Anatomy notes

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Oct 30, 2023

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? Week 1- Introduction & Nervous System pt.1 Anatomical position Superior (cranial): toward the head end or upper part of a structure or the body; above o ex: the head is superior to the abdomen Inferior (caudal) : away from the head end or toward the lower part of a structure or the body; below o ex: the navel is inferior to the chin Anterior (ventral) : toward or at the front of the body; in front of o ex: the breastbone is anterior to the spine Posterior (dorsal) : toward the back of the body; behind o ex: the heart is posterior to the breastbone Medial: toward or at the midline of the body; on the inner side of o ex: the heart is medial to the arm Lateral: away from the middle of the body; on the outer side of o ex: the arms are lateral to the chest Proximal : closer to the origin of the body part or the point of attachment of a limb to the body trunk o ex: the elbow is proximal to the wrist Distal: farther from the origin of a body part or the point of attachment of a limb to the body trunk o ex: the knee is distal to the thigh Superficial: toward or at the body surface Deep (internal): away from the body surface; more internal Ipsilateral: on the same side Contralateral: on opposite sides Planes of section through body Sagittal (median): front middle Frontal (coronal): side middle Transverse: dividing upper and lower body Body movements Flexion: decreasing the angle of a joint extension: increasing the angle of a joint Abduction: movement away from the midline Adduction: movement toward the midline Lateral/ medial rotation Division of the nervous system: Central nervous system peripheral nervous system sensory (afferent) division, motor (efferent) division Somatic nervous system Autonomic nervous system Sympathetic division, parasympathetic division What is a spinal nerve? Part of the peripheral nervous system Mixed nerve carrying motor and sensory information between the spinal cord and body
31 pairs of spinal nerves Bony framework: Vertebrae surround spinal cord Spinal nerves exit between the vertebrae at the intervertebral foraman o Foraman between two vertebrae During fetal growth the spinal column grows at a faster rate than the spinal cord Sections of the spine and number of vertebrae in each cervical: 7 thoracic: 12 lumbar: 5 Sacral: 5 coccygeal: 1 Sections of the spinal cord and number of nerves in each cervical: 8 thoracic: 12 lumbar: 5 Sacral: 5 Coccygeal: 1 How far does the spinal cord go about to L1 then it is just nerves Where do nerves exit cervical: EXIT ABOVE VERETBRAE lumbar, thoracic, sacral: exit below Spinal cord to spinal nerve flow spinal cord - dorsal rootlets - dorsal root - spinal nerve - ventral rootlets - ventral root- spinal nerve divides into dorsal ramus and ventral ramus ventral root and rootlets: MOTOR dorsal root and rootlets: SENSORY the motor nerves stop at muscle and then the sensory ones continue onto the skin Dermatomes area of skin innervated by a single spinal nerve Important for diagnosing spinal injuries and shingles (varicella-zoster virus) Motor function: Each terminal branch applies a group of muscles within the upper limb Terminal branch Muscle group Muscle example musculocutaneous Arm flexors Biceps brachii median Forearm and hand flexors Flexor digitorum radialis ulnar Forearm and hand flexors Flexor digitorum ulnaris radial Arm and forearm extensors Triceps brachii axillary shoulder deltoid Brachial plexus
network of nerves that supply the upper limb begins at neck and ends at armpit, terminal branches continue down the length of arm formed by the ventral ramus brachial plexus terminal branches have mixed function (both sensory and motor) multiple spinal levels compose muscles - therefore damage may just cause weakness but not total paralysis, however sensory region would be entirely knocked out Organization of the brachial plexus roots, trunks, divisions, cords, branches o (really thirsty drink cold beer) roots of brachial plexus: C5, C6, C7, C8, T1 trunks of brachial plexus: superior, middle, inferior divisions of brachial plexus: 3 anterior and 3 posterior cords of brachial plexus: lateral, posterior, medial branches of brachial plexus: musculocutaneous, axillary, radial, median, ulnar, musculocutaneous nerve arm flexors - coracobrachialis, biceps brachii, brachialis c5, c6, c7 o median nerve o forearm and hand flexors c5,c6,c7,c8,t1 o ulnar nerve o forearm and hand flexors c8, t1 o radial nerve o forearm and arm extensors triceps o C5, C6, C7, C8, T1 axillary nerve shoulder - deltoid and teres minor o c5 c6 pectoral girdle o scapula (posterior) and clavicle (anterior) Week 2- Shoulder & Arm The shoulder is not a true girdle - scapula do not meet in the back function: attachment of upper limb to skeleton, movement and flexibility in various planes o this extra mobility results in a trade off of weakness and proneness to injury Clavicle 2 ends o sternal end - attaches to manubrium of sternum
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o acromial end - attaches to acromium process of scapula function of clavicle o provides muscle attachment o acts as brace for the scapula and arms o transmits compression force fracture of clavicle o occurs in center o side with the fracture will collapse medially and droop - very easy to see its "braceing" function Scapula located on dorsal rib cage between ribs 2 and 7 3 borders and angles of scapula o superior, medial (next to spinal column) o lateral (ends in glenoid fossa where humerus connects) lateral (glenoid fossa) superior (superior and medial meet) inferior (medial and lateral meet) Other features of scapula subscapular fossa (front) infraspinous fossa supraspinous fossa acromium spine (on posterior) coracoid process Prime mover major action (agonist) antagonist: muscle that opposes action synergist: muscle that assists a prime mover Movements of the scapula Elevation/Depression (shrugging) Retraction/Protraction (punching) Upward rotation/Downward rotation (arms overhead) Muscles of posterior thorax 1. trapezius 2. levator scapulae 3. rhomboids (major and minor) Trapezius origin: medial third of superior nuchal line, nuchal ligament, occipital protuberance, spinal processes C7-T12 insertion: lateral third of clavicle, acromium, spine of scapula action: elevate (superior fibers), retract (medial fibers), rotate scapula, inferior depress scapula innervation - accessory nerve (CN XI) Levator scapulae origin: transverse processes of vertebrae c1-c4 insertion: top of medial scapula Action: elevate and rotate scapula inferiorly innervation: dorsal scapular (c5) and cervical nerves (c3-c4) Rhomboids origin:
o minor - nuchal ligament and spinous processes c7-T1 o major - spinous processes t2-t5 insertion: medial border of scapula action: retract and rotate scapula, attaches scapula to thoracic wall innervation - dorsal scapular nerve Muscles of anterior thorax: 1. pectoralis minor 2. serratus anterior 3. subclavius Pectoralis minor origin: ribs 3-5 insertion: coracoid process of scapula action: lifts scapula anteriorly and inferiorly innervation: medial pectoral nerve Serratus anterior Origin: fleshy slips from upper ribs Insertion: bottom part of medial margin of the scapula innervation: long thoracic nerve Actions: protracts and stabilizes scapula, assists in upward rotation Subclavius stabilizes and depresses pectoral girdle Rotator cuf 4 muscles that originate on scapula and CROSS SHOULDER JOINT to insert on humerus 1. subscapularis 2. supraspinatus 3. infraspinatus 4. teres minor Subscapularis this guys on the front Insertion: LESSER tubercle Action: medial (internal rotation) Innervation: subscapular nerve Supraspinatus Action: abducts arm and prevents downward dislocation Innervation: suprascapular nerve Infraspinatus Action: lateral rotation Innervation: suprascapular nerve Teres minor Action: lateral rotation (outward) Innervation: axillary nerve which muscles of rotator cuf rotate? 1. Subscapularis 2. Infraspinatus 3. teres minor which muscle of rotator cuf abducts? 1. supraspinatus Humerus
