ACCESS IN MOODLE ROOMS
ACCESS IN MOODLE ROOMS
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ISBN: 9780135333457
Author: Pearson
Publisher: PEARSON
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Chapter 25, Problem 1AQ

Coagulase is a virulence factor for Staphylococcus aureus that acts by causing clot formation at the site of S. aureus growth. Streptokinase is a virulence factor for Streptococcus pyogenes that acts by dissolving clots at the site of S. pyogenes growth. Reconcile these opposing strategies for enhancing pathogenicity.

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Summary Introduction

To explain:

The virulent effect of coagulase and streptokinase for enhancing pathogenicity.

Concept introduction:

Coagulase and streptokinase are the virulence factors released by Staphylococcus aureus and Streptococcus pyogenes respectively. Coagulase helps in the process of clot formation thereby protecting the colony of S. aureus cells from the host immune response. Streptokinase helps in dissolving the clot for the further spread and growth of the micro-organism. Coagulase and streptokinase works antagonistically in the process of blood clotting.

Explanation of Solution

Pictorial representation: The figure depicting the action of Coagulase and Streptokinase is represented as follows:

ACCESS IN MOODLE ROOMS, Chapter 25, Problem 1AQ

Fig.1: The mode of action of Coagulase and Streptokinase.

Staphylococcus aureus enters the wound and help in the conversion of “fibrinogen to fibrin” thereby resulting the formation of clot and protection of S. aureus cells. Streptokinase released by Streptococcus pyogenes help in dissolving the clot and spreading the proliferation of the microorganism in different cells and tissues.

The antagonistic nature of these two virulence factors can be used to enhance the rate of pathogenicity in a particular cell or tissue of an individual. In the case of coagulase, a protection cover is generated with the help of fibrin that prevents the further action of drugs and does not allow the process of phagocytosis. In streptokinase, the fibrin/clot is dissolved leading to growth and spread of microorganism resulting in the spread of infection to other part of cells.

Hence, these two virulence factors work antagonistically to increase the process of pathogenicity in an individual.

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Different strains of Streptococcus pyogenes have different virulence factors, giving these microbes much versatility. Virulence factors include which of the following? Choose one or more: A.A capsule that, when thick, will help the organism avoid phagocytosis by macrophages B.A cell wall containing lipoteichoic acid, thought to facilitate adherence to pharyngeal epithelial cells C.Enzymes that lyse blood cells (streptolysins) D.The production of several endotoxins called streptococcal pyogenic endotoxins (SPEs)
Discuss the following virulence factors: collagenase, hemolysin, siderophore. For each, explain the molecules involved, the pathogen-host interaction, and name a species and disease associated with each factor.
Which virulence factor description among A-E is false? view Later A) O Adhesins: fimbriae or pili are examples of this B) O Invasins: virulence factor of intracellular pathogens C) O Kinases: breaks apart a blood clot; streptokinase is an example. D) O Hyaluronidases: dissolves connections between cells of a tissue E) O Coagulases: found in certain Staphylococcus pathogens; induces clot formation in the body F) O None of A-E is false; all are true 12 Review Later O Type here to search 13 * 12 * esc 立
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