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The inhibitory effect of an uncompetitive inhibitor is greater at high [S] than
at low [S]. Explain this observation.
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- What is the minimum inhibitory concentration indicated in the following image?Using equilibrium argument, why does Km apparently increase, decrease or stay the same in uncompetitive inhibition?If the higher value of KM resulting in the new plot ( red curb ) is due to the presence of an enzyme inhibitor is inhibitor reversible or irreversible? And why?
- When we compare the binding of I and of S to the enzyme in a mixed noncompetitive inhibitor, we assumed that the binding of I decreased the affinity of the enzyme for S. What would happen if the opposite were true?why is non-competitive inhibiton a special type of mixed inhibiton?Is the inhibitor competitive or uncompetitive or non-competitive and why?
- The nerve gas sarin acts as a poison by covalently bonding to a hydroxyl group in the active site of the enzyme acetylcholinesterase. This binding results in a higher-than-normal amount of acetylcholine at a nerve synapse, resulting in muscle spasms. From this description, would you expect sarin to be a competitive, noncompetitive, or irreversible inhibitor? noncompetitive inhibitor irreversible inhibitor competitive inhibitorGive an example of a noncompetitive inhibitor and its target enzyme. Draw a hypothetical Michaelis-Menten curves in the presence and absence of the noncompetitive inhibitor. Discuss the effects of noncompetitive inhibition and the reasons for these effects on the values of Km and Vmax.If the new higher KM value is 0.1 mM resulting in the new plot red curve is due to presence of enzyme inhibitor is the inhibitor reversible or irreversible?
- Write a balanced equation for the hydrolysis of cGMP, catalyzed by cGMP phosphodiesterase. Would you expect an inhibitor of this enzyme to potentiate or antagonize the action of Viagra? Explain.Chymotrypsin preferentially binds the transition state. What is meant by that?What are the two types of enzyme inhibitors? Give anexample of each.