This molecule forms a dimer via pi interactions, resulting to effective molecular stacking. If the molecule can inhibit toxic effects at 0.5mM against gastric carcinoma cells, does it mean that the dimer of this nucleoside analogue will exhibit an IC50 of about 0.25mM?

Q: Based on the figure and the explanation in the textbook, what are the random chances that the…

A: Denaturation is the process by which proteins lose their native conformation. Ribonuclease A has 124…

Q: what would the net charge on the tetra peptide of sequence ala-lys-glu-ser at ph 7.2 what would it…

A: Amino acids are the building blocks of proteins or peptides formed of chiral carbon having four…

Q: Choose ALL of the charged (+1 or -1) amino acids at aqueous physiological conditions where the ph=…

A: Amino acid is the basic structural unit of proteins. They contain an amino group, a carboxyl group,…

Q: Briefly describe what additional steps you might employ to purify the ammonium sulphate-precipitated…

A: The purification of phycocyanin can be obtained by various methods. Multiple processes are developed…

Q: Why proline encounters at the myoglobin and hemoglobin molecules where polypeptide chains turns a…

A: The organic acid in which the amino group is not present is called proline. The proline is used for…

Q: Briefly describe each of the following possible posttranslational protein modifications.  Give an…

A: The deoxyribonucleic acid (DNA) is the genetic material of the organism that is transcripted to form…

Q: . Disulfide bonds have been shown to stabilize proteins (i.e., make them less likely to unfold).…

A: In disulfide linkage, the two cysteine amino acids are joined by a disulfide bond.

Q: Given a tripeptide Cys-His-Lys, Cys: Pk1 = 1.71; Pk2 = 10.78; PkR = 8.33 His: Pk1 = 1.82; Pk2 =…

A: pK refers to pH at which a particular group is exactly 50% ionized. A tripeptide is a peptide…

Q: In TLC, why are the colors of the peaks for each amino acid are different depending on the types of…

A: TLC stands for Thin Layer Chromatography. It is a refined technique that is used for isolating or…

Q: Saccharide M, a sugar made of repeating units of maltose and cellobiose, is a component of…

A: Glycoproteins are consisted of protein and glycan moiety which is involved in several biological…

Q: The effect of base-pair substitution mutations on protein function varies widely from no detectable…

A: A mutation is any alteration in the nucleotide sequence that changes the sequence of DNA, RNA and…

Q: For the following sequence, what is the approximate annealing temperature? 5'-AGCTACGATCAGGTCA-3'

A: PCR (Polymerase Chain Reaction) is divided into three main steps : Denaturation of DNA, Annealing of…

Q: Metalloprotein linkages are most likely to be formed between: a.Two cysteines b.An arginine and a…

A: Metalloprotein linkages are most likely to be formed between?

Q: For the trinucleotide 5’ G-C-A-3’ How many nucleotide subunits are present in its ‘backbone’?…

A: The nucleic acid is the type of macromolecules found in all living organisms. The DNA is made of…

Q: What is a cavity mutant? Which sites in the L121A/L133A mutants demonstrated higher mobility of the…

A: Mutants are organisms that have a change in the nucleotide sequence due to some abrupt changes or…

Q: Hemoglobin is a complex protein that contains four polypeptide chains. The normal hemoglobin found…

A: On the basis of the given information, it can easily be concluded that the medical condition of…

Q: A protein sample of unknown concentration was placed in a cuvette with a path length of 1 cm and the…

A: The concentration of a protein is directly proportional to the amount of light it absorbs. The…

Q: A heptapeptide when treated with trypsin produced two peptides. T1 (D, G, Y) and T2 (K, F, V, A).…

A: Peptide includes a short chain of amino acids that are connected to each other by peptide bond. A…

Q: SDS-PAGE and Agarose gel electrophoresis can both be used to separate proteins or protein- complexes…

A: Given Values: SDS-PAGE bands = 86 kD and 136 kD Agarose gel band = 222 kD and 444 kD

Q: Under what pH conditions can a protein not bind to the beads in a column?     pH = -pKa     pH =…

A: Amino acids are the building blocks of proteins. All of the proteins found inside the cell are made…

Q: How many hemoglobin molecules are there in an average red cell? Assume that the molecular weight of…

A: Blood is the circulatory fluid of the body. It is a buffer that bears the fluctuations in the pH of…

Q: A normal polypeptide and a mutant of the polypeptide were hydrolyzed by an endopeptidase under the…

A: Chromatography is a useful technique to study the separation of amino acids. Paper chromatography is…

Q: The pK1, pK2, and pKR of the amino acid lysine are 2.2, 9.1, and 10.5, respectively. The pK1, pK2,…

A: Proteins can be successfully separated using many different techniques. Chromatography is the…

Q: When a chromophore binds to proteins, the binding site is generally more hydrophobic than the…

A: Chromophore is a part of a molecule or a chemical group which is responsible for its molecular…

Q: The SARS-CoV-2 spike protein is heavily glycosylated. What are some of the monosaccharides found in…

A: The spike (S) protein of SARS-CoV-2 mediates the virus binding to the human cells via its…

Q: What is meant by denaturation of proteins? Give examples of protein denaturating agent?

