Question 3A 50 kDa protein has a minimum radius 2.4nm, while a 20 kDa protein has a minimum radius of 1.78 nm. Based on this, which of thefollowing is likely true of the nuclear pore complex?mRNA (2 x 300 nm) would be able to pass freely through the porea protein with a radius of 1.5 nm would require a NLS for transport into the nucleusthe NPC would not allow proteins with a radius >2.5 nm to pass through freely, regardless of the protein's concentrationthe NPC allows proteins with a radius <1.78 nm to pass freely, and movement is dependent only on the protein's concentrationgradientHide Feedback for Question 3<10 KDa : passively controlled by concentration10-40 KDa : passive but regulated by calcium>40 kDa: requires active transport via importin/exportin Question 4If a cell had an over-expression of importin, it could result in increased import of proteins into the nucleus, but only if there was alsoa large enough supply of Ran-GTP in the nucleoplasm.TrueFalseHide Feedback for Question 4Ran-GTP is required for the cargo protein to be released in the nucleoplasm, and for importin to recycle back to the cytoplasm.

3 Answer the NPC would not allow proteins with a radius >2.5 nm to pass through freely,…

Answered: Question 3 A 50 kDa protein has a…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question 1. Suppose that the diagram below represents the genomic organization of an enzyme involved in eye pigment production in mice. Within the gene are four exons. Biochemical analysis has revealed that the active site of the enzyme is located in the C terminus of the protein. The nucleotide length of each exon and intron is shown. The dinucleotide sequence GT represents the 5’ splice site and the dinucleotide sequence AG represents the 3’ splice site. Both the 5’ and the 3’ splice sites must be present for splicing to occur. Assume that the first and second stop codons are located immediately after the first and second 5’ splice sites, respectively; the third and fourth stop codons are located near the 3’ end of exons 3 and 4, respectively; all these stop codons are in the correct reading frame. E) Suppose you isolate a mutant mouse that has white eyes. When you examine the size of the eye pigment enzyme produced by this mouse, you see that it is 400 amino acids long. Sequence…
QUESTION NO. 1 Much of procollagen formation occurs in the endoplasmic reticulum and Golgi apparatus which requires signal peptide. All of the following statements about targeting a protein for the ER are true except A. signal peptide usually has a positively charged N-terminus and a stretch of hydrophobic amino acids. B. signal peptide emerging from a free ribosome binds signal recognition particle (SRP). C. signal peptide is usually cleaved from the protein before the protein is inserted into the ER membrane. D. docking protein is actually an SRP receptor and serves to bind the SRP to the ER. E. SRP and docking protein do not enter the ER lumen but are recycledQUESTION NO. 2 All of the following statements about telomerase are correct except A. the RNA component acts as a template for the synthesis of a segment of DNA. B. it adds telomeric repeats to the 5'-ends of the DNA strands. C. it provides a mechanism for replicating the ends of linear…
QUESTION 12 The leucine zipper domain of transcription factors is not involved in DNA recognition but rather in facilitating dimerization. Given the chemical properties of the amino acid leucine, dimerization of transcription factors via this domain by (select the correct option). Facilitating hydrogen bonding with the aqueous environment. Chelation of bivalent ions such as Zn2+. Formation of coiled-coils through hydrophobic non-covalent interactions between evenly spaced Leu residues in alpha-helical domains. Physically connecting the two transcription factor subunits through unstructured loops.
Question 1 options: The specificity pocket of the serine protease chymotrypsin, which interacts with Tyr and Phe-containing peptide sequences, contains a Ser residue. A research group is trying to modify chymotrypsin such that it has a low KM with Trp-containing peptides. Enter the name or abbreviation of an amino acid that the Ser could be mutated to that would likely have the desired effect. (Hint: look at the diagrams of the specificity pockets shown in the course slides, and consider how the Ser would need to change to account for the difference between Tyr/Phe and Trp.)
QUESTION 22 The DNA sequences that are most conserved between human and mouse would most likely be located in: A Highly-repeated sequences, such as microsatellite regions B Highly repeated sequences, such as Alu sequences C Moderately-repeated non-coding sequences D Coding regions of single-copy genes
QUESTION 14 Which of the following best explains why there are 64 codons, but only20 amino acids for which they code? The genetic code is not ambiguous The genetic code is redundant, or degenerate There are different reading frames. RNA polymerase makes mistakes
Question 1: tRNA and amino acyl tRNA synthetases Part a: How many codons encode the amino acid Isoleucine (Ile, I)? Part b: How many codons encode the amino acid Valine (Val, V)? Part c: How many codons encode the amino acid Methionine (Met, M)? Part d: How many tRNAs decode the Ile codons? Part e: How many tRNAs decode the Val codons? Part f: How many tRNAs decode the Met codon?
QUESTION 13 Where does transcription occur in eukaryotic cells? in the nucleus in the cytoplasm at the golgi apparatus at the plasma membrane
QUESTION 16 Peptidyl transferase activity (peptide bond enzyme activity) is associated with what site in the ribosome? E P A X
Question 29 A DNA sequence is transcribed in both males and females, but only translated in males. What type of sequence is this? A. 5’ UTR B. microRNA gene C. gene on X chromosome D. alternatively spliced exon
Question 2: Part a: Complete the table describing different components of intron removal from mRNA. Nu:, X and Y refer to B-type chemistry shown on the previous page. (YELLOW table shown) Part b: Complete the table describing different components of group I self-splicing intron removal from 26S rRNA in Tetrahymena. (BLUE table shown) Part c: Draw the intron with an all atom structure for Branchpoint A after intron removal from mRNA Part d: Draw the Group I self-splicing intron with an all atom structure for the Guanosine cofactor after intron removal from 26S rRNA in Tetrahymena.
QUESTION 23 Which of the following is not part of pre-mRNA processing in eukaryotes? Addition of a 5’ cap Excision of introns Addition of a 3’ poly-A tail Excision of the promoter

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