Steps 1 & l': Transimination: Enzyme Enzyme H Enzyme R-C-CO0 H-N (CH2)4 (CH)4 (CH)4 H H-C H H- NH H-C R- -COO + NH, 2-0, PO 20,PO CH3 CH3 CH H Amino acid-PLP Sehiff base (aldimine) a-Amino acid Enzyme-PLP Schiff base Geminal diamine intermediate Steps 2 & 2': Tautomerization: Lyn-Enzyme Lys - Enzyme Lys-Enzyme COH H,N: R- C00 H,NH R-Ça C00 H,NH R-Ça-CO0 H-C H-C 10,PO CH3 CH, CH Ketimine Resonance-stabilized intermediate Steps 3 & 3': Hydrolysis: Lyn-Enzyme Lys - Enzyme H. H,N: H,N: R-C-CO0 H-C-H NH H-C-H 2-0, PO R--CO0 a-Keto acid 20, PO CH CH Pyridoxamine phosphate (PMP)- Carbinolamine enzyme
Steps 1 & l': Transimination: Enzyme Enzyme H Enzyme R-C-CO0 H-N (CH2)4 (CH)4 (CH)4 H H-C H H- NH H-C R- -COO + NH, 2-0, PO 20,PO CH3 CH3 CH H Amino acid-PLP Sehiff base (aldimine) a-Amino acid Enzyme-PLP Schiff base Geminal diamine intermediate Steps 2 & 2': Tautomerization: Lyn-Enzyme Lys - Enzyme Lys-Enzyme COH H,N: R- C00 H,NH R-Ça C00 H,NH R-Ça-CO0 H-C H-C 10,PO CH3 CH, CH Ketimine Resonance-stabilized intermediate Steps 3 & 3': Hydrolysis: Lyn-Enzyme Lys - Enzyme H. H,N: H,N: R-C-CO0 H-C-H NH H-C-H 2-0, PO R--CO0 a-Keto acid 20, PO CH CH Pyridoxamine phosphate (PMP)- Carbinolamine enzyme
Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter16: Gene Expression
Section: Chapter Questions
Problem 3VCQ: Figure 16.13 An increase in phosphorylation levels of elF-2 has been observed in patients with...
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PLP is a cofactor for a number of enzymes involved in amino acid
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