It is known that the amino acid at position 523 of the cyclooxygenase enzyme is part of the active site. In the isoenzyme COX-1, this amino acid is isoleucine, whereas in COX-2, it is valine. Suggest how such information could be used in the design of drugs that selectively inhibit COX-2. It is known that the amino acid at position 523 of the cyclooxygenase enzymeis part of the active site. In the isoenzyme COX-1, this amino acid is isoleucine,whereas in COX-2, it is valine. Suggest how such information could be used inthe design of drugs that selectively inhibit COX-2.

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General, Organic, and Biological Chemistry

7th Edition

ISBN:9781285853918

Author:H. Stephen Stoker

Publisher:H. Stephen Stoker

Chapter21: Enzymes And Vitamins

Section: Chapter Questions

Problem 21.44EP: Based on the graphical information in Problem 21-41 about enzymes A and B indicate whether the...

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It is known that the amino acid at position 523 of the cyclooxygenase enzyme is part of the active site. In the isoenzyme COX-1, this amino acid is isoleucine, whereas in COX-2, it is valine. Suggest how such information could be used in the design of drugs that selectively inhibit COX-2.

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