The last part of the synthesis is to assemble moieties 8 and 11a together. N. НО HN P-O HCI (aq) 12 11 a "CN "CN HƠ он 1 8 5a. During the formation of compound 12, an inversion of stereochemistry has occurred. Note that 11a is a single stereoisomer of 11.

Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter19: Eas: Electrophilic Aromatic Substitution
Section: Chapter Questions
Problem 17E
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The last part of the synthesis is to assemble moieties 8 and 11a together.
N.
НО
N'
N.
N.
HNP-O
HCI (aq)
12
11 a
'CN
"CN
HỢ
1
8
5a. During the formation of compound 12, an inversion of stereochemistry has
occurred. Note that 11a is a single stereoisomer of 11.
Draw structures of 11a and 12.
5b. What is the leaving group during the formation of 12? Draw resonance
structures of this leaving group to show why it is a good leaving group.
Transcribed Image Text:The last part of the synthesis is to assemble moieties 8 and 11a together. N. НО N' N. N. HNP-O HCI (aq) 12 11 a 'CN "CN HỢ 1 8 5a. During the formation of compound 12, an inversion of stereochemistry has occurred. Note that 11a is a single stereoisomer of 11. Draw structures of 11a and 12. 5b. What is the leaving group during the formation of 12? Draw resonance structures of this leaving group to show why it is a good leaving group.
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