While R256T and K364R are at different positions, both mutations are present in the active site. Researchers were unable to get kinetics data on R256T. What does this tell you about its ability to function properly? Why might K364R be tolerated better than R256T?

While R256T and K364R are at different positions, both mutations are present in the active site. Researchers were unable to get kinetics data on R256T. What does this tell you about its ability to function properly? Why might K364R be tolerated better than R256T?

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter26: Synthesis And Degradation Of Nucleotides

Section: Chapter Questions

Problem 6P: Allosteric Regulation of Ribonucleotide Reductase by ATP and Deoxynucleotides Describe the...

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Q9
While R256T and K364R are at different positions, both mutations are
present in the active site. Researchers were unable to get kinetics
data on R256T. What does this tell you about its ability to function
properly? Why might K364R be tolerated better than R256T?

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