Which of the following is most likely to cause accumulation of acetyl CoA? Group of answer choices There is not enough oxaloacetate present to run the citric acid cycle Increase activity of pyruvate dehydrogenase kinase Increased fatty acid synthesis Increased citrate synthase activity When fluoroacetate (an analog of acetate) is added to the mitochondria, it causes build up of fluorocitrate. Which of the following is most likely to be true? Group of answer choices Fluoroacetate cannot be converted to fluoroacetyl CoA Fluoroacetyl CoA cannot be combined with oxaloacetate to enter the citric acid cycle Addition of fluoroacetate will cause an increase in isocitrate Aconitase cannot use fluorocitrate as a substrate

Which of the following is most likely to cause accumulation of acetyl CoA? Group of answer choices There is not enough oxaloacetate present to run the citric acid cycle Increase activity of pyruvate dehydrogenase kinase Increased fatty acid synthesis Increased citrate synthase activity When fluoroacetate (an analog of acetate) is added to the mitochondria, it causes build up of fluorocitrate. Which of the following is most likely to be true? Group of answer choices Fluoroacetate cannot be converted to fluoroacetyl CoA Fluoroacetyl CoA cannot be combined with oxaloacetate to enter the citric acid cycle Addition of fluoroacetate will cause an increase in isocitrate Aconitase cannot use fluorocitrate as a substrate

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...

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Understanding the Mechanism of Hemolytic Anemia Genetic defects in glycolytic enzymes can have serious consequences for humans For example, defects in the gene for pyruvate kinase can result in a condition known as hemolytic anemia. Consult a reference to learn about hemolytic anemia, and discuss why such genetic defects lead to this condition.
Elevated levels of acetyl-CoA will act as an effector for which of the following enzymes? more than one can be correct Pyruvate carboxylase. Pyruvate kinase Pyruvate dehydrogenase. Citrate synthase a-Ketoglutarate dehydrogenase.
Which of the following is NOT a metabolic fate of pyruvate? The pyruvate dehydrogenase complex catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. Pyruvate carboxylase catalyzes the carboxylation of pyruvate to form oxaloacetate. Pyruvate kinase catalyzes the formation of phosphoenolpyruvate from pyruvate. Lactate dehydrogenase catalyzes the formation of lactate from pyruvate.
Which of the following citric acid cycle enzymes catalyzes substrate-level phosphorylation? A) isocitrate dehydrogenase B) α-ketoglutarate dehydrogenase C) succinyl CoA synthetase D) succinate dehydrogenase E) malate dehydrogenase
A fatty acid (a long straight-chain carboxylic acid with an even number of carbons) is metabolized to acetylCoA, which can then enter the citric acid cycle to be further metabolized. A fatty acid with an odd number of carbons is metabolized to acetyl-CoA and one equivalent of propionyl-CoA. Propionyl-CoA cannot enter the citric acid cycle. Two coenzyme-requiring enzymes are needed to convert it to succinyl-CoA, a compound that can enter the citric acid cycle. Write the two enzyme-catalyzed reactions and include the names of the required coenzymes.
Each of the following citric acid cycle enzymes catalyzes electron transfer to NADH/FADH2 except A) isocitrate dehydrogenase. B) α-ketoglutarate dehydrogenase. C) succinyl CoA synthetase. D) succinate dehydrogenase. E) malate dehydrogenase.
Which of the following reactions required dihydrolipoyl dehydrogenase? Oxidative decarboxylation of pyruvate Oxidative decarboxylation of a-ketoglutarate Both A and B Neither A nor B Fatty acid biosynthesis is stimulated by: Decreased levels of citrate Increased levels of palmitoyl-CoA Increased levels epinephrine Increased levels of AMP All of the above None of the above
alpha-ketoglutarate dehydrogenase will do which of the following: Select one: a. Pyruvate is decarboxylated to become acetyl-CoA producing NADH and Carbon dioxide b. Succinate is oxidized to become fumarate forming FADH2 c. Succinyl-CoA becomes Succinate and forms one ATP molecule and Coenzyme A-SH d. Oxaloacetate combines with the acetyl from acetyl-CoA to produce Citric acid(citrate) e. Malate is oxidized to become oxaloacetate forming NADH f. Isocitrate and then decarboxylated and oxidized to produce alpha-ketoglutarate, Carbon dioxide and NADH g. Citrate is rearranged to become Isocitrate h. Fumarate is combined with water to become Malate i. alpha-ketoglutarate is oxidized and decarboxylated to produce Succinyl-CoA, Carbon dioxide and NADH
Which of the following is NOT a component of the pyruvate dehydrogenase complex? a. dihydrolipoyl dehydrogenase b. dihydrolipoyl transacetylase c. pyruvate dehydrogenase d. dihydrolipoyl catalase
Which of the following glycolytic enzymes catalyzes the conversion of fructose-1,6-bisphosphate into the two product molecules dihydroxyacetone phosphate, and glyceraldehyde-3-phosphate? phosphoglycerate kinase pyruvate kinase malate dehydrogenase aldolase phosphofructokinase
3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) is a very long name for the enzyme that is involved in the production of cholesterol in the human liver. The enzyme catalyzes a reaction in which electrons are exchanged between reactants to form products. This an example of which of the following chemical reactions that are involved in maintaining homeostasis? HMG-CoA reductase catalyzes a catabolic reaction because electrons are exchanged between the reactants to form products. HMG-CoA reductase catalyzes a specific type of exchange reaction called an oxidation-reduction reaction in which electrons are exchanged between reactants to form products. HMG-CoA reductase catalyzes an anabolic reaction because electrons are exchanged between the reactants to form products. HMG-CoA reductase catalyzes a specific type of oxidation-reduction reaction called an exchange reaction in which atoms are exchanged between reactants to form products. Like most enzymes, HMG-CoA reductase…
The acyl-CoA dehydrogenase deficiency diseases are a groupof inherited defects that impair the b-oxidation of fatty acids.Symptoms of the disease range from nausea and vomiting tofrequent comas. Symptoms may be alleviated by eating regularly and avoiding periods of starvation (12 hours or more).Why does this simple procedure alleviate the symptoms?