Structural similarity between the SARS-CoV-2 Mpro protease and chymotrypsin suggests that they would use the same catalytic mechanisms. What feature of the active site would you expect to find in Mpro that would be important in stabilizing the transition state? Describe how that feature would act to stabilize the transition state.

Structural similarity between the SARS-CoV-2 Mpro protease and chymotrypsin suggests that they would use the same catalytic mechanisms. What feature of the active site would you expect to find in Mpro that would be important in stabilizing the transition state? Describe how that feature would act to stabilize the transition state.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter26: Synthesis And Degradation Of Nucleotides

Section: Chapter Questions

Problem 13P

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