Unlike a rabbit, running all-out for a few moments to escape a predator, migratory birds require energy for extended periods of time. For example, ducks generally fly several thousand miles during their annual migration. The flight muscles of migratory birds have a high oxidative capacity and obtain the necessary ATP through the oxidation of acetyl-CoA (obtained from fats) via the citric acid cycle. Compare the regulation of muscle glycolysis during short-term intense activity, as in a fleeing rabbit, and during extended activity, as in the migrating duck. Why must the regulation in these two settings be different? Extended activity requires the highly efficient anaerobic metabolism of fats, rather than the less efficient aerobic metabolism of glucose. Extended activity requires the highly efficient aerobic oxidation of fats, rather than the less efficient anaerobic metabolism of glucose. Extended activity stimulates glycolysis because the concentrations of citrate and acetyl-CoA are low. Extended activity depletes muscle glycogen in 12 to 24 hours, resulting in the animal depending on liver glycogen.

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter19: The Tricarboxylic Acid Cycle
Section: Chapter Questions
Problem 21P: Complete oxidation of a 16-carbon fatty acid can yield 129 molecules of ATP Study Figure 19.2 and...
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Unlike a rabbit, running all-out for a few moments to escape a predator, migratory birds require energy for extended periods of
time. For example, ducks generally fly several thousand miles during their annual migration. The flight muscles of migratory
birds have a high oxidative capacity and obtain the necessary ATP through the oxidation of acetyl-CoA (obtained from fats) via
the citric acid cycle. Compare the regulation of muscle glycolysis during short-term intense activity, as in a fleeing rabbit, and
during extended activity, as in the migrating duck.
Why must the regulation in these two settings be different?
Extended activity requires the highly efficient anaerobic metabolism of fats, rather than the less efficient aerobic
metabolism of glucose.
Extended activity requires the highly efficient aerobic oxidation of fats, rather than the less efficient anaerobic
metabolism of glucose.
Extended activity stimulates glycolysis because the concentrations of citrate and acetyl-CoA are low.
Extended activity depletes muscle glycogen in 12 to 24 hours, resulting in the animal depending on liver glycogen.
Transcribed Image Text:Unlike a rabbit, running all-out for a few moments to escape a predator, migratory birds require energy for extended periods of time. For example, ducks generally fly several thousand miles during their annual migration. The flight muscles of migratory birds have a high oxidative capacity and obtain the necessary ATP through the oxidation of acetyl-CoA (obtained from fats) via the citric acid cycle. Compare the regulation of muscle glycolysis during short-term intense activity, as in a fleeing rabbit, and during extended activity, as in the migrating duck. Why must the regulation in these two settings be different? Extended activity requires the highly efficient anaerobic metabolism of fats, rather than the less efficient aerobic metabolism of glucose. Extended activity requires the highly efficient aerobic oxidation of fats, rather than the less efficient anaerobic metabolism of glucose. Extended activity stimulates glycolysis because the concentrations of citrate and acetyl-CoA are low. Extended activity depletes muscle glycogen in 12 to 24 hours, resulting in the animal depending on liver glycogen.
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