proximal end - head attaches to glenoid cavity distal end - meets radius and ulna and forms elbow joint humerus epicondyles o 2: lateral and medial o these are attachment sites for muscles: condyles of humerus trochlea - attaches to ulna capitulum - attaches to radius other bony features of humerus o radial grove o deltoid tuberosity o greater and lesser tubercule o intertubercule sulcus o radial fossa and coronoid foss - anterior o olecranon fossa - posterior side glenohumeral joint shoulder joint - most common site of dislocation o most are on the anterior plane radius is always thumb side Anterior muscles of the arm FLEXION: 1. pectoralis major 2. Coracobrachialis 3. posterior muscles of the arm EXTENSION: 1. teres major 2. latissimus dorsi pectoralis major Origin: clavicular head to medial part of clavicle, Sternocostal head: anterior surface of the sternum, the superior six costal cartilages, and the aponeurosis of the external oblique muscle insertion: Lateral lip of the intertubercular groove of humerus Actions: flexion, adduction, medial rotation of shoulder innervation: lateral and medial pectoral nerves Coracobrachialis Origin Coracoid process of scapula Insertion: middle third of Medial humerus innervation: Musculocutaneous nerve action: flexes and adducts the arm teres major origin: dorsal surface of inferior angle of scapula insertion: intertubercular groove of humerus action: extends, adducts and medially rotates arm innervation: lower scapular nerve latissimus dorsi Origin: Spinous processes of vertebrae T7-L5, thoracolumbar fascia, iliac crest, inferior 3 or 4 ribs Insertion: intertubercular groove of the humerus Nerve: Thoracodorsal nerve Actions: Adducts, extends and medially rotates shoulder
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Deltoid composed of 3 sets of fibers: anterior, medial and posterior origin: lateral 1/3 of clavicle, acromium and spine of scapula insertion: deltoid tuberocity action: o anterior - flex and medially rotate o medial: abducts o posterior -extends and laterally rotates innervation: axillary Upper crossed syndrome TIGHT: Upper Traps, levator scap, TIGHT: pectorals WEAK: deep neck flexors, lower traps and serratus anterior an example of needing balance in the body: strengthen your lower tramps, rhomboids and stretch the tight muscles Postural Changes: Forward Head Posture o increased cervical lordosis o increased thoracic kyphosis o fwd & protracted shoulders o rotation and abduction or winging of scapulae o compartments of the limbs o dense fibrous connective tissue divide the muscles of the limbs into compartments each compartment muscles are innervated by the same nerve and have similar actions opposite compartments = agonists/antagonists for each other compartment syndrome Increased pressure within a compartment = insufficient blood supply to the tissue within that space fascia does not allow for expansion can lead to loss of myoneural function and necrosis amputation may be necessary occurs in both upper and lower limbs anterior and posterior compartments of the arm cross the elbow and regulate movement o pronation/supination o flexion/extension Anterior Compartment of the arm 1. biceps brachii 2. Brachialis 3. coracobrachialis the FLEXORS biceps brachii Origin o Short head: coracoid process of the scapula. o Long head: supraglenoid tubercle Insertion: Radial tuberosity and bicipital aponeurosis of forearm innervation: Musculocutaneous nerve
Action: Flexes elbow, supinates forearm Brachialis origin: distal portion of anterior humerus insertion: coronoid process and tuberocity of ulna action: flexor of forearm innervation: musculocutaneous (and radial) Posterior compartment of arm EXTENSORS 1. triceps brachii 2. Anconeus triceps brachii Origin: o Long head- infraglenoid tubercle of scapula o lateral head- posterior humerus (below grove) o medial head- posterior humerus (above grove) Insertion: proximal end of Olecranon of ulna and forearm fascia Action: Powerful forearm extensor, long head steadys abducted humerus head innervation: radial nerve ? Week 3- Forearm (extenders) & Hand carpal bones some lovers try positions they cant handle 1. scaphoid 2. Lunate 3. Triquetrum 4. Pisiform 5. Trapezium 6. trapezoid 7. Capitate 8. hamate bones of the hand carpals, metacarpals, proximal, intermediate and distal phalanges thumb has no intermediate phalange
superficial muscles of anterior forearm 1. pronator teres 2. flexor carpi radialis 3. palmaris longus 4. flexor carpi ulnaris Pronator teres Origin: medial epicondyle of humerus and coronoid process of ulna Insertion: Middle of the lateral surface of radius Innervation: median nerve Action: pronation of forearm, flexes elbow palmaris longus Origin: medial epicondyle of humerus Insertion: palmar aponeurosis and distal 1/2 of flexor retinaculum Innervation: median nerve Action: weak wrist flexor and tightens palmar aponeuerosis little functional value - used as a donor tendon o some people do not even have this flexor carpi radialis Origin: medial epicondyle of humerus (common flexor tendon) Insertion: Bases of second metacarpals Innervation: Median nerve Action: Flexion and abduction at wrist flexor carpi ulnaris Origin: o humeral head: Medial epicondyle o ulnar head: olecranon and post. border of ulna Insertion; Pisiform, hook of the hamate, base of the fifth metacarpal bone Innervation: ulnar nerve Action: Flexion and adduction of wrist Middle muscle of forearm (anterior) flexor digitorum superficialis Origin o humeral head: medial epicondyle, coronoid process of ulna, ulnar collateral ligament o radial head:top 1/2 of the front of the radius Insertion: middle of your 2-5 digits Innervation: median nerve Action: flexor of middle phalanges at proximal interphalangeal joints (not thumb) and proximal phalanges at metacarpalphalangeal joints deep muscle of anterior forearm 1. flexor digitorum profundus 2. flexor pollicis longus (thumb) 3. pronator quadrus flexor digitorum profundus Origin: upper 3/4 of the anterior and medial surfaces of the body of the ulna, interosseous membrane Insertion: base of the distal phalanges of digits 2-5 Innervation: o digits 4 and 5 - ulnar nerve
