Write an equation balancing the electrical potential and chemical potential for 3 Na+ and 1 Ca2+. Note that NCX is an antiporter, whereas SGLT1 is a symporter, thus the maximal electrochemical gradient of Ca2+ will be opposite that of glucose. ii. Rearrange this equation in to give intra-cellular Ca2+ as a function of extra-cellular Ca2+, intra-cellular and extra-cellular Na+, resting membrane potential. You should note the equation and substitution below. iii. Use the values below for extra-cellular Ca2+, intra-cellular and extra-cellular Na+, resting membrane potential to calculate intra-cellular Ca2+. Extracellular Na+ concentration is 140mM, intracellular Na+ concentration is 12mM, extracellular Ca2+ concentration 2.5mM, and the resting membrane potential is -65mV.
i. Write an equation balancing the electrical potential and chemical potential for 3 Na+ and 1 Ca2+. Note that NCX is an antiporter, whereas SGLT1 is a symporter, thus the maximal
ii. Rearrange this equation in to give intra-cellular Ca2+ as a function of extra-cellular Ca2+, intra-cellular and extra-cellular Na+, resting membrane potential. You should note the equation and substitution below.
iii. Use the values below for extra-cellular Ca2+, intra-cellular and extra-cellular Na+, resting membrane potential to calculate intra-cellular Ca2+.
Extracellular Na+ concentration is 140mM, intracellular Na+ concentration is 12mM, extracellular
Ca2+ concentration 2.5mM, and the resting membrane potential is -65mV.
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