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Why does it make sense that under conditions of low ATP levels in the cell the pyruvate carboxylase reaction is activated by acetyl-Coenzyme A, whereas the pyruvate dehydrogenase reaction is activated by Coenzyme A under these same conditions? When acetyl-Coenzyme A levels build-up, then pyruvate carboxylase generates oxaloacetate for the citrate synthase reaction, whereas when Coenzyme A builds up, then acetyl-Coenzyme A needs to be generated by pyruvate dehydrogenase to maintain flux through the citrate cycle. When Coenzyme A levels build-up, then pyruvate dehydrogenase generates oxaloacetate for the citrate synthase reaction, whereas when acetyl-Coenzyme A builds up, then Coenzyme A needs to be generated by pyruvate carboxylase to maintain flux through the citrate cycle. Oxaloacetate is needed for the citrate synthase reaction, but acetyl-Coenzyme A is needed for the pyruvate dehydrogenase reaction, so it is actually under conditions of low ATP levels that these enzymes are activated acetyl-Coenzyme A and Coenzyme A, respectively. Oxaloacetate is required for mitochondrial shuttle systems, and therefore it makes sense to activate pyruvate carboxylase by acetyl-Coenzyme A to stimulate export of oxaloacetate, which in turn produces more Coenzyme A to activate pyruvate dehydrogenase.

Why does it make sense that under conditions of low ATP levels in the cell the pyruvate carboxylase reaction is activated by acetyl-Coenzyme A, whereas the pyruvate dehydrogenase reaction is activated by Coenzyme A under these same conditions? When acetyl-Coenzyme A levels build-up, then pyruvate carboxylase generates oxaloacetate for the citrate synthase reaction, whereas when Coenzyme A builds up, then acetyl-Coenzyme A needs to be generated by pyruvate dehydrogenase to maintain flux through the citrate cycle. When Coenzyme A levels build-up, then pyruvate dehydrogenase generates oxaloacetate for the citrate synthase reaction, whereas when acetyl-Coenzyme A builds up, then Coenzyme A needs to be generated by pyruvate carboxylase to maintain flux through the citrate cycle. Oxaloacetate is needed for the citrate synthase reaction, but acetyl-Coenzyme A is needed for the pyruvate dehydrogenase reaction, so it is actually under conditions of low ATP levels that these enzymes are activated acetyl-Coenzyme A and Coenzyme A, respectively. Oxaloacetate is required for mitochondrial shuttle systems, and therefore it makes sense to activate pyruvate carboxylase by acetyl-Coenzyme A to stimulate export of oxaloacetate, which in turn produces more Coenzyme A to activate pyruvate dehydrogenase.

Biochemistry
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter19: The Tricarboxylic Acid Cycle
Section: Chapter Questions
Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...
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Why does it make sense that under conditions of low ATP levels in the cell the pyruvate carboxylase reaction is activated by acetyl-Coenzyme A, whereas the pyruvate dehydrogenase reaction is activated by Coenzyme A under these same conditions? When acetyl-Coenzyme A levels build-up, then pyruvate carboxylase generates oxaloacetate for the citrate synthase reaction, whereas when Coenzyme A builds up, then acetyl-Coenzyme A needs to be generated by pyruvate dehydrogenase to maintain flux through the citrate cycle. When Coenzyme A levels build-up, then pyruvate dehydrogenase generates oxaloacetate for the citrate synthase reaction, whereas when acetyl-Coenzyme A builds up, then Coenzyme A needs to be generated by pyruvate carboxylase to maintain flux through the citrate cycle. Oxaloacetate is needed for the citrate synthase reaction, but acetyl-Coenzyme A is needed for the pyruvate dehydrogenase reaction, so it is actually under conditions of low ATP levels that these enzymes are activated acetyl-Coenzyme A and Coenzyme A, respectively. Oxaloacetate is required for mitochondrial shuttle systems, and therefore it makes sense to activate pyruvate carboxylase by acetyl-Coenzyme A to stimulate export of oxaloacetate, which in turn produces more Coenzyme A to activate pyruvate dehydrogenase.
Transcribed Image Text:Why does it make sense that under conditions of low ATP levels in the cell the pyruvate carboxylase reaction is activated by acetyl-Coenzyme A, whereas the pyruvate dehydrogenase reaction is activated by Coenzyme A under these same conditions? When acetyl-Coenzyme A levels build-up, then pyruvate carboxylase generates oxaloacetate for the citrate synthase reaction, whereas when Coenzyme A builds up, then acetyl-Coenzyme A needs to be generated by pyruvate dehydrogenase to maintain flux through the citrate cycle. When Coenzyme A levels build-up, then pyruvate dehydrogenase generates oxaloacetate for the citrate synthase reaction, whereas when acetyl-Coenzyme A builds up, then Coenzyme A needs to be generated by pyruvate carboxylase to maintain flux through the citrate cycle. Oxaloacetate is needed for the citrate synthase reaction, but acetyl-Coenzyme A is needed for the pyruvate dehydrogenase reaction, so it is actually under conditions of low ATP levels that these enzymes are activated acetyl-Coenzyme A and Coenzyme A, respectively. Oxaloacetate is required for mitochondrial shuttle systems, and therefore it makes sense to activate pyruvate carboxylase by acetyl-Coenzyme A to stimulate export of oxaloacetate, which in turn produces more Coenzyme A to activate pyruvate dehydrogenase.
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