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o digits 2 and 3 - median nerve Action: assists with flexion of hand and flexes distal phalanges at interphalangeal joints (2-5) flexor pollicis longus Origin: anterior of radius and the adjacent interosseus membrane. Insertion: The base of the distal phalanx of the thumb Innervation: Anterior interosseous nerve (from median nerve) Action: Flexion of the thumb. pronator quadratus Origin - distal 1/4 of front of ulna Insertion - distal 1/4 of front of radius Innervation: anterior interosseous nerve (from median nerve) Action: pronates the forearm, fibres bind the radius and ulna together Brachioradialis Origin: proximal 2/3 of lateral supracondylar ridge of humerus Insertion: lateral surface of bottom of radius Action: forearm flexion innervation: radial nerve o lateral 1/2 is innervated by the median nerve o technically a posterior compartment muscle hangboard training deep holes = superficial muscles shallow - recruit deeper muscles golf elbow MEDIAL epicondylitis , Wrist FLEXOR injury, repetitive injury carpal tunnel syndrome compression of the median nerve as it passes between the ligament and the bones and tendons of the wrist cutaneous innervation of hand 1. Radial nerve- most of the back of the hand, including the thumb 2. Medial nerve- most of the palm of the hand, including the thumb 3. Ulnar nerve- the pinky and half the ring finger, both sides Hand of Benediction damage to MEDIAN nerve resulting in loss of flexion of digits 2 and 3 wrist drop radial nerve injury common with fracture of humerus claw hand ulnar nerve injury no tight grip superficial muscles of posterior forearm 1. extensor carpi radialis longus 2. extensor carpi radialis brevis 3. extensor digitorum (digiti minimi) 4. extensor carpi ulnaris extensor carpi radialis longus Origin: lateral supracondylar ridge of humerus Insertion: base of 2nd metacarpal Innervation: radial nerve Action: extensor at the wrist joint, abducts the hand at the wrist
extensor carpi radialis brevis Origin: Lateral epicondyle of humerus Insertion: Base of third metacarpal bone Action: Extension and abduction at wrist innervation: deep branch of radial nerve extensor digitorum origin: lateral epicondyle of humerus insertion: extensor expansions of digits 2-5 action: extends digits 2-5 at metacarpophalangeal joints and extends hand at the wrist joint innervation:: posterior interosseaus nevre (from radial nerve) extensor carpi ulnaris Origin: Lateral epicondyle of the humerus Insertion: base of 5th metacarpal Action: Extends and adducts the hand at wrist joint innervation: posterior interosseus nerve (radial nerve) Deep muscles of the posterior forearm 1. Supinator 2. abductor pollicis longus 3. extensor pollicis brevis 4. extensor pollicis longus 5. extensor indicis supinator Origin: Lateral epicondyle of humerus, supinator fossa, radial ligaments, crest of ulna Insertion: Radius Action: Supinates forearm innervation: deep branch of radial nerve abductor pollicis longus Origin: Posterior surface of middle of radius, ulna, and interosseous membrane Insertion: Base of 1st metacarpal bone Action: Abduction and extension of thumb at CMC and radial deviation of wrist Innervation: posterior interosseus nerve (Radial Nerve) extensor pollicis longus Origin: Posterior surface of middle of ulna and interosseous membrane Insertion: Base of distal phalanx of thumb Action: Extension of thumb at CMC and IP joints Innervation: posterior interosseus nerve - Radial Nerve extensor pollicis brevis Origin: Posterior surface of middle of radius and interosseous membrane Insertion: Base of 1st proximal phalanx Action: Extension of proximal phalanx of thumb at CMC joint Innervation: Radial Nerve (posterior interosseus nerve) Extensor Indicis Origin: Posterior surface of ulna + interosseus membrane Insertion: Extensor expansion of 2nd digit (index finger( Action: Extension of index finger + helps extend hand Innervation: posterior interosseus nerve - Radial Nerve
anatomical snuf box contains the radial artery, cutaneous branch of radial nerve, scaphoid bone tennis elbow Lateral epicondylitis Common extensor origin opposable thumbs only digit that can "turn back" allows us to have a power grip and precision grip fine motor movements 1. extrinsic muscles of thumb 2. Flexor pollicis longus 3. Extensor pollicis longus 4. Extensor pollicis brevis 5. Abductor pollicis longus intrinsic muscles of the thumb 1. adductor pollicis 2. flexor pollicis brevis 3. opponens pollicis 4. abductor pollicis brevis 3 groups of intrinsic muscles of the hand thenar (4) hypothenar (3) palmar lumbricals (4) interosseus (3 PAD, 4 DAB) 1. thenar muscles 2. abductor pollicis brevis 3. flexor pollicis brevis 4. opponens pollicis 5. adductor pollicis abductor pollicis brevis Origin: flexor retinaculum, the scaphoid and trapezium Insertion: base of proximal phalanx of thumb Innervation: Recurrent branch of the median nerve Action: Abduction of the thumb and helps with opposition flexor pollicis brevis Origin: flexor retinaculum, the scaphoid and trapezium Insertion: base of proximal phalanx of thumb Innervation: Recurrent branch of the median nerve Action: Flexes the thumb Opponens Pollicis Origin: flexor retinaculum, the scaphoid and trapezium Insertion: lateral side of 1st metacarpal Innervation: Recurrent branch of the median nerve action: opposition of thumb adductor pollicis Origin o Transverse head: anterior body of the 3rd metacarpal
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o Oblique head: bases of the second and the third metacarpals and the capitate bones Insertion: medial side of the base of the proximal phalanx of the thumb innervation: deep branch of the ulnar nerve Action: adducts the thumb hypothenar muscles 1. abductor digiti minimi 2. flexor digiti minimi brevis 3. opponens digiti minimi abductor digiti minimi Origin: (pisiform) Insertion: Proximal phalanx of little finger action: abducts pinky innervation: ulnar nerve Flexor digiti minimi brevis Origin: Flexor retinaculum and hook of hamate Insertion: Medial side of proximal phalanx of 5th finger Action: Flexion of proximal phalanx of pinky Innervation: Ulnar Nerve Opponenes digiti minimi Origin- Hook of hamate and flexor retinaculum Insertion- medial border of pinky Innervation- Ulnar nerve Main Action- bringing pinky into opposition with thumb palmar muscles 1. Lumbricals 2. Palmar Interossei 3. Dorsal Interossei Palmar Interossei Origin: metacarpals Insertion: proximal phalanx Innervation: Ulnar nerve Action: ADDUCTION Dorsal Interossei Origin: Metacarpals Insertion: Proximal phalanx Innervation: ulnar nerve Action: Abduct finger lumbricals Origin: tendon of flexor digitorum profundus Insertion: extensor expansion on posterior Innervation: o 1, 2, = median o 3,4, = ulnar Action: flex metacarpophalangeal joints, extend interphalangeal joints innervation of the hand 1/2 LOAF = median (4,3 of lumbricals, opponenes pollicis, adductor pollicis brevis, flexor pollicis brevis ) everything else = ulnar
? Week 4- Lower Limb, Thigh & Glute 3 compartments of the thigh anterior - 7 medial - 5 posterior - 3 glute, 6 lateral roatator and 3 hamstring pelvic girdle the hip bones (2), sacrum, and coccyx Connects the lower limbs to the axial skeleton + spine Less range of movement than shoulder and far more stable childhood hip development 3 hip bones (ileum, pubis, and ischium) which later fuse in adulthood Hip bones fuse anteriorly to each other Fuse posteriorly at sacrum + vertebral column Pelvis femur anatomy: protruding part of hip that you feel anterior superior iliac spine if you break a hip where does it ususally occur neck of the femur Joint: the point where two bones come together vary greatly in structure and function: the structure of the joint determines the degree, range and direction of movement 3 types of joints 1. Fibrous 2. Cartilaginous 3. Synovial fibrous joints immovable (synathroses) o connected by fibrous tissue o i.e. tibiofibular joint cartilaginous joints slightly movable (amphiarthroses) hylaine cartilage or fibrocartilage o i.e. intervertebral discs synovial joints freely movable (diarthroses) appendicular skeleton components of synovial joints: articular cartilage (lines the bones) joint cavity w synovial fluid in it articular cavity (outer fibrous + inner synovial membrane) reinforcing ligaments nerves and vessels
