Sickle cell disease results from a point mutation of the ______. α-globin of guanine for glutamine β-globin of valine for glutamate β-globin of histidine for glycine γ-globin of proline for tyrosine γ-globin of glutamate for guanine
Q: Which of the following applies to Sickle Cell Anemia? Choose all that apply. Group of answer choices…
A: The blood is chronically low in oxygen during the disease of sickle cell anaemia. The symptoms of…
Q: Why is it important that cell surface markers be similar when transplanting donor tissue into a…
A: Human leukocyte antigen (HLA) typing is used to match patients and donors for organ transplants. Our…
Q: Glutamic acid (Glu) is encoded by GAA and GAG, while Glutamine (Gln) is encoded only by CAA and CAG.…
A: The base sequence provided in the picture given in the question is CUC as the anti codon which means…
Q: An outbreak of Ebola between 2014 and 2016 resulted in 28,616 cases and 11,310 deaths in Guinea,…
A: Ebola virus disease (EVD), known as Ebola haemorrhagic fever, is a rare disease, but of the severe…
Q: Xeroderma pigmentosum is an inherited disorder characterized by rapid formation of many skin sores…
A: Xeroderma pigmentosum is a disease caused due to mutation in autosomal genes and being a genetic…
Q: Which are the two generalizations can be illustrated by CCK?
A: The digestive system in the human body is the one that consists of different organs which work…
Q: Explain why the gene for sickle cell anemia may be beneficial to humans at some point. Describe…
A: Sickle cell anemia is an autosomal disease in which the red blood cells become sickle-shaped. In…
Q: Identify the polypeptide that is found with a-globin in human fetal hemoglobin (first appearing in…
A: Fetal hemoglobin helps in carrying of oxygen in fetus. It is synthesized at about six weeks of…
Q: In references to the "alpha-globin gene locus" or "beta-globin gene locus", the term "locus" means
A: Chromosomes are condensed form of chromatin. Chromosomes consist of two chromatids which are held…
Q: Which of the following can you conclude about the hemoglobin in individuals with sickle cell anemia?…
A: The sickle cell anaemia is found because of sickle shaped red blood cells in place of normal concave…
Q: Tay–Sachs disease is a severe autosomal recessive genetic disease that produces deafness, blindness,…
A: Tay-Sachs disease is a neurodegenerative disease that is caused by the mutation of the gene HEXA…
Q: The H gene encodes an enzyme that modifies the base carbohydrate to which the A and B antigens…
A: The antigens are present on the red blood cells. The presence of antigen on the red blood cell…
Q: ckle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal…
A:
Q: Are there any globin pseudogenes in mammals? Explain.
A: Normal genes are made of the sequences of DNA that code for genes, responsible for the synthesis of…
Q: Q. "Pericarditis-myocarditis syndrome" is caused by which of the following cytotoxic agent?? A.…
A: Pericarditis- myocarditis syndrome:- Pericarditis is the inflammation of the outer fibro-serous…
Q: Approximately 1 in 100 West Africans suffer from sickle-cell anemia. Given the often devastating…
A: A genetic disorder is a disease, which is caused by abnormalities in a person’s Deoxyribonucleic…
Q: Imagine that a mutation in the gene encoding the cholera toxin was made. This mutation affects the…
A: Intestinal epithelial cells line the outer layer of gastrointestinal epithelium, they are…
Q: Describe what are missense mutations and its effects on structure and function using haemoglobin as…
A: A missense mutation may be a mistake within the DNA which ends up within the wrong aminoalkanoic…
Q: What other possible organizations of the globin gene could exist if there were no need for a globin…
