The goal of most gene therapies is to insert a healthy copy of a gene into the genome.  Besides CRISPR, techniques for integrating DNA into the genome do not target that DNA to a particular genomic location and thus different cells end up with the DNA sequence in different positions. A.    It has been shown that where the healthy gene integrates is heavily influenced by chromatin.  Why?

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Asked Dec 1, 2019
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The goal of most gene therapies is to insert a healthy copy of a gene into the genome.  Besides CRISPR, techniques for integrating DNA into the genome do not target that DNA to a particular genomic location and thus different cells end up with the DNA sequence in different positions.

 A.    It has been shown that where the healthy gene integrates is heavily influenced by chromatin.  Why?

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Expert Answer

Step 1

Genome editing:

It is also known as gene editing or genome engineering. It is a type of genetic engineering. In this editing, the DNA is commonly inserted, deleted, altered or replaced in a living organism genome.

Various gene editing techniques (such as transcription activator-like effector nucleases, CRISPR-Cas systems, TALENs and zinc-finger nucleases have been developed to get a progress in the gene targeting methods.

Step 2

CRISPR-Cas or CRISPR-associated protein systems:

It is a type of genome editing tool. It is cheaper, faster and more precise than the preceding techniques of the editing DNA. It has a broad array of the potential applications.

The main advantage of CRISPR/Cas in the genome editing technologies is because of its simplicity and efficiency. It is the most versatile and specific method of the genetic manipulation. As, the CRISPR/Cas can be used directly in the embryo.

Step 3

Chromatin remodeling:

It is the chromatin rearrangement from a condensed condition to a transcriptionally accessible condition. It allows the t...

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