The recruitment of Histone deacetylase (HDACS).... O a. Enzymatically adds acetyl groups to E2f target genes. b. O D. Forms a complex with E2f to activate transcription. OC. Remodels chromatin into a repressed state. O d. Forms a complex with hyperphosphorylated pRb.
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- Regulation of Gene Expression by Chromatin Modification is Local and Dynamic! What does the statement above mean?Which of these is NOT true of nucleosomes? A. Some post-translational modifications to histone proteins serve as binding sites for transcription factors. B. The position of nucleosomes is fixed on the genome and can not be changed. C. The position and post-translational modifications of histones can be inherited through mitosis. D. The binding between DNA and histone proteins can be disrupted by post-translational modifications.Which is the expected outcome following the deacetylation of histones? a) Coiling of chromatin, preventing it from being accessed by transcriptional machinery b) Coiling of chromatin, allowing it to be accessed by transcriptional machinery c) Uncoiling of chromatin, preventing it from being accessed by transcriptional machinery d) Uncoiling of chromatin, allowing it to be accessed by transcriptional machinery
- According to the histone-code hypothesis, what is one way that cell specialization occurs? a) Differential DNA methylation patterns b) Variation in enhancers in different cells c) TFII transcription factors binding to different histones in a cell-specific manner d) Differential expression of histone modifying enzymes e) Different histones are expressed in different cellsChanges in chromatin packing correlate with changes in gene expression in most cells. Why do you think this is the case?Several new cancer drugs inhibit the enzymes that either put acetyl groups on histones or take them off. Suppose you are a researcher combating a cancer caused by too much expression of a gene that normally codes for a proto-oncogene gene Would you develop a drug that adds or removes acetyl groups? please indicate which one you would choose and why
- What is a possible outcome of the addition of a transcription factor such as Myod to the nucleus of a cell? Assume that there are no other factors to either activate or prevent the response of the cell. Group of answer choices A) Production of mRNA from genes that were previously not expresed B)adding methyl groups to DNA C)prevention of protein synthesis D)uncoiling of the chromatin to allow transcription_____ is the combination of a seat, elation, another modifications to the histones that allow for changes in DNA winding and unwinding a. Epigentics b. Histone code c. Heterochromatin d. Post translational modificationsThe interphase is the part of the eukaryotic cell cycle that is most transcriptionally active. Gene regulation during this phase involves changes in the chromatin. a) What is chromatin? b) How can the chromatin structure change?
- Histones can be modified to turn genes on and off. Which type of chromatin is associated with transcriptionally active regions of the DNA?Can one transcription factor sometimes act as a repressor and sometimes act as an activator? a. Yes, but it depends on where the transcription factor binds in the promoter b. Yes, but it depends on other proteins that might act with the transcription factor c. No, transcription factors are always either activators or repressors d. Yes, but only if a mutation happensAccording to the histone code hypothesis, the pattern of histone modifications acts like a language that a. influences chromatin structure. b. promotes transcriptional termination. c. inhibits the elongation of RNA polymerase. d. does all of the above.