3 movements of synovial joints 1. gliding 2. angular (extension, adduction, circumduction) 3. rotation types of synovial joints plane: patella + femur hinge: elbow pivot: radio-ulnar condyloid: wrist saddle: metacarpal of thumb ball and socket : hip ball and socket joint Spherical head of one bone fits into round socket of another Multiaxial joint hip joint A ball and socket synovial joint with more limited movement It has a deeper ball and socket (compared to shoulder) with greater stability, this allows for the transfer of the weight of the upper body to the lower limbs Femur fits into the acetabulum Labrum (cartilage) really anchors the femur into the acetabulum hip ligaments iliofemoral (strongest in the body) pubofemoral, ischiofemoral attach the femur to the pelvis and stabilize ligament of the head of the femur has no functional role lumbar plexus 1. L1-L4 a. from ventral rami b. located within psoas major muscle c. main branches innervate anterior thigh via femoral and obturator nerves 2. L2-L4 (anterior division) a. innervates adductor muscles and cutaneous region of inner thigh b. femoral nerve 3. L2-L4 (posterior division) a. lies deep to inguinal canal b. Innervates: quadriceps and skin of anterior thigh and knee down Muscles of the anterior thigh 1. iliopsoas m. 2. quadriceps (4) 3. sartorius m. 4. tensor fasciae latae quadricep muscles 1. rectus femoris 2. vastus lateralis 3. vastus medialis 4. vastus intermedius 5. Iliopsoas
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a. a compound muscle composed of psoas and iliacus psoas and iliacus Origin: o psoas: transverse processes of T12 - L5 vertebrae o iliacus: iliac fossa and ala of sacrum Insertion: lesser trochanter via iliopsoas tendon Action: thigh and trunk flexion innervation: femoral nerve Sartorius Origin: Anterior superior iliac spine Insertion: medial aspect of knee and medial aspect of tibia Innervation: femoral nerve Action: Flexion, abduction, and lateral rotation of the hip, weak flexion of the knee longest muscle of the body, crosses both hip and knee rectus femoris Origin: anterior inferior iliac spine, superior margin of acetabulum Insertion: patella and tibial tuberosity via patellar tendon Innervation: femoral nerve Action: knee extension; hip flexion vastus lateralis Origin: Greater trochanter, Intertrochanteric line, and Linea aspera of the Femur Insertion: patella and tibial tuberoscity via patellar tendon Innervation: femoral nerve Action: Extends knee vastus medialis Origin: inea aspera, supracondylar line, intertrochanteric line Insertion: patella and tibial tuberoscity via patellar tendon Action: extends knee and stabilizes patella innervation: femoral nerve vastus intermedius Origin: antero/ lateral femur Insertion: patella and tibial tuberoscity via patellar tendon Innervation: femoral nerve Action: Extension of knee joint medial thigh superficial muscles 1. pectinueus 2. adductor longus 3. gracilis Pectineus Origin: pectineal line of pubis insertion: lesser trochanter to linea aspera on posterior femur action: adduct, flex and medially rotates thigh innervation: femoral (sometimes obturator) adductor longus Origin: pubis Insertion: Linea aspera of femur Action: Adduction, flexion, and medial rotation at hip innervation: obturator nerve
gracilis origin: inferior ramus and body of pubis and ischial ramus insertion: medial surface of tibia action: adducts thigh; flexes and medially rotates leg innervation: obturator nerve Deep medial thigh muscles 1. adductor brevis 2. adductor magnus adductor brevis Origin: inferior ramus and body of pubis Insertion: linea aspera Action: adducts and medialy rotates thigh Innervation: obturator nerve adductor magnus Origin: ischial and pubic rami, ischial tuberoscity Insertion: Linea aspera of the femur, supracondylar line, adductor tubercle of femur Action: o anterior: Adducts, medial rotation and flexion o posterior: thigh extension innervation: obturator nerve and sciatic nerve sacral plexus from spinal nerves L4-S4 directly behind the lumbar plexus 1/2 of the branches serve buttocks and lower limb sciatic nerve largest and most important nerve for the lower limb divides into tibial and common fibular nerve common fibular nerve supplies lateral and anterior lower leg tibial nerve posterior lower leg divides from sciatic nerve at palpatile fossa (back of knee) into the tibial nerve sciatica pain tingling and numbness caused by irritation of the nerve routes leading to the sciatic nerve most common causes: herniated disk or narrowing of spinal canal symptoms made worse from prolonged standing/sitting relieved through extension of spinal cord or drugs Muscles of the butt 1. gluteus maximum (superficial) 2. gluteus medius (middle) 3. gluteus minimus (deep) gluteus maximus Origin: dorsal illium, sacrum and coccyx Insertion Gluteal tuberosity of the femur and iliotibial tract Innervation: Inferior gluteal nerve Action: lateral rotation, extension of the thigh, abducts gluteus medius
Origin: between ant. and post. gluteal lines on lateral illium Insertion: greater trochanter of femur Action: abducts and medially rotates thigh, steadies pelvis during walking innervation: superior gluteal nerve gluteus minimus Origin between ant. and post. gluteal lines on external illium Insertion Greater trochanter of the femur Action: abducts and medially rotates thigh, steadies pelvis during walking innervation: superior gluteal nerve superficial hamstring muscles 1. biceps femoris 2. semitendinosus biceps femoris Origin: o long head: ischial tuberosity and linea aspera o short head: femur Insertion: head of the fibula and lateral tibial condyle Innervation: o long head: tibial nerve o short head: common fibular nerve Actions: flexes knee joint, extends thigh, lateral rotation of leg Semitendenosus origin: ischial tuberosity insertion: medial condyle of tibia to lateral condyle (a hook) innervation: tibial branch (sciatic) action: extends thigh, flex knee, medially rotates leg deep muscles of hamstring 1. semimembranosus Semimembranosus Origin: ischial tuberoscity Insertion: upper tibial shaft Action: Flexion of knee, extension of the hip joint, medially rotates leg innervation: tibial branch (sciatic) iliotibial band thickened portion of the fascia lata extends as a tendonous band from the iliac crest to the knee controlled by the tensor fascia lata (when contracted very taut and steadies the thigh) iliotibial band syndrome an overuse injury caused by excessive friction of the lower end of the band against lateral femoral condyle common in runners makes walking and running painful "leg" Refers to the lower limb ONLY composed of tibia and fibula (more fragile) ? Week 5- Knee, Leg, Foot & Nervous System pt.2 tibia and fibula
