What is the Characteristic pedigree for mitochondrial disease?
The genes located on the nuclear chromosomes obey the Mendelian law of inheritance. In the human being, the nuclear genome carries most of the generation information of the individual which get inherited from one generation to the next generation however certain characteristics are transmitted by non-mendelian fashion as these genes are located on another site in the cell, such as mitochondria in animals and chloroplast in plants, such inheritance is called cytoplasmic inheritance or extranuclear inheritance. During fertilization, the fetus receives half of the genetic material from his male parent while the half genetic material plus complete cytoplasm from the mother, the cytoplasmic inheritance is always maternal.
The pedigree is a diagrammatic representation of the inheritance of genes across the family. The representation of mitochondrial inheritance would be quite different from the regular nuclear inheritance as it does not follow the law of Mendel's inheritance.
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