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What characteristics in a human pedigree suggest
a mitochondrial location for a mutation affecting
the trait?
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- From the pedigree in Figure 3-25, what principle can youdeduce about the inheritance of mitochondrial diseasefrom affected fathers?Mitochondrial genomes in different organisms varygreatly Why?Which of the pedigrees shown above could be one showing the inheritance of a non-lethal mitochondrial disease?
- a. Explain the difference between maternal inheritanceof organelle DNAs and maternal effect inheritance.b. How do the inheritance patterns of phenotypescaused by mitochondrial genes differ from thosecaused by maternal effect genes?Wooly hair is a rare dominant trait found in people of Scandinavian descent in which the hair resembles the wool of a sheep. Amale with wooly hair, who has a mother with straight hair, movesto an island that is inhabited by people who are not of Scandinavian descent. Assuming that no other Scandinavians immigrate tothe island, what is the probability that a great-grandchild of thismale will have wooly hair? (Hint: You may want to draw a pedigree to help you figure this out.) If this wooly-haired male haseight great-grandchildren, what is the probability that one out ofeight will have wooly hair?The accompanying pedigree shows a very unusual inheritance pattern that actually did exist. All progeny areshown, but the fathers in each mating have been omittedto draw attention to the remarkable pattern.a. Concisely state exactly what is unusual about thispedigree.b. Can the pattern be explained by Mendelianinheritance?
- What feature(s) of this pedigree indicate(s) dominant inheritance?Describe how a biparental pattern of extranuclear inheritance couldresemble a Mendelian pattern of inheritance for a particular gene.How would they differ?. Tay-Sachs disease is a rare human disease in which toxic substances accumulate in nerve cells. The recessiveallele responsible for the disease is inherited in a simpleMendelian manner. For unknown reasons, the allele ismore common in populations of Ashkenazi Jews ofeastern Europe. A woman is planning to marry her firstcousin, but the couple discovers that their sharedgrandfather’s sister died in infancy of Tay-Sachsdisease.a. Draw the relevant parts of the pedigree, and showall the genotypes as completely as possible.b. What is the probability that the cousins’ first childwill have Tay-Sachs disease, assuming that all peoplewho marry into the family are homozygous normal?