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The chemical structure of an endogenous opioid peptide is shown belowHOCH3SH HHHH2NHOH HZIIIZZIIZI TABLE 3.1 Typical pKa values of ionizable groups in proteinsGroupBaseTypical pk,AcidTerminal a-carboxylgroup3.1Aspartic acidGlutamic acid4.1HнHistidine6.0HH-NH-NHTerminal a-amino group8.0нHSCysteine8.3H-NH-NTHнLysine10.8НHоТугosine10.9нN-HHJНArginine12.5N-HнN-HHTymoczko et al., Biochemistry: A Short Course, 4e,O 2019 W. H. Freeman and Company

Question

Calculate the isoelectric point (pI) of the peptide structure shown. Use table 3.1 for pKa values.

The chemical structure of an endogenous opioid peptide is shown below
HO
CH3
S
H H
H
H
H2N
HO
H H
ZI
I
IZ
ZI
IZ
I
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The chemical structure of an endogenous opioid peptide is shown below HO CH3 S H H H H H2N HO H H ZI I IZ ZI IZ I

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TABLE 3.1 Typical pKa values of ionizable groups in proteins
Group
Base
Typical pk,
Acid
Terminal a-carboxyl
group
3.1
Aspartic acid
Glutamic acid
4.1
H
н
Histidine
6.0
H
H
-N
H
-N
H
Terminal a-amino group
8.0
н
H
S
Cysteine
8.3
H
-N
H
-N
TH
н
Lysine
10.8
Н
H
о
Тугosine
10.9
н
N-H
HJ
Н
Arginine
12.5
N-H
н
N-H
H
Tymoczko et al., Biochemistry: A Short Course, 4e,O 2019 W. H. Freeman and Company
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TABLE 3.1 Typical pKa values of ionizable groups in proteins Group Base Typical pk, Acid Terminal a-carboxyl group 3.1 Aspartic acid Glutamic acid 4.1 H н Histidine 6.0 H H -N H -N H Terminal a-amino group 8.0 н H S Cysteine 8.3 H -N H -N TH н Lysine 10.8 Н H о Тугosine 10.9 н N-H HJ Н Arginine 12.5 N-H н N-H H Tymoczko et al., Biochemistry: A Short Course, 4e,O 2019 W. H. Freeman and Company

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