Thyroid hormone receptor (TR) regulates growth, development, and differentiation of mammals. TR contains both a domain that binds to T3, the thyroid hormone, and a separate domain that binds to DNA. Which of the following BEST explains how TR signals?   A. T3 binds to TR at the cell membrane, which then releases second messengers to regulate gene expression.   B. T3 binds to DNA at the cell membrane, which then releases second messengers to regulate gene expression.   C. T3 diffuses through the cell membrane to bind to TR, which then binds to DNA to regulate gene expression.   D. T3 diffuses through the cell membrane to bind to DNA, which then binds to TR to regulate gene expression.

Biology (MindTap Course List)
11th Edition
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
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Chapter6: Cell Communication
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Thyroid hormone receptor (TR) regulates growth, development, and differentiation of mammals. TR contains both a domain that binds to T3, the thyroid hormone, and a separate domain that binds to DNA. Which of the following BEST explains how TR signals?

  •  
    A.

    T3 binds to TR at the cell membrane, which then releases second messengers to regulate gene expression.

  •  
    B.

    T3 binds to DNA at the cell membrane, which then releases second messengers to regulate gene expression.

  •  
    C.

    T3 diffuses through the cell membrane to bind to TR, which then binds to DNA to regulate gene expression.

  •  
    D.

    T3 diffuses through the cell membrane to bind to DNA, which then binds to TR to regulate gene expression.

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