Two ligands have 1000-times different affinities for the same binding site. They differ by a single chemical group. What is a reasonable candidate for the group? ∆G=RT lnKd KD=[A][B]/[A.B] each 10-fold in affinity is equal to 5.9 kJ/mol (at 37C)

Chemistry: The Molecular Science
5th Edition
ISBN:9781285199047
Author:John W. Moore, Conrad L. Stanitski
Publisher:John W. Moore, Conrad L. Stanitski
Chapter20: Chemistry Of Selected Transition Elements And Coordination Compounds
Section: Chapter Questions
Problem 125QRT: Two different compounds are known with the formula Pd(py)2Cl2, but there is only one compound with...
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Two ligands have 1000-times different affinities for the same binding site. They differ by a single chemical group. What is a reasonable candidate for the group? ∆G=RT lnKd KD=[A][B]/[A.B] each 10-fold in affinity is equal to 5.9 kJ/mol (at 37C)
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