The NF-κB signaling pathway, an important pathway in immune response and inflammation, is shown in the image. One of the pathway steps is the phosphorylation of IκBα. Which of the following best describes the role IκBα phosphorylation plays in the signaling pathway and what the modification of IκBα does? IκBα activates the transcription factor. Phosphorylation of IκBα leads to phosphorylation and activation of the transcription factor. IκBα inhibits the activation of the transcription factor. Phosphorylation of IκBα signals for the nuclear transcription factor to transcribe DNA. IκBα inhibits the translocation of the transcription factor. Phosphorylation of IκBα signals for IκBα degradation and allows the transcription factor to enter the nucleus. IκBα activates the translocation of the transcription factor. Phosphorylation of IκBα leads to phosphorylation of the transcription factor, which allows the transcription factor to enter the nucleus.
The NF-κB signaling pathway, an important pathway in immune response and inflammation, is shown in the image. One of the pathway steps is the phosphorylation of IκBα. Which of the following best describes the role IκBα phosphorylation plays in the signaling pathway and what the modification of IκBα does? IκBα activates the transcription factor. Phosphorylation of IκBα leads to phosphorylation and activation of the transcription factor. IκBα inhibits the activation of the transcription factor. Phosphorylation of IκBα signals for the nuclear transcription factor to transcribe DNA. IκBα inhibits the translocation of the transcription factor. Phosphorylation of IκBα signals for IκBα degradation and allows the transcription factor to enter the nucleus. IκBα activates the translocation of the transcription factor. Phosphorylation of IκBα leads to phosphorylation of the transcription factor, which allows the transcription factor to enter the nucleus.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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The NF-κB signaling pathway, an important pathway in immune response and inflammation, is shown in the image. One of the pathway steps is the phosphorylation of IκBα.
Which of the following best describes the role IκBα phosphorylation plays in the signaling pathway and what the modification of IκBα does?
IκBα activates the transcription factor. Phosphorylation of IκBα leads to phosphorylation and activation of the transcription factor.
IκBα inhibits the activation of the transcription factor. Phosphorylation of IκBα signals for the nuclear transcription factor to transcribe DNA.
IκBα inhibits the translocation of the transcription factor. Phosphorylation of IκBα signals for IκBα degradation and allows the transcription factor to enter the nucleus.
IκBα activates the translocation of the transcription factor. Phosphorylation of IκBα leads to phosphorylation of the transcription factor, which allows the transcription factor to enter the nucleus.
Transcribed Image Text:Signals Receptor
Proteasome
Receptor
degradation
Changed
cell
IkBa
function Protein
IxBa
IKK
ReIA
Nuclear
MRNA
RelA, p50 pore
p50
Ribosome
RelA p50
Coactivator
Cytoplasm
Nuclear
envelope
RNA polymerase
MRNA
Nuclear
DNA
www
RE Target gene
Cell
membrane
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