Translocation cross Chromosome 2 plus a plece of chromosome 1 Normal chromosome 1 Centromeres of Centromeres of chromosome 1 chromosome 2 Normal Chromosome 1 chromosome 2 plus a plece of chromosome 2 Possible segregation during anaphase of melosis I KR-BB --- (a) Alternate segregation (b) Adjacent-1 segregation (C) Adjacent-2 segregation (very rare) Two normal haplold cells + 2 cells with All 4 haplold cells unbalanced All 4 haplold cells unbalanced balanced translocations Meiotic segregation of chromosomes with a reciprocal translocation. Follow the numbered centromeres through each process.(a) Alternate segregation gives rise to balanced haploid cells, whereas (b) adjacent-1 segregation and (c) adjacent-2 segregation produce haploid cells with an unbalanced amount of genetic material. 2.

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Chapter6: Cytogenetics: Karyotypes And Chromosome Aberrations
Section: Chapter Questions
Problem 3QP: A colleague e-mails you saying that she has identified an interesting chromosome variation at 21q13....
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Explain why these chromosomes form a translocation cross during prophase of meiosis I?

Translocation cross
Chromosome 2
plus a plece of
chromosome 1
Normal
chromosome 1
Centromeres of
Centromeres of
chromosome 1
chromosome 2
Normal
Chromosome 1
chromosome 2
plus a plece of
chromosome 2
Possible segregation during anaphase of melosis I
KR-BB
---
(a) Alternate segregation
(b) Adjacent-1 segregation
(C) Adjacent-2 segregation (very rare)
Two normal haplold cells
+ 2 cells with
All 4 haplold cells
unbalanced
All 4 haplold cells
unbalanced
balanced translocations
Meiotic segregation of chromosomes with a reciprocal translocation. Follow the numbered centromeres through each
process.(a) Alternate segregation gives rise to balanced haploid cells, whereas (b) adjacent-1 segregation and (c) adjacent-2
segregation produce haploid cells with an unbalanced amount of genetic material.
2.
Transcribed Image Text:Translocation cross Chromosome 2 plus a plece of chromosome 1 Normal chromosome 1 Centromeres of Centromeres of chromosome 1 chromosome 2 Normal Chromosome 1 chromosome 2 plus a plece of chromosome 2 Possible segregation during anaphase of melosis I KR-BB --- (a) Alternate segregation (b) Adjacent-1 segregation (C) Adjacent-2 segregation (very rare) Two normal haplold cells + 2 cells with All 4 haplold cells unbalanced All 4 haplold cells unbalanced balanced translocations Meiotic segregation of chromosomes with a reciprocal translocation. Follow the numbered centromeres through each process.(a) Alternate segregation gives rise to balanced haploid cells, whereas (b) adjacent-1 segregation and (c) adjacent-2 segregation produce haploid cells with an unbalanced amount of genetic material. 2.
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