Chapter 1, Problem 9P

The most common chemical route of entry is: a. ingestion b. inhalation c. skin / eye contact d. İnjection The oral rat LD50 is a commonly used index of: a.flammability b. corrosivity c. carcinogenicity d. acute toxicity Every lab must have a chemical hygiene plan (CHP) and Material Safety Data Sheets (MSDS). a.true b. False

1.      A 75-year-old man is given an infusion of lidocaine for the control of ventricular tachycardia. A dose adjustment is required. Which of the following parameters would be the most important in selecting a new infusion rate that is therapeutically effective but non-toxic?   A.    Bioavailability B.     Clearance C.     Glomerular filtration rate D.    Volume of distribution       1.      A 15-year-old girl has severe cramping pain that begins a few hours before the start of her menstrual flow. She says that the pain has occurred monthly for the past 9 months. She also complains of headache and of being very tired during the menstrual period. Which of the following is the most appropriate therapy?   A.    Acetaminophen B.     Celecoxib C.     Dexamethasone   D.    Ibuprofen

Case Studies An 18-year-old male high school student who had a 4-year history of diabetes mellitus was brought to the emergency department because of excessive drowsiness, vomiting. and diarrhea. His diabetes had been well controlled with 40 units of NPH insulin daily until several days ago when he developed excessive thirst and polyuria. For the past 3 days, he has also had headaches, myalgia, and a low-grade fever. Diarrhea and vomiting began 1 day ago Chemistry Test Results Sodium 126 mmol/L Urinalysis Results Specific 1.012 gravity pH 5.0 Glucose 4+ Ketone Large Potassium Chloride Bicarbonate Plasma glucose 6.1 mmol/L 87 mmol/L 6 mmol/L 600 mg/dL BUN Creatinine Serum ketones 48 mg/dL. 2.0 mg/dL 4+ 1. What is the probable diagnosis of this patient 2. What laboratory test(s) should be performed to follow this patient and aid in adjusting insulin levels? 3. Why are the urine ketones positive? 4. What methods are used to quantitate urine ketones? Which ketone(s) do they detect?