You are interested in how CAMP-dependent protein kinase A (PKA) functions to affect learning and memory, and you decide to study its function in the brain. It is known that, in the cells you are studying, PKA is an effecter protein of a GPCR signaling pathway that stimulates adenylyl cyclase. It is also known that activated PKA phosphorylates the transcriptional regulator called Nerd that then activated transcription of the gene Brainy. Explain the effect of a mutation in the gene that encodes for adenylyl cyclase that renders it unable to interact with the a subunit of the G protein.

You are interested in how CAMP-dependent protein kinase A (PKA) functions to affect learning and memory, and you decide to study its function in the brain. It is known that, in the cells you are studying, PKA is an effecter protein of a GPCR signaling pathway that stimulates adenylyl cyclase. It is also known that activated PKA phosphorylates the transcriptional regulator called Nerd that then activated transcription of the gene Brainy. Explain the effect of a mutation in the gene that encodes for adenylyl cyclase that renders it unable to interact with the a subunit of the G protein.

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...

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