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tibia with big toe - medial mallolus fibula - lateral malleolus intercondylar iminence tibial tuberoscity anterior crest connected via interosseus membrane components of the foot 1. tarsus 2. Metatarsus 3. phalanges function of the foot support the weight of the body act as a lever to propel the body forward during locomotion tarsus posterior foot comprised of seven bones 1. alcaneus 2. Talus 3. Cuboid 4. Navicular 5. medial lateral and middle cuneiforms ankle joint tibia and fibula articulate directly with the talus talus then transmits the weight to the calcaneus (heel) characteristics of a typical synovial joint articular cartilage articular capsule (fibrous and synovial) synovial fluid articular disc intracapsular and extracapsular ligaments role of the patella a sesamoid found in most tetrapods increases the distance between the quads and the knee joint = increase in moment arm lower limb uses more rotary torque than the elbow knee joint modified hinge (femoro-tibial) plane (patella-femur) bi-condyloids (4 from tibia and femur) lateral and medial meniscus role cartilage that act as a cushion and distribute the weight and support the joint extracapsular knee ligaments lateral and medial collateral ligaments (LCL, MCL) o prevent side to side movement intracapsular ligaments of knee anterior cruciate ligament (ACL) o prevent forward movement of tibia posterior cruciate ligament (PCL) prevents posterior movement of tibia ACL and PCL during knee extension become taut and lock the knee ligaments on the patella
top: tendon of quadriceps femoris muscle bottom: patellar ligament flanked on both sides by the lateral and medial patellar retinaculum posterior ligaments of knee popliteal ligaments: oblique and acruate blow to the side of knee injury can seperate femur and tibia medially = damage to tibial collateral ligament, medial meniscus, and ACL superficial muscles of the lower leg 1. gastrocnemius 2. Plantaris 3. soleus Gastrocnemius Origin: 2 heads from lateral and medial condyles of femur Insertion: calcaneus (achillies tendon) Action: plantar flexion, knee extension innervation: tibial nerve Plantaris: little guy Origin: posterior femur above lateral condyle Insertion: calcaneous tendon Action: Plantar flexes foot and flexes knee Antagonist Tibialis anterior muscle soleus Origin: superior tibia, fibula and interosseus membrane Insertion calcaneous tendon Innervation: tibial nerve Action: plantar flexion (MAIN GUY) deep lower leg muscles 1. popliteus 2. flexor digitorum longus (FDL) 3. flexor halllocis longus (FHL) 4. tibialis posterior Popliteus Origin: lateral condyle of femur and lateral meniscus Insertion: proximal tibia Innervation: Tibial nerve Action: flexes and medially rotates lef to unlock from full extension flexor digitorum longus Origin: Posterior tibia Insertion: behind medial malleolus into Distal phalanges of toes 2-5 Action: Flex toes; plantar flexes and inverts foot, grips the ground innervation: tibial nerve flexor hallucis longus origin: middle fibula and interosseus membrane insertion: distal phalanx of big toe action: flexes big toe, plantar flexion, inverts food, "push off" during walking innervation: tibial nerve tibialis posterior Origin: Tibia and fibula
Insertion: behind medial malleolus and under arch of foot to metatarsals 2-4 Innervation: Tibial nerve Action: inversion of the foot (MAIN) plantar flexion organization around medial malleolus- TOM dick and harry lateral components of leg 1. fibularis longus 2. fibularis brevis fibularis longus origin: lateral fibula insertion: under the foot to medial cuneiform and 1st metatarsal action: plantar flexes and everts foot innervation: superficial fibular nerve fibularis brevis Origin: fibula Insertion: behind lateral malleolus to proximal end of 5th metatarsal action: eversion and plantar flexion innervation: superficial fibular nerve anterior compartment of leg 1. tibialis anterior 2. extensor hallucis longus 3. extensor digitorum longus tibialis anterior Origin: lateral condyle and upper tibia, interosseus membrane Insertion: medial cuneiform and 1st metatarsal Action: dorsiflexes and inverts foot innervation: deep fibular extensor digitorum longus Origin: lateral condyle of tibia, top of fibula and interosseus membrane Insertion: middle and distal phalanges of toes 2-5 Innervation: deep fibular nerve Action: main toe extendor and dorsiflexion of foot extensor hallucis longus Origin: fibula and the interosseous membrane Insertion: distal phalanx of the big toe Innervation: deep fibular nerve Action: Extends the big toe, dorsiflexion of foot ganglia clusters of cell bodies in the PNS somatic motor system one motor neuron Voluntary receptors (skeletal muscle) autonomic nervous system two motor neurons involuntary effectors: smooth and cardiac muscle, glandular tissue sympathetic NS (origin, neurotransmitters, ganglia and neuron description) fight or flight origin: thoracolumnar (T1-L2) - lateral horns of spinal cord short pre-ganglion, long post-ganglion achetylcholine (onto post-g) and norepinephrine (onto effectors) o EXCEPT: sweat glands and peropheral BV get Ach
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ganglia: sympathetic trunk or collateral ganglia parasympathetic nervous system (origin, neurotransmitters, ganglia and neuron description) rest and digest origin: craniosacral o brainstem nuclei and sacral S2-S4 long pre-ganglion, short post ganglion achetylcholine ganglia: intramural (within the walls of the organ) which organs get no PSYM input skin and adrenal glands actions of SYM increased HR and BP dilated pupils decreased digestion bronchiole dilation BV dilation actions of PSYM decreased HR and BP increased digestion pupil constriction bronchiole constriction pathway of sympathetic trunk lateral horns of spinal cord via ventral root mixed spinal nerve white rami communicans (myelinated) sympathetic chain 3 possible pathways: -synapse at that level -travel up or down then synapse - travel through chain, exit via splanchic nerves (internal organs) and synapse at collateral ganglia exit via grey rami communicans ventral ramus sympathetic pathway to periphery short pre-ganglion synapse with adrenal glands (Ach)
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stimulate chromaffin cells release of NE onto blood vessels a systemic sympathetic response to effectors sympathetic trunk paravertebral chain paired extends down the length of vertebral column collateral ganglia pre-vertebral (anterior to vertebral column, usually with BV) unpaired exists in abdomen PSYM pathway of head (cranial nerves) ciliary ganglion - smooth muscle of eye pterygopalatine ganglion - nasal mucosa and lacrimal glands Week 6- Heart, Coronary & Pulmonary System superior left heart o 2nd costal cartilage, lateral to sternum superior right of heart o 3rd costal cartilage at sternum inferior right of heart o 6th costal cartilage, lateral to sternum inferior left of heart o 5th intercostal space at midclavicular line Main structures of the heart Superior and inferior vena cava, RA, RV, Pulmonary trunk, LA, LV, Layers of pericardium external: fibrous internal: smooth serous parietal serous visceral serous (aka epicardium) external fibrous layer dense irregular connective tissue stabilizes heart prevents overfilling of blood connects to the pericardial sac superiorly (via roots of great vessels connects to diaphragm inferiorly smooth serous layer parietal serous: lines external fibrous layer visceral serious (epicardium)
