Why is sickle-cell anemia life-threatening

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter10: From Proteins To Phenotypes
Section10.7: Defects In Transport Proteins: Hemoglobin
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Why is sickle-cell anemia life-threatening? if Sickle-cell anemia is a genetic disorder of homozygous for a mutation of hemoglobin that causes their red blood cells to be sickle shaped and stiff under conditions of low pO2. 

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