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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 4.7, Problem 2EG
Textbook Problem
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Which members of the pedigree could have been carriers, and which might have been the source of the mutation?

Chapter 4.7, Problem 2EG, Which members of the pedigree could have been carriers, and which might have been the source of the

Summary Introduction

To determine: The members of pedigree that could be a carrier of the mutant gene for hemophilia.

Introduction: According to the pedigree analysis, Queen Victoria of England carried the gene for X-linked recessive disorder hemophilia. This mutant allele was passed to several generations in the royal houses of Europe. However, now the royal family of Europe is free from hemophilia.

Explanation of Solution

Hemophilia is an X-linked recessive disorder. A female carries two X chromosomes and a male carries one X and one Y chromosomes. The transmission of only one mutant X-chromosome in the male can cause the diseased condition. In the case of a recessive trait, if the female receives a mutant allele from the mother, she can become a carrier of the disease. In case, if the female receives both mutant alleles, then the disease can develop...

Summary Introduction

To explain: The members of pedigree that could be a source of mutation.

Introduction: According to the pedigree analysis, Queen Victoria of England carried the gene for X-linked recessive disorder hemophilia. This mutant allele was passed to several generations in the royal houses of Europe. However, now the royal family of Europe is free from hemophilia.

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