A: Chaperones are necessary for the formation of different structures or organizations of the genes as…
Q: is sickle-cell anemia life-threatening? if Sickle-cell anemia is a genetic disorder of homozygous…
A: Red blood cells in sickle-cell anaemia, an autosomal recessive condition, take on this morphology.…
Q: he following statements is FALSE [ Select] [Select ] Sickle-cell anemia results in lower oxygen…
A: Sickle Cell anaemia is an autosomal recessive disease in which the hemoglobin is affected and…
Q: Which protein in the human erythrocyte is properly categorized as a transmembrane protein?…
A:
Q: here is a benign congenital condition called Hereditary Persistence of Fetal Hemoglobin (HPFH) in…
A: Hereditary Persistence of Fetal Hemoglobin is the condition when there is still fetal hemoglobin…
Q: N-glycosyltransferase attaches which sugar to the base oligosaccharide to synthesize the B antigen?…
A: The antigens A, A1, B, and AB, which are expressed differently on the surface of RBCs, other cells,…
Q: a. What are the major symptoms of sickle-cell anemia? b. Describe two other features of this…
A: What are the major symptoms of sickle-cell anemia? Virtually all of the most important symptoms of…
Q: Which protein is responsible for the ability of influenza virus to bind to epithelial cells?…
A: Influenza is commonly known as the flu. It is commonly caused by the influenza virus. The symptoms…
Q: 46. Identify the polypeptide that is found with a-globin in human fetal hemoglobin (first appearing…
A: Fetal hemoglobin is the oxygen carrier protein found in human fetus. Fetal hemoglobin is present in…
Q: For the following diseases, describe the best technique for diagnosing them. Please make sure you…
A: Factor V Leiden is a mutated form of blood clotting factor V. Blood clotting factors are proteins…
Q: Match the following protein pair with whther they are orthologues, paralogues or neither.…
A: Homologous genes are those gene that share a common evolutionary ancestor. A pair of homologous…
Q: Consider the genes that specify the structure of hemoglobin. Arrange the following events in the…
A: Hemoglobin is present in red blood cells.Hemoglobin is made up of heme and oxygen molecule and…
Q: Match each nucleobase to its corresponding pair. 1. pairs with cytosine 2. pairs with guanine 3.…
A: Given: Nucleic acids are the polymers of nucleotides.Nucleic acids are the macromolecules found in…
Q: What is the reason why "AUTOcoids" changed to AUTACOIDS? Are there implication of the change
A: Autacoids or "autocoids" are biological factors which act like local hormones, have a brief…
Q: Polymorphism implies that each different MHCprotein binds a different peptide motif. For the…
A: Major Histocompatibility complex is a peptide found over the surface of leukocyte (WBC) cells which…
Q: The mutation causing sickle-cell anemia in humans, which changes the normal T to an A in the sixth…
A: Hemoglobin is a normal globin protein with heme (iron) in the red blood cells. It helps to…
Q: Sickle-cell anemia is a genetic disorder of individuals homozygous for a mutation of hemoglobin that…
A: Sickle cell anemia is an autosomal disease in which the red blood cells become sickle-shaped. In…
Q: One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood…
A: When a DNA sequence changes, it can be referred to as mutation. Effect of mutagens, exposure to…
Q: Properdin A. Splits Factor D into Da and Db B. Splits Factor B into Ba and Bb C. Splits…
A: Our body has both direct and alternate pathways to kill the pathogens. Epidermis, mucous cells…
Q: Identify the human form of hemoglobin that is produced only by the embryo. two a-globin chains…
A: Hemoglobin is a metalloprotein present in the red blood cells which is responsible for carrying…
Q: Why are proteins synthesised from spirulina called single cell anemia?
