Uncharged molecules can passively pass through membranes more readily than charged molecules. Acetylsalicylic acid, better known as aspirin, has a single carboxylate group with a pKa of 3.5. Approximately what percentage of the molecule is charged in the stomach, and approximately what percentage is charged at normal blood pH at the surface of a blood vessel? Finally, per unit surface area, where would the rate of passive transfer across a membrane be highest? A.) 1%, >99%, stomach B.) >99%, 1%, stomach C.) 1%, >99%, blood vessel D.) 50%, 50%, blood vessel E.)>99%, 1%, blood vessel F.) 50%, 50%, stomach
Uncharged molecules can passively pass through membranes more readily than charged molecules. Acetylsalicylic acid, better known as aspirin, has a single carboxylate group with a pKa of 3.5. Approximately what percentage of the molecule is charged in the stomach, and approximately what percentage is charged at normal blood pH at the surface of a blood vessel? Finally, per unit surface area, where would the rate of passive transfer across a membrane be highest? A.) 1%, >99%, stomach B.) >99%, 1%, stomach C.) 1%, >99%, blood vessel D.) 50%, 50%, blood vessel E.)>99%, 1%, blood vessel F.) 50%, 50%, stomach
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Uncharged molecules can passively pass through membranes more readily than charged molecules. Acetylsalicylic acid, better known as aspirin, has a single carboxylate group with a pKa of 3.5. Approximately what percentage of the molecule is charged in the stomach, and approximately what percentage is charged at normal blood pH at the surface of a blood vessel? Finally, per unit surface area, where would the rate of passive transfer across a membrane be highest?
A.) 1%, >99%, stomach
B.) >99%, 1%, stomach
C.) 1%, >99%, blood vessel
D.) 50%, 50%, blood vessel
E.)>99%, 1%, blood vessel
F.) 50%, 50%, stomach
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