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2 layers are separated by pericardial cavity where are the parietal and visceral layers continuous? At the root of the great vessels Where is the apex of the heart Bottom of LV Features of the right atrium Crista Terminalis: separate rough and smooth muscles Pecinate Muscles: rough wall 3 Openings: SVC, IVC, Coronary sinus Fossa ovalis: remnant of foramen ovale Right Auricle Features of right ventricle Interventricular septum Tricuspid valve Papillary muscles Chordae tendinae Pulmonary semilunar valve - 3 semilunar cusps Trabeculae Carnae: roughened projections from walls Left atrium and ventricle features Opening of pulmonary veins Mitral valve leaflet (bicuspid) Chorade tenidnae Papillary Muscle Interventricular septum Purpose of valves in the heart prevent backflow of blood prevents overdilation of valve opening point of attachment of cardiac muscle block electrical impulses from atria to ventricles 4 valves in the heart 2 atrioventricular valves 2 semilunar valves Respiratory system: organ system that carries out gas exchange - supply body with oxygen and carbon dioxide. In order to do this, respiration needs to occur 1. Pulmonary ventilation (breathing) - moving air in and out of the lungs 2. External respiration - gas exchange between blood and air. Oxygen diffuses into blood, carbon dioxide diffuses into the air 3. Transport of gases - the gases must move from lungs to cells of the body (accomplished by the circulatory system) 4. Internal respiration - gas exchange between blood and tissue cells Because the respiratory system moves air in and out of the body, it is also involved in the sense of smell and speech. Upper respiratory tract: nose, nasal cavity, paranasal sinuses, pharynx and larynx Lower respiratory tract: trachea, bronchi (and their branches), lungs, alveoli Conducting zone - carry air to the sites of gas exchange. Filter, humidify and warm incoming air. Respiratory zone - site of gas exchange in the lungs. ? Week 7- Respiratory System 1
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The Nose and Paranasal Sinuses Functions of the nose: Provides an airway for respiration Moistens and warms incoming air Filters incoming air Mucus traps bacteria and particulates Serves as a resonating chamber for speech (think about nasally voices) Houses olfactory receptors The nose is divided into the external nose and the internal nasal cavity; entrance - naris (nostrils), Exit - chonae Surface Anatomy: frontal belly, root and bridge of nose, ala, apex of nose, naris, and philtrum . Skeletal Framework: frontal, nasal, palatine, maxilla, ethmoid and vomer bones; septal, nasal, minor and major alar cartilage . The nasal cavity is divided into two halves with the nasal septum (ethmoid and vomer and septal cartilage) in the middle (formed by the perpendicular plate of the ethmoid bone, the vomer and a septal cartilage). The nasal septum has lots of blood vessels which all come together at Kiesselbach’s area - a typical location of nosebleeds (epistaxis) The lateral wall is made of the nasal, maxilla, palatine and sphenoid bones Chonchae force air through smaller channels and increase surface area through which air contacts respiratory epithelium (mucus). There is the inferior nasal concha , and the ethmoid bone (which is comprised of the superior nasal concha and middle nasal concha Superior nasal cavity is lined with the olfactory epithelium. This is the only area for smell in the cavity. The rest of the nasal cavity is lined with respiratory epithelium (mucus-producing) Underneath each concha there is a superior, middle and inferior meatus that structures can connect to. The nasal cavity connects to the paranasal sinuses, the eyes (nasolacrimal ducts), the oral cavity (pharynx), and the ears (auditory / Eustachian tube). The sinuses are air-filled cavities in the bones. Infection and inflammation of the nasal cavity (rhinitis) and the paranasal sinuses (sinusitis) causes swelling and buildup of mucus. The respiratory mucosa lines the nasal cavity and paranasal sinuses. Its epithelium is covered with a sheet of mucus that filters dust particles and moistens inhaled air. Its lamina propria contains glands that contribute to the mucus sheet and blood vessels that warm the air. 22.1b: The Pharynx The pharynx starts at the posterior of the nasal cavity and extends to the esophagus. It is divided into three segments; Nasopharynx (superior border - sphenoid, inferior border - soft palate) Oropharynx (superior border - soft palate, inferior border - epiglottis) Laryngopharynx (superior border - epiglottis, inferior border - inferior end of cricoid cartilage) 22.1c: The Larynx Forms the upper windpipe. Responsible for keeping food out of the respiratory tract, is an air passageway and acts as the voice box. Key features of the larynx are the
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laryngeal cartilages. Form a skeleton that alters the length and tightness of the vocal cords. Four main cartilages 1. Epiglottis : folds over larynx during swallowing to prevent food from entering the respiratory system. 2. Thyroid : large in the front and side but doesn't go all the way around (forms adam’s apple). The groove above Adam's apple is the superior thyroid notch. Posteriorly there are extensions called horns. Articulates with the cricoid cartilage inferiorly. 3. Cricoid : only cartilage that goes completely around the windpipe. Ring is anterior, the signet is posterior. Connects with thyroid cartilage via cricothyroid ligament. Articulates with thyroid and arytenoid cartilages 4. Arytenoids : pyramid-shaped cartilages on top of cricoid that attach to vocal cords. Rest behind thyroid cartilage and on top of cricoid cartilage. Many muscles attach here that allow movement of the vocal cords. Vestibular Ligaments - Known as false vocal cords. They are more lateral so air typically misses them. - Attach to arytenoid cartilage - Help epiglottis close off larynx during swallowing Vocal Ligaments - True vocal cords - Attach to vocal process of arytenoid cartilages to back wall of thyroid cartilage - Sound is made when air passes over vocal folds. Movement of vocal folds - Speech volume and pitched is completed by regulating the space and thickness of vocal ligaments 22.1d: The Trachea - 16-20 C-shaped rings of hyaline cartilage. - The open posterior parts of the cartilage rings (in front of esophagus), contain the trachealis muscle and soft connective tissue. - The carina (a ridge on the internal aspect of the last tracheal cartilage) marks the point where the trachea branches into the two main (primary) bronchi. Mucosa lines the carina. - Typical histology with adventitia instead of serosa. 22.1e: The Bronchial Tree The two main bronchi are branches of the trachea in the mediastinum. The right main bronchus is wider, shorter and more vertical than the left (inhaled objects are more likely to lodge here. Trachea Primary (main) bronchi Secondary (lobar) bronchi [superior, middle (R only), and inferior] Tertiary (segmental) bronchi [each lung has ~10 that supplies a bronchopulmonary segment. We can resect a segment w/o affecting other segments] ~conducting bronchioles~ terminal bronchioles Respiratory bronchioles Alveoli 22.1f: The Lungs and Pleurae Pyramid-shaped: Apex (rounded superior tip) and Base (concave inferior
