Table 1. The most common endogenous opioid peptides produced in humans Рeptide Enkephalins Leu-enkephalin YGGFL Met-enkephalin YGGFM Metorphamide YGGFMRRV-NH2 Peptide E Peptide Sequence YGGFMRRVGRPEWWMDYQKRYGGFL Endorphins B-endorphin Y-endorphin a-endorphin YGGFMTSEKSQTPLVTLF KNAIIKNAYKKGE YGGFMTSEKSQTPLVTL YGGFMTSEKSQTPLVT Dynorphins Dynorphin A Dynorphin B Dynorphin1-8 YGGFLRRQ a-neoendorphin YGGFLRKYPK B-neoendorphin YGGFLRKYP YGGFLRRIRPKLKWDNQ YGGFLRRQFKWT 1. Endogenous opioids are peptides that are naturally produced in our bodies at low amounts and at specific times (see Table 1). These peptides bind to specific protein receptors in our nervous system that mediate pain signaling and reward. The chemical structure of an endogenous opioid peptide is shown below. но CHз S нн N. H2N HO н нн 1 2 3 4 5 6 d) How many peptide bonds are in the structure (encircle one)? e) Identify all the peptide bonds by crossing out (place an X) at each peptide bond. f) How many ionizable functional groups are in the peptide (encircle one)? 1 2 3 4 5 6 g) Which amino acid in this peptide has a side chain that can form hydrogen bonds with water? Is this side-chain an H-bond donor, acceptor, or both? I ZI IZ о ZI I

Table 1. The most common endogenous opioid peptides produced in humans Рeptide Enkephalins Leu-enkephalin YGGFL Met-enkephalin YGGFM Metorphamide YGGFMRRV-NH2 Peptide E Peptide Sequence YGGFMRRVGRPEWWMDYQKRYGGFL Endorphins B-endorphin Y-endorphin a-endorphin YGGFMTSEKSQTPLVTLF KNAIIKNAYKKGE YGGFMTSEKSQTPLVTL YGGFMTSEKSQTPLVT Dynorphins Dynorphin A Dynorphin B Dynorphin1-8 YGGFLRRQ a-neoendorphin YGGFLRKYPK B-neoendorphin YGGFLRKYP YGGFLRRIRPKLKWDNQ YGGFLRRQFKWT 1. Endogenous opioids are peptides that are naturally produced in our bodies at low amounts and at specific times (see Table 1). These peptides bind to specific protein receptors in our nervous system that mediate pain signaling and reward. The chemical structure of an endogenous opioid peptide is shown below. но CHз S нн N. H2N HO н нн 1 2 3 4 5 6 d) How many peptide bonds are in the structure (encircle one)? e) Identify all the peptide bonds by crossing out (place an X) at each peptide bond. f) How many ionizable functional groups are in the peptide (encircle one)? 1 2 3 4 5 6 g) Which amino acid in this peptide has a side chain that can form hydrogen bonds with water? Is this side-chain an H-bond donor, acceptor, or both? I ZI IZ о ZI I

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter4: Principles Of Neural And Hormonal Communication

Section: Chapter Questions

Problem 18RE

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