four children have the following blood types: A, B, AB, and O. Could these children have the same…

Q: Mr. and Mrs. Smith are concerned because their own blood types are A and B, respectively, but their…

A: Given: Mr Smith has A blood type Mrs Smith has B blood type Richard, their son has O blood type.…

Q: What are the 3 alleles of the gene that control blood type? A. IA IB i B. A B O C. IA IA IBI

A: ABO blood group system is the classification of human blood groups according to the inherited…

Q: Homer Simpson goes to the hospital to run some tests. The doctors there ask him what his blood type…

A: The antigens on the erythrocyte surface are important determinants for the transfusion of blood. The…

Q: IAIB people have type AB blood because the A and B alleles demonstrate

A: The human blood grouping a system which classifies blood into A , B and O groups.

Q: An A+ male impregnates a woman who is unsure of her blood type. Which blood type would the mother…

A: The risk primarily occurs because mother`s blood somehow does not match his baby`s blood group, as a…

Q: . A young woman in Hollywood sued a famous movie actor for support of her child, claiming that he…

A: Blood group phenotype in humans is controlled by multiple alleles, i.e., there are more than 2…

Q: Luanne (AA-) and Hank (AB+) Phillips had twins, a boy and a girl. Maya (AO-) and Sam (AO-) Smith had…

A: In case of human ABO+/- blood grouping, the alleles A and B are codominant while they are both…

Q: Two people with type O blood have three children. How many of those three children also have type O…

A: People with type O blood group have genotype ioio so, these both individual will have ioio genotype.…

Q: A woman with type B blood has a child with type O blood. Whatare the possible genotypes and blood…

A: According to the question, a woman is blood type B and has a child with blood type O but her…

Q: The mutation causing sickle-cell anemia in humans, which changes the normal T to an A in the sixth…

A: Hemoglobin is a normal globin protein with heme (iron) in the red blood cells. It helps to…

Q: A man type ab blood marries a woman with type b blood whose father has type o blood. What are the…

A: Blood is a body fluid that carries necessary nutrients and oxygen to the cells and transports…

Q: Blood types in humans are Codominant. a. What are the possible genotypes of someone with type O…

A: Answer: CO-DOMINANCE = It is the cross between those alleles that lacks the dominant and recessive…

Q: Why is sickle-cell anemia life-threatening

A: Introduction Genetic disorders are those that are inherited from the parents to the next generation.…

Concept explainers

Hematology

Hematology is the branch of biology. Hematology is the medical field that deals with the treatment of blood disorders and cancers, such as hemophilia, leukemia, lymphoma, and sickle-cell anemia. Hematologists and hematopathologists are medical professionals who specialize in illnesses of the blood and its components.

Question

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions

Why is sickle-cell anemia life-threatening? if Sickle-cell anemia is a genetic disorder of homozygous for a mutation of hemoglobin that causes their red blood cells to be sickle shaped and stiff under conditions of low pO2.
True or False: An individual with sickle-cell anemia is caused by a missense mutation.
The group of disorders associated with single gene mutations affecting amino acid sequences in the alpha and beta globin genes are called Question 10 options: A) thalassemias B) hemoglobinopathies C) hemolytic anemias D) megaloblastic anemias
what fraction of the offspring of two parents with sickle trait would you expect to have sickle cell anemia? Explain how you arrived at this answer. Also include a punnet square
One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood disorder in which red blood cells are abnormally shaped and fragile, leading to a short supply of red blood cells. These abnormal cells can also get stuck in small vessels, which prevent blood flow, leading to fatigue, pain, and other severe complications. Patients with sickle cell anemia produce defective beta-globin due to a point mutation that causes the change of a single amino acid residue. This is an example of what type of mutation? nonsense mutation missense mutation frameshift mutation deletion mutation
Sickle-cell disease (often called sickle-cell anemia) is a disease that is caused by a mutation to the gene that is responsible for producing the protein hemoglobin. Remember that hemoglobin is a protein in the red blood cells which is responsible for carrying oxygen throughout the body. When a person possesses the mutated hemoglobin allele, their red blood cells take on an altered shape and this results in a variety of symptoms ranging from general weakening of the body, damage to the organs and even death. The sickle cell allele is recessive to the healthy allele, thus only individuals that are homozygous for the recessive allele will have sickle-cell disease. Individuals that are homozygous for the healthy allele, along with heterozygous, individuals will be physically healthy. Question: Given that this mutated allele will cause disease and death in individuals, what would you predict to occur to the frequency of this allele in the population? Explain.
Describe the genetic and molecular basis of sickle-cell anemia.
What advantage do people with sickle cell trait have? How is this advantage responsible ofpeople in certain areas of the world having high rates of Sickle cell anemia ?
Sickle cells are named because of their characteristic shape. What problems can this shape cause? Explain how the absence of a nucleus affects a red blood cell’s life span.
Define a Point mutation and give an example. What is sickle cell anemia and what causes it. What is nondisjunction? How does nondisjunction cause disorders? NUMER YOUR ANSWERS
One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood disorder in which red blood cells are abnormally shaped and fragile, leading to a short supply of red blood cells. These abnormal cells can also get stuck in small vessels, which prevent blood flow, leading to fatigue, pain and other severe complications. If your patient's parents decide to have another child, what is the chance that that child will also have sickle cell anemia? 0% 25% 50% 75% 100%
What are the conditions under which hemoglobin precipitates out of solution, and how are normal and sickle-cell hemoglobin different in that regard? What do you predict will happen to red blood cells if hemoglobin precipitates out of solution and crystallizes?