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surface) 3 Surfaces: Costal, diaphragmatic, mediastinal 3 Borders: Anterior, posterior, inferior Right (larger): 3 lobes (superior, middle, inferior); oblique and horizontal fissure Left (smaller): 2 lobes (superior and inferior); has cardiac notch; oblique fissure Hilum : entrance and exit of vessels (arteries more superior than veins) and nerves; where parietal (adjacent to abdominal walls) and visceral (covering lungs) pleura meet. Pleurae : fluid-filled (serous) sacs that surround each lung. Pleural Cavity : space between the two pleura; filled with pleural fluid that allows lungs to glide. Pressure in the cavity is always lower than atm pressure. Pneumothorax (collapsed lung): If the pleural cavities are punctured, air and liquid easily enter the pleura because of its low pressure. Causes a pressure increase, leads to the lung collapsing Emboli: The capillaries are so small that they are prone to clots from insoluble material in blood 22.2a: The Mechanism of Ventilation Breathing or pulmonary ventilation consists of two phases: inspiration (inhalation) and expiration (exhalation) External Respiration : gases move from high to low pressure. Type 1 alveolar cells form the alveolar wall. Type 2 alveolar cells produce surfactant. Macrophages protect from infection and dust. Breathing Mechanics: Air moves in and out of the lungs based on the relative pressure compared to atmospheric pressure (low pressure in lungs = inspiration; high pressure in lungs = expiration). Pressure in lungs is controlled by altering the volume of the thoracic cavity (contracting the diaphragm and extra help from other breathing muscles help this to occur). The diaphragm is the principle breathing muscle. Its peripheral muscle fibers attach to the sternum, ribs and vertebrae. Contraction of the diaphragm (flattening of the parachute) increases the volume of the thoracic cavity (inspiration). Relaxation of the diaphragm (resumes parachute shape) decreases the volume of the thoracic cavity (expiration). 22.2b: Neural Control of Ventilation - Neurons from the medullary respiratory center in the medulla oblongata stimulate the phrenic nerve (to diaphragm) and intercostal nerves (to intercostal muscles) - Chemoreceptors respond to changes in blood and can send signals to help blood gasses return to normal levels. Information is sent via the vagus nerve and glossopharyngeal nerve. - Respiratory muscles are under voluntary control but the respiratory centre sets a basic respiratory rhythm Autonomic Control of the Airways: Smooth muscle surrounding the bronchioles controls how much air flows into the alveoli. Parasympathetic: smooth muscle contraction (bronchial constriction, mucus secretion) Sympathetic: smooth muscle relaxation (bronchial dilation) Asthma
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- Allergic inflammatory response to irritants in the air, stress, etc. Symptoms include coughing, wheezing and shortness of breath. Use bronchodilators and glucocorticoids to treat. COPD - Category of disorders in which the flow of air in or out of the lungs is difficult or obstructed. Mostly refers to chronic bronchitis or emphysema (usually occurring together) - Bronchitis: irritants lead to prolonged secretions of mucosa, inflammation and fibrosis of the mucosa. Obstructs airways and houses bacteria and viruses. Results in low blood oxygenation which results in cyanosis and other signs of heart failure (including edema) - Emphysema: permanent enlargement of the alveoli. Chronic inflammation leads to fibrosis and the lungs become less elastic. Breathing becomes difficult and exhausting. Typically creates a barrel chest. Treated with bronchodilators and anti-inflammatory drugs ? Week 8+9- Digestive System 23.1b: The Peritoneal Cavity and Peritoneum The digestive organs all develop surrounded by the peritoneum and the peritoneal cavity (allows organs to glide over one another). Peritonitis : inflammation and infection of the peritoneum. Can arise from a piercing wound to the abdomen, from a perforating ulcer that leaks stomach juices into the peritoneal cavity. Mesenteries : A mesentery is a double layer of peritoneum (a sheet of two serous membranes fused together) that extends from the body wall to the digestive organs. Mesenteries hold organs in place, store fat (limit spread of infections), and provide a route for circulatory vessels. 23.1c: Digestive processes 1. Ingestion is the taking of food into the mouth 2. Propulsion is the movement of food through the alimentary canal. It includes swallowing, which is initiated voluntarily and peristalsis, an involuntary process. Peristalsis involves alternate waves of contraction and relaxation of musculature in the organ walls. Its net effect is to squeeze food from one organ to the next but some mixing occurs too. 3. Mechanical breakdown physically prepares food for digestion by enzymes by breaking it down into smaller pieces. Mechanical processes include chewing, the churning of food in the stomach, and segmentation. 4. Digestion is a series of steps in which food molecules are broken into their chemical building blocks. Glands in the GI tract and accessory organs produce enzymes and other substances and secrete them into the lumen of the alimentary canal. 5. Absorption is the movement of digested products from the lumen of the alimentary canal into the blood and lymph located in the wall of the canal. 6. Defecation is the elimination of indigestible substances from the body as feces. 23.2b: Smooth Muscle Most smooth muscle is found in the walls of visceral organs. There are six major locations: the iris, and the walls of the circulatory vessels, respiratory tubes,
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digestive tubes, urinary organs, and reproductive organs. Most often there are two sheets, a longitudinal layer and a circular layer. Smooth muscle is innervated by the autonomic (automatic) nervous system. Does not always require a nervous signal, can be stimulated by stretching or hormones. 23.2c: The Mouth and Associated Organs The mouth is a mucosa-lined cavity whose boundaries are; Anterior Border: Lips Superior Border: Hard Palate and Soft Palate Posterior Border: Fauces Lateral Borders: Cheeks Inferior Border: Tongue Its opening is the oral orifice. Posteriorly, the mouth borders the oropharynx. The mouth is divided into the oral vestibule (slit between the teeth and cheeks/lips) and the oral cavity proper (the region internal to the teeth) The labial frenulum is a median fold that connects the internal aspect of each lip to the gum The Palate The palate has two distinct parts: the hard palate and the soft palate. The soft palate is a mobile flap that rises to close off the nasopharynx during swallowing. Dipping inferiorly from the free edge of the soft palate is the uvula (don’t really know what uvula does). The soft palate is anchored to the tongue by the palatoglossal arches and to the wall of the oropharynx by the palatopharyngeal arches The Tongue Motor Innervation of the Tongue The hypoglossal nerve innervates most intrinsic and extrinsic muscles of the tongue. The intrinsic muscles change the shape of the tongue, whereas the extrinsic muscles extend the tongue from bones of the skull and the hyoid bone. These intrinsic muscles allow the tongue to protrude, retract, etc. There are four pairs of extrinsic muscles: Styloglossus (tongue to styloid) Genioglossus (tongue to chin) Hyoglossus (tongue to hyoid) Palatoglossus (tongue to palatoglossal arch) Sensory Innervation of the Tongue - Facial nerve (for taste) - Trigeminal nerve (for sensation) - Glossopharyngeal nerve (sensation and taste for posterior 1 3 of the tongue (lingual tonsil area)) The lingual frenulum is a fold on the under surface of the tongue that secures the tongue to the floor of the mouth. The dorsal surface of the tongue is covered with three major types of projections of the mucosa The foliate are like serrated edges on the side of your tongue. The filiform papillae roughen the tongue and allow it to grasp and manipulate food (can’t really see) The fungiform papillae are scattered widely. Taste buds occur on the tops of these papillae. 10-12 vallate papillae line up in a v-shaped row bordering the posterior third of the tongue (terminal sulcus). Taste buds are on the sides of these papillae.
