What is the rate-determining step in the alkaline hydrolysis of an amide (reaction shown below) H₂O/OH- NH3 he at NH₂ Select one: A. Bonding of OH- nucleophile to carbonyl carbon. B. Protonation of -NH₂ group in tetrahedral intermediate. C. Ejection of NH3 from a tetrahedral intermediate. D. Bonding of H₂O nucleophile to carbonyl carbon. E. Ejection of NH₂¯ from a tetrahedral intermediate.

What is the rate-determining step in the alkaline hydrolysis of an amide (reaction shown below) H₂O/OH- NH3 he at NH₂ Select one: A. Bonding of OH- nucleophile to carbonyl carbon. B. Protonation of -NH₂ group in tetrahedral intermediate. C. Ejection of NH3 from a tetrahedral intermediate. D. Bonding of H₂O nucleophile to carbonyl carbon. E. Ejection of NH₂¯ from a tetrahedral intermediate.

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter19: Eas: Electrophilic Aromatic Substitution

Section: Chapter Questions

Problem 45E

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