protein. Hypothesize what type of amino acid R groups you might find on the ii)exterior regions of each of these proteins, iii) and on the membrane bound portionof these proteins.b) The tertiary structure of gp120 is shown below. Please describe the protein (makesure to cover primary, secondary, and tertiary levels).CDR H31FD6 scaffoldAsn 160 glycanCDR L3CDR L1CDR L2PG9 light chainCAP45 V1/V2V2 loopV1 loopAsn 156 glycanCDR H2CDR H1PG9 heavy chain 1. Glycoproteins coat the outside of viruses; in particular they are important inhelping HIV dock to our cells and also help the virus evade our immune system.Below is an image of the HIV transmembrane gp120 protein docking to human cd4cells via the CXCR4 receptor.HIV-gp120HIVCXCR4CoreceptorCCR5CoreceptorCD4ReceptorCD4 Cella) i) Describe the general chemical interactions that might be involved in protein-protein interactions between the HIV gp120 protein and the human cd4 CXCR4protein. Hypothesize what type of amino acid R groups you might find on the ii)exterior regions of each of these proteins, iii) and on the membrane bound portionof these proteins.b) The tertiary structure of gp120 is shown below. Please describe the protein (makesure to cover primary, secondary, and tertiary levels).

The primary structure of gp120 is the sequence of amino acids that make up the protein. This…

Answered: The tertiary structure of gp120 is…

The tertiary structure of gp120 is shown below. Please describe the protein (make sure to cover primary, secondary, and tertiary levels).

Biology: The Unity and Diversity of Life (MindTap Course List)

14th Edition

ISBN:9781305073951

Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Chapter20: Viruses, Bacteria, And Archaea

Section: Chapter Questions

Problem 3DAA

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Concept explainers

Nucleotides

It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).

Nucleic Acids

Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.

Question

protein. Hypothesize what type of amino acid R groups you might find on the ii)
exterior regions of each of these proteins, iii) and on the membrane bound portion
of these proteins.
b) The tertiary structure of gp120 is shown below. Please describe the protein (make
sure to cover primary, secondary, and tertiary levels).
CDR H3
1FD6 scaffold
Asn 160 glycan
CDR L3
CDR L1
CDR L2
PG9 light chain
CAP45 V1/V2
V2 loop
V1 loop
Asn 156 glycan
CDR H2
CDR H1
PG9 heavy chain

1. Glycoproteins coat the outside of viruses; in particular they are important in
helping HIV dock to our cells and also help the virus evade our immune system.
Below is an image of the HIV transmembrane gp120 protein docking to human cd4
cells via the CXCR4 receptor.
HIV-gp120
HIV
CXCR4
Coreceptor
CCR5
Coreceptor
CD4
Receptor
CD4 Cell
a) i) Describe the general chemical interactions that might be involved in protein-
protein interactions between the HIV gp120 protein and the human cd4 CXCR4
protein. Hypothesize what type of amino acid R groups you might find on the ii)
exterior regions of each of these proteins, iii) and on the membrane bound portion
of these proteins.
b) The tertiary structure of gp120 is shown below. Please describe the protein (make
sure to cover primary, secondary, and tertiary levels).

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