TPI deficiency is a rare human condition. Patients who lack TPI cannot convert the triose dihydroxyacetone phosphate into glyceraldehyde 3-phosphate.What happens to glycolysis in TPI patients?TPI patients suffer from chronic hemolytic anemia (abnormal breakdown of red blood cells) and have variable neuromuscular dysfunctions, including muscle weakness, poor muscle tone, and atrophy. Most die of respiratory failure during childhood. Explain why TPI-deficient patients exhibit these conditions using the diagram to justify your answer. TPI is enzyme 5.G6PD deficiency is one of the most common human genetic conditions, affecting about 40 million people worldwide. Patients suffer from hemolytic anemia when exposed to certain drugs, viral or bacterial disease, or fava beans. HANDOUT AGlucose-6 PhosphateDehydrogenase and TPI DeficienciesOHOH2-O,PO-CH, OHO*OPO—CH,CH,OHOHMutaseOHOH2-0,PO-CH₂ QOH2,3-BisphosphoglyceratePhosphataseOHHỌ2,3-BisphosphoglycerateBisphosphoglycerateНОOHOHCH,OHOHCH₂-OPO,²-OHATP+C-OPO,²-CH₂GlucoseATPHC=OHC-OH Glyceraldehyde-3-PH₂C-OPO,²- PNADNADHH₂O+Glucose-6-PATPFructose-6-P◄1,3-BisphosphoglycerateFructose-1,6-BP1 HexokinaseATP 3 Phosphofructokinase-1-OHC OH 3-PhosphoglycerateH₂C-OPO,²Glucose-6-PhosphateDehydrogenase2 PhosphoglucoisomerasePyruvateTrioseH₂C-OHPhosphate Dihydroxyacetone-P C=OIsomeraseGlyceraldehyde-3-Pdehydrogenase2-PhosphoglycerateNADP NADPHA4 AldolasePhosphoglyceratekinasePhosphoenolpyruvatePhosphoglyceratemutase8 Enolase6-phosphoglucolactone.Pyruvate kinaseNon-oxidative Phase of PentosePhosphate PathwayH₂C-OPO,¹0=000-OPO,²-HC-OHH₂C-OPO,¹요。HC-OPO,H₂C-OHc=oCH₂H₂OH6-Phosphoglucolactonase6-phosphogluconate6-Phosphogluconate DehydrogenaseNADP+NADPHCO₂Ribulose-5-PhosphateThe diagram above shows two shunts from glycolysis. The first, the oxidative pentose phosphateshunt (or the hexose monophosphate pathway, HMP), generates five carbon sugars (pentoses) andNADPH. The pentoses are used in nucleotide synthesis reactions, and the NADPH is used is infatty acid synthesis and in reduction reactions. The reduction reactions are important in red bloodcells to help reduce oxidative stresses on the cell membranes.The second pathway, the Rapoport-Luebering glycolytic shunt, produces 2,3-bisphosphoglycerate,which helps to displace oxygen in red blood cells; this aids in oxygen delivery to the tissues.At least two human conditions affect glycolytic pathways: glucose 6-P dehydrogenase (G6PD)deficiency and triose phosphate isomerase (TPI) deficiency. G6PD deficiency is an X-linked disease,while the TPI gene is found on chromosome 12.

Glycolysis is the metabolic pathway that converts 1 molecule of glucose to 2 molecules of pyruvate…

TPI deficiency is a rare human condition. Patients who lack TPI cannot convert the triose dihydroxyacetone phosphate into glyceraldehyde 3-phosphate. What happens to glycolysis in TPI patients? TPI patients suffer from chronic hemolytic anemia (abnormal breakdown of red blood cells) and have variable neuromuscular dysfunctions, including muscle weakness, poor muscle tone, and atrophy. Most die of respiratory failure during childhood. Explain why TPI-deficient patients exhibit these conditions using the diagram to justify your answer. TPI is enzyme 5.

TPI deficiency is a rare human condition. Patients who lack TPI cannot convert the triose dihydroxyacetone phosphate into glyceraldehyde 3-phosphate. What happens to glycolysis in TPI patients? TPI patients suffer from chronic hemolytic anemia (abnormal breakdown of red blood cells) and have variable neuromuscular dysfunctions, including muscle weakness, poor muscle tone, and atrophy. Most die of respiratory failure during childhood. Explain why TPI-deficient patients exhibit these conditions using the diagram to justify your answer. TPI is enzyme 5.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter22: Gluconeogenesis, Glycogen Metabolism, And The Pentose Phosphate Pathway

Section: Chapter Questions

Problem 8P

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