Which one of the following nucleophiles will give mainly direct (1,2) addition in its reaction with the following conjugated enone? 8. a) CH;MgBr b) HBr c) CH3SH d) (CH3)½CULI
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- Select which molecule is the better nucleophile in the following pair: a). Br− or Cl− in H2O b). CH3O− or CH3OH in H2O c). HO− or HS− in H2O d). I− or Br− in H2O1. Which of the following is the strongest nucleophile? Refer to the diagram below with an MeOH, MeSH, etc. 2. Which of the following is true about the stereochemistry of SN1 reaction?a.retention of configuration at the electrophilic centerb.50:50 mixture of retention and inversion of configuration at the electrophilic centerc.inversion of configuration at the electrophilic centerd. slightly more inversion than retention at the electrophilic centerRank the following compounds in order of increasing SN2 reaction rate with a good nucleophile. Explain yourreasoning. (CH3)2CHBr (CH3)3CBr CH3CH2Br CH3CH2I
- 34. E2 is bimolecular which means: both the nucleophile and the product take part in the step whose kinetics are measured both the nucleophile and the alkyl halide take part in the step whose kinetics are measured both the product and the alkyl halide take part in the step whose kinetics are measured None of the aboveIn the reaction of 1-iodopropane with the hydroxide ion in DMSO how will the rate of reaction change if the concentration of the substrate and nucleophile were each halved? A. The rare will increase by a factor of 4 B. The rate will be reduced by a factor of 1/ 4 C. The rate will be halved. D. The rate will doubleRank in terms of reactivity towards the nucleophile. 1=least 4=most
- What nucleophiles would form the following compounds as a result of reacting with 1-iodobutane?How does each of the following changes affect the rate of an E1 reaction?d.) Changing the leaving group from Cl- to Br-e.) Changing the solvent from DMSO to CH3OHFor problem 8.17, all of the reactions will be SN2. For each reaction, identify and evaluate each nucleophile (strong? weak? Strong or weak as a base?) Also, evaluate each solvent as polar protic or polar aprotic. I recommend drawing the structure of each solvent. (d) Sodium cyanide in dimethyl sulfoxide (e) Sodium azide in aqueous ethanol (f) Sodium hydrogen sulfide in ethanol
- How does changing the alkyl halide from CH3CH2Br to (CH3)2CHBr affect the rate of an E2 reaction?Would you expect acetate ion (CH3CO2 -) to be a better nucleophile in an SN2 reaction with an alkyl halide carried out in methanol or in dimethyl sulfoxideRank the nucleophiles in following group in order of increasing nucleophilicity. H2O, −OH, CH3CO2-