The mouse and human genome have large syntenic blocks of genes in common Mouse chromosome 11 60 65 70 75 80 85 90 95 100 105 110 115 120 Ancestral chromosome o 15 20 25 55 60 10 30 35 40 45 50 65 70 Human chromosome 17 O 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 FIGURE 14-17 Synteny between human chromosome 17 and mouse chromosome 11. Large conserved syntenic blocks 100 kb or greater in size are shown in human chromosome 17, mouse chromosome 11, and the inferred chromosome of their last common ancestor (reconstructed by analysis of other mammalian genomes). Direct blocks of synteny are shown in light purple; inverted blocks are shown in green. Chromosome sizes are indicated in megabases (Mb). [Data from M. C. Zody et l., "DNA Sequence of Human Chromosome 17 and Analysis of Rearrangement in the Human Lineage," Nature 440, 2006, 1045–1049, Fig. 2.]

The mouse and human genome have large syntenic blocks of genes in common Mouse chromosome 11 60 65 70 75 80 85 90 95 100 105 110 115 120 Ancestral chromosome o 15 20 25 55 60 10 30 35 40 45 50 65 70 Human chromosome 17 O 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 FIGURE 14-17 Synteny between human chromosome 17 and mouse chromosome 11. Large conserved syntenic blocks 100 kb or greater in size are shown in human chromosome 17, mouse chromosome 11, and the inferred chromosome of their last common ancestor (reconstructed by analysis of other mammalian genomes). Direct blocks of synteny are shown in light purple; inverted blocks are shown in green. Chromosome sizes are indicated in megabases (Mb). [Data from M. C. Zody et l., "DNA Sequence of Human Chromosome 17 and Analysis of Rearrangement in the Human Lineage," Nature 440, 2006, 1045–1049, Fig. 2.]

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter6: Cytogenetics: Karyotypes And Chromosome Aberrations

Section: Chapter Questions

Problem 1QP: Analyzing Karyotypes 1. Originally, karyotypic analysis relied only on size and centromere placement...

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A normal chromosome A B C D * E F G H I J K has mutated toA B C F E * D G H I J K J K.This is an example of a _________________ chromosomal mutation. ( * denotes the centromere) Group of answer choices Pericentric inversion of DEF and tandem duplication of JK. Pericentric inversion of DEF and displaced duplication of JK Paracentic inversion of DEF and displaced duplication of JK. Paracentric inversion of DEF and tandem duplication of JK.
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