You are studying a protein called Protein C, which is a drug target for cancer, as inhibiting its activation might stop unwarranted cell division. Drug D binds to protein C with an affinity (∆G°) of -30 kJ/mol at 310K. Suppose that in the human body, [C] is 1*10-6M. What initial concentration of drug D would you want to administer such that, at equilibrium, half of the targets (protein C) are bound by drug?
You are studying a protein called Protein C, which is a drug target for cancer, as inhibiting its activation might stop unwarranted cell division. Drug D binds to protein C with an affinity (∆G°) of -30 kJ/mol at 310K. Suppose that in the human body, [C] is 1*10-6M. What initial concentration of drug D would you want to administer such that, at equilibrium, half of the targets (protein C) are bound by drug?
Chemistry & Chemical Reactivity
10th Edition
ISBN:9781337399074
Author:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Chapter14: Chemical Kinetics: The Rates Of Chemical Reactions
Section14.7: Reaction Mechanisms
Problem 1.2ACP
Related questions
Question
You are studying a protein called Protein C, which is a drug target for cancer, as inhibiting its activation might stop unwarranted cell division. Drug D binds to protein C with an affinity (∆G°) of -30 kJ/mol at 310K. Suppose that in the human body, [C] is 1*10-6M. What initial concentration of drug D would you want to administer such that, at equilibrium, half of the targets (protein C) are bound by drug?
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 4 steps with 4 images
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Recommended textbooks for you
Chemistry & Chemical Reactivity
Chemistry
ISBN:
9781337399074
Author:
John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:
Cengage Learning
Chemistry by OpenStax (2015-05-04)
Chemistry
ISBN:
9781938168390
Author:
Klaus Theopold, Richard H Langley, Paul Flowers, William R. Robinson, Mark Blaser
Publisher:
OpenStax
Chemistry & Chemical Reactivity
Chemistry
ISBN:
9781337399074
Author:
John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:
Cengage Learning
Chemistry by OpenStax (2015-05-04)
Chemistry
ISBN:
9781938168390
Author:
Klaus Theopold, Richard H Langley, Paul Flowers, William R. Robinson, Mark Blaser
Publisher:
OpenStax
Chemistry: The Molecular Science
Chemistry
ISBN:
9781285199047
Author:
John W. Moore, Conrad L. Stanitski
Publisher:
Cengage Learning
Chemistry for Today: General, Organic, and Bioche…
Chemistry
ISBN:
9781305960060
Author:
Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:
Cengage Learning