A: Proteins are composed of amino acids attached together in a linear chain of via peptide bonds.…

Q: What is the TOTAL NET CHARGE of a free arginine amino acid at pH = 12.5?

A: Arginine is a basic amino acid in which three ionizable groups present. Arginine amino acid consists…

Q: If the molecule can inhibit toxic effects at 0.5mM against gastric carcinoma cells, does it mean…

A: IC 50 is half maximal inhibitory concentration which measures potency of substance to inhibiting…

Q: Shown in the following table are several amino acid substitutionsin the a and b chains of human…

A: Globins are considered an ancient and varied superfamily of proteins. Hemoglobin is an major protein…

Q: please calculate the unknown concentration of the protein A wih an absorbance value of A188 given…

A: Absorbance = -log (I / Io) where I is intensity of transmitted light and Io intensity if incident…

Q: If the molecule can inhibit toxic effects at 0.5mM against gastric carcinoma cells, does it mean…

A: IC50 is the half inhibitory maximum concentration of a drug which inhibits the process 50%.

Q: What is the approximate rate of change of A340 measured? i.e.  ΔA340  / min =  __________ What…

A: Beer-Lambert's law states that the absorption and concentration of a compound are directly…

Q: Describe the secondary and quaternary structure of the red blood cell protein hemoglobin. Which…

A: Hemoglobin has a quaternary construction (structure). It comprises of two sets of various proteins,…

Q: Why is the euchromatic region or light bands in G banding rich in Guanine and cytosine? And why is…

A: euchromatic region or light bands in G banding rich in G C while dark region rich in AT.

Q: Based on the N-terminal amino acid sequence, what is the approximate half-life of the protein after…

A: Introduction- N-terminal methionine cleavage plays an important role in protein synthesis in…

Q: In the deoxy state of HB, which of the following does not occur? O An intra-chain salt bridge…

A: Hemoglobin is an oligomeric conjugated protein with four peptide chains joined by a…

Q: In pyrimidine nucleosides, the anti conformation predominates. Explain. Do the purine nucleosides…

A: Introduction and Explanation: Pyrimidines and purines are the nitrogenous bases that are present in…

Q: Given that a faulty ribosomal protein is the culprit and causes DBA, discuss the possible role of…

A: The bone marrow does not create sufficient red blood cells to carry oxygen across the body in cases…

Q: Given the following information, which protein would be most difficult to isolate from protein X…

A: Salting out is a method of separation of protein mixtures that is based on protein solubility. The…

Q: What is the effect of the altered amino acid sequence in Hb S that causes the cells to form sickle…

A: Introduction: Sickle cell anemia is an inherited disorder in which the shape of red blood cells…

Q: Hydrogen bonds are usually 2.7-3.3 angstrom long. According to this information, do you think there…

A: There is no direct hydrogen bonding between H840 and the phosphodiester bond that links dG13 and…

Q: Describe the chemical difference between mannose and heptyl alpha-D-mannose. Why does FimH have a…

A: Mannose is a type of the monomer of the sugar. Mannose can be produced in the human body and it can…

Q: Imagine that a mutation has been discovered in the HBA1 gene, where amino acid residue # 1 in the…

A: Gel electrophoresis is the technique of separation of molecules on the basis of their size and…

Q: In studies using repeating copolymers, AC . . . incorporates threonine and histidine, and CAACAA . .…

A: A protein's amino acid sequence is determined by the sequence of nucleotides in DNA and RNA.  It is…

Q: Most bacterial mutants that require isoleucine for growth also require valine.Why? Which enzyme or…

A: Mostly the bacteria that require the isoleucine amino acid for growth also requires valine. This is…

Q: Lysozyme consist of 4 disulfide bridges while Bovine Serum Albumin(BSA) is 17. However, lysozyme is…

A: Proteins are the polymers of nitrogenous compounds called amino acids. Each amino acid consists of…

Q: Which of the following mutations would most likely keep the transitions of T state to R state in…

A: Amino acids are organic compounds which contain amino group, carboxyl group and functional groups…