A: Single-cell proteins are the proteins that are edible and are derived from single-celled organisms.…
Q: 4. Figure shows a part of the sequence alignment of human and whale myoglobin proteins. Please…
A: Ans: Mutation: The change in the single nucleotide or multiple nucleotide which may results in loss…
Q: Why do you suppose that the influenza virus protein that binds the virus toan infected cell is…
A: The influenza virus protein that binds the virus to diseased or infected cell is called…
Q: Sickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal…
A: q2 is the frequency of ressesive allele(ss) q2 = 11% = 0.11 q = 0.3317 p = 1 - q = 1 - 0.3317 p =…
Q: Parents who both have "sickle-cell trait", i.e, are heterozygous for HbS have a child who is tested…
A: Sickle cell anemia is a blood disorder in which a mutation in one the hemoglobin genes causes the…
Q: Why is sickle-cell anemia life-threatening
A: Introduction Genetic disorders are those that are inherited from the parents to the next generation.…
Q: Sickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal…
A: Sickle-cell anemia is a genetic disease. Homozygous individuals (SS) have normal blood cells that…
Q: Xeroderma pimentos is an inherited disorder characterized by rapid formation of many skin sores that…
A: Xeroderma pimentos: It is an inherited disorder which is caused by UV light that will decrease the…
Q: Why do you suppose that the influenza virus protein that binds the virus to an infected cell is…
A: Hemagglutinin are glycoproteins which cause red blood cells to agglutinate or clump together.
-
Sickle cell disease results from a point mutation of the ______.
-
α-globin of guanine for glutamine
-
β-globin of valine for glutamate
-
β-globin of histidine for glycine
-
γ-globin of proline for tyrosine
-
γ-globin of glutamate for guanine
-
Step by step
Solved in 2 steps
- Sickle-cell anemia is a genetic disorder of individuals homozygous for a mutation of hemoglobin that causes their red blood cells to be sickle shaped and stiff under conditions of low pO2. Why is this disease life threatening?Sickle-cell disease (often called sickle-cell anemia) is a disease that is caused by a mutation to the gene that is responsible for producing the protein hemoglobin. Remember that hemoglobin is a protein in the red blood cells which is responsible for carrying oxygen throughout the body. When a person possesses the mutated hemoglobin allele, their red blood cells take on an altered shape and this results in a variety of symptoms ranging from general weakening of the body, damage to the organs and even death. The sickle cell allele is recessive to the healthy allele, thus only individuals that are homozygous for the recessive allele will have sickle-cell disease. Individuals that are homozygous for the healthy allele, along with heterozygous, individuals will be physically healthy. Question: Given that this mutated allele will cause disease and death in individuals, what would you predict to occur to the frequency of this allele in the population? Explain.Why does vaccination provide long-lasting protection against a disease, while gamma globulin (IgG) provides only short-term protection? Many parents are electing to not vaccinate their children.
- The study of the b-globin gene helped establish the one gene-one polypeptide relationship. Which of the following statements related to the b-globin gene study is true? a. all mutations in the b-globin gene lead to sickle cell disease b. some mutations in the b-globin gene lead to sickle cell disease c. all mutations in the b-globin gene altered the b chain in hemoglobinA researcher was studying red blood cells from a patient homozygous for the sickle cell mutation in the B-globlin gene (BE6V). She found that increasing the concentration of one of the following chemicals decreased the frequency of sickling by these cells. What chemical is this most likely to be and why? A. 2,3 BPG B. Fe2+ C. glucose D. histidine E. O2Define a Point mutation and give an example. What is sickle cell anemia and what causes it. What is nondisjunction? How does nondisjunction cause disorders? NUMER YOUR ANSWERS
- Fill in the blank: Polymorphonuclear leukocyte is another name for a _______________________ with a segmented nucleus.Sickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of this genetic defect causes deformation of red blood cells. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to survive better than either of the homozygous conditions. Assuming HWE, if 9% of an African population is born with a severe form of sickle-cell anemia (ss), what percentage of the population will be more resistant to malaria…A certain molecule will not dissolve in water and has a structure consisting of glycerol covalently bound to three fatty acid tails. What is the function of this molecule? A:Genetic information storage B:Cell communication C:Catalysis of chemical reactions D:Energy storage
- The production of arginine is terminated by the presence of excess arginine. State which phenomenon is responsible for this outcome. Explain the phenomenon in brief.Which of the given disorder can be seen in an individual when the mutation includes substitution of a purine by pyrimidine? 1. Chronic myelogenous leukemia 2. Sickle cell anaemia 3. a thalassemia 4. B thalassemiaWhat would happen if a mutation in DNA changed codon 6 in the mRNA to GUA? ( one nucleotide substitution creates sickle-cell anemia)This