With regard to the glyceraldehyde-3-phosphate dehydrogenase enzyme reaction: a) Write the mechanism of the reaction. b) What two enzyme intermediates are involved? One undergoes an oxidation-reduction step. What is oxidized and what is reduced? How are the electrons transferred? The second intermediate has some different chemistry than usual esters. Comment. c) What factors are operating here to bring about the catalysis that this enzyme carries out?

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter17: Metabolism: An Overview
Section: Chapter Questions
Problem 14P
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With regard to the glyceraldehyde-3-phosphate dehydrogenase enzyme reaction:
a) Write the mechanism of the reaction.
b) What two enzyme intermediates are involved? One undergoes an oxidation-reduction step.
What is oxidized and what is reduced? How are the electrons transferred? The second
intermediate has some different chemistry than usual esters. Comment.
c) What factors are operating here to bring about the catalysis that this enzyme carries out?
d) The product of this reaction is “rather special”. Comment

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