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The posterior third of the tongue, which lies in the oropharynx, is covered with bumpy lingual tonsil . The Salivary Glands Produce saliva (mixture of water, ions, mucus and enzymes) that has many functions such as moistening the mouth, dissolving food chemicals, wets food and binds the food together. Its enzymes begin the digestion of carbohydrates and fats. Contains bicarbonate buffer that neutralizes the acids in the mouth. Minor (intrinsic) salivary glands within the mucosa of the tongue, palates, lips and cheeks keep the mouth moist at all times. Major (extrinsic) salivary glands (lie external to the mouth but connect via ducts) secrete saliva only during eating or anticipation of eating. These glands are the parotid, submandibular and sublingual glands . The largest major gland is the parotid (par = near; otid = the ear). The parotid duct penetrates the muscle of the cheek and opens into the mouth lateral to the second upper molar. Secretion is stimulated by the glossopharyngeal nerve . The submandibular gland lies just anterior to the mandible bone. Its ducts open in the floor of the mouth just lateral to the tongue’s lingual frenulum. The sublingual gland lies in the floor of the oral cavity, inferior to the tongue. Its 10-12 ducts open into the mouth directly superior to the gland. Both the sublingual and submandibular glands are innervated by the facial nerve . Sialography : radiographic examination of the salivary glands. Evaluate the functional integrity of the salivary glands. 23.2d: The Pharynx The pharynx is a muscular tube that runs from the back of the nasal to the esophagus, carrying air and food to respiratory and digestive structures. It is divided into 3 portions: nasopharynx, oropharynx and laryngopharynx . Swallowed food passes posteriorly into the oropharynx and then the laryngopharynx. The muscles of the neck and pharynx contract in sequence to complete the swallowing process. 1. The suprahyoid muscles lift the larynx superiorly and anteriorly to position it beneath the protective flap of the epiglottis, thus closing the airway so food is not inhaled into the lungs. 2. The three pharyngeal constrictor muscles - superior, middle and inferior - encircle the pharynx and partially overlap each other. They squeeze the bolus into the esophagus. The pharyngeal muscles are skeletal muscles innervated by somatic (voluntary) neurons carried in the vagus nerve . 3. The infrahyoid muscles pull the hyoid bone and larynx inferiorly returning them to their original position. Tonsils: 4 sets. Accumulation of lymphoid nodules. First line of defense. Palatine tonsils : most often removed Lingual tonsils : base of tongue Tubal tonsils : located around Eustachian tube Pharyngeal tonsils : aka adenoids Swallowing: 1. Oral Phase (mouth to oropharynx; forms food bolus; consists of chewing and mastication) Voluntary. Tongue elevates and pushes food bolus again the hard palate and
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backward to the oropharynx. Intrinsic and extrinsic muscles of the tongue and cheek muscles push the bolus backwards until it reaches the palatoglossal and palatopharyngeal arches. 2. Pharyngeal Stage (oropharynx to esophagus; nasal cavity and larynx closed off; contraction of the pharynx) Involuntary. Blocks 3 cavities and contracts the pharynx to force bolus into the esophagus. The oral cavity is blocked by tongue elevation The nasal cavity is blocked by elevation of the soft palate. Three muscles; tensor veli palatini (tenses soft palate), levator veli palatini (elevates soft palate), palatopharyngeus (tenses soft palate - helps close off nasopharynx) The larynx is blocked by elevation of the larynx which causes the epiglottis to fold over the laryngeal inlet. The suprahyoid muscles lift the larynx superiorly and anteriorly ( mylohyoid, stylohyoid, digastric muscles ) 3. Esophageal Stage (esophagus to stomach; completes swallowing process) Involuntary. Contraction of skeletal muscle in the upper part of the esophagus. Peristalsis. As swallowing ends, the infrahyoid muscles pull the hyoid bone and larynx inferiorly and return them to their original position. 4. Contraction of the Pharynx Pharyngeal constrictor muscles encircle the pharynx and partially overlap each other. They contract sequentially. Superior pharyngeal constrictor Middle Pharyngeal constrictor Inferior pharyngeal constrictor. Peristalsis : Adjacent segments of GI tract contract and relax. Occurs in the esophagus, stomach, small and large intestine. Segmentation : Non adjacent segments of GI tract alternately contract and relax, moving food forward then backward. Occurs in the small intestine. Histology: The walls of the GI tract have the same four tissue layers 1. Mucosa : directly surrounding lumen. Absorption, secretions, etc. Consists of three sublayers. 1. Lining epithelium - highly differentiated along regions of the GI tract. Responsible for absorbing nutrients and secreting mucus. 2. Lamina propria - connective tissue whose capillaries nourish the lining epithelium and absorb digested nutrients. 3. Muscularis mucosae - layer of smooth muscle that produces local movements of the mucosa 2. Submucosa : blood and nervous supply. The many elastic fibers allow the alimentary canal to return to its original shape after food material passes through it. Where feelings of distress come from. 3. Muscularis Externa : facilitate peristalsis and segmentation. Consists of two layers. 1. Inner circular layer - fibers orient around the circumference of the canal. Squeezes the gut tube. In some places the layer thickens and forms sphincters (cardiac and pyloric, for example) 2. Outer longitudinal layer - fibers orient along the length of the canal. Shortens the gut tube. Great for peristalsis and segmentation.
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4. Serosa : provides slippery surface. It is very thin and as the canal expands and contracts, the slippery surface rescues friction against adjacent structures (AKA visceral peritoneum). Parts of the alimentary canal that are not associated with the peritoneal cavity lack a serosa and have an adventitia as their outer layer. The esophagus has an adventitia that binds it to surrounding structures. Retroperitoneal organs have both a serosa and adventitia, the former on the anterior side facing the peritoneal cavity and the later on the posterior side embedded in the posterior abdominal wall. 23.2e: The Esophagus Starts as a continuation of the pharynx in the midneck, descends through the thorax and passes through the esophageal hiatus in the diaphragm to enter the abdomen. Joins the stomach at the cardial orifice, where a cardiac sphincter acts to close off the lumen and prevent regurgitation. Unlike the mouth and pharynx, the esophageal wall contains all four layers of the alimentary canal: mucosa, submucosa, muscularis externa and adventitia. Note that the most external layer is the adventitia, not serosa. This is because the thoracic segment of the esophagus is not suspended in the peritoneal cavity. Clinical application: Hiatal Hernia In a hiatal hernia, the superior part of the stomach pushes through an enlarged esophageal hiatus into the thorax following a weakening of the diaphragmatic muscle fibers around the hiatus. Because of this the acidic stomach juices are persistently regurgitated, eroding the wall of the esophagus and causing a burning pain. Clinical application: Gastroesophageal Reflux Disease Regurgitation associated with the hiatal hernia is just one form of GERD. Most cases are due to abnormal relaxation or weakness of the esophageal sphincter. Symptoms include heartburn, regurgitation of stomach contents and belching. After continuous exposure to the acidic stomach contents, the lower esophagus develops ulcers. 23.2f: The Stomach Temporary storage tank in which the bolus is churned and turned into a paste (chyme). The stomach also starts the breakdown of proteins (produces pepsin). Most substances are absorbed in the small intestine, but some are absorbed in the stomach, including water, electrolytes and some drugs. Food remains in the stomach for roughly four hours. The stomach has four major regions: Cardia : Encircles the cardial orifice and contains the cardiac sphincter Fundus : Part of the stomach that rises above the cardia. Gas bubbles accumulate here. Body : Majority of the stomach Pyloric Region : Composed of 2 parts: canal and antrum. Contains pyloric sphincter Two curvatures: lesser curvature (sharp and short) and greater curvature (long and soft). The greater and lesser omentum, the mesenteries that connect to the stomach, are named for their attachment to these curvatures. The inner surface of the stomach contains rugae which are numerous longitudinal folds of mucosa which flatten as the stomach fills. Histology: 1. Mucosa: simple columnar epithelium with mucus glands. Dotted with gastric pits that open into tubular gastric glands. In the pyloric and cardiac regions the cells of the
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glands are primarily mucous cells . In the fundus and body regions the gastric glands contain four cell types; mucous cells (secrete mucus and bicarbonate), chief cells (secrete pepsinogen and gastric lipase for fat digestion), parietal cells (produce HCL and intrinsic factor), and enteroendocrine cells (release hormones into capillaries underlying lamina propria) 2. Submucosa: contains blood, lymph and nerves. 3. Muscularis externa: contains 3 layers. The typical inner circular and outer longitudinal but also an innermost oblique. Arterial Supply: From the abdominal aorta and celiac trunk, the left gastric artery, common hepatic artery and splenic artery provide blood to the stomach. 1. Left Gastric: lesser curvature of stomach 2. Common Hepatic Artery 1. Right gastric artery: inferior lesser curvature 2. Right gastroepiploic artery: greater curvature 3. Splenic Artery 1. Left gastroepiploic artery: superior greater curvature 2. Short gastric artery: fundus The stomach is innervated by sympathetic fibers (autonomic and fight or flight) that derive from the thoracic splanchnic nerves by way of the celiac plexus, and by parasympathetic fibers (autonomic and rest/digest) that derive from the vagus . The corresponding veins drain into the portal splenic and superior mesenteric veins. 23.2g: The Small Intestine The small intestine is the longest part of the alimentary canal and is where almost all absorption of nutrients occurs. During digestion the small intestine undergoes segmentation that shuffles the chyme back and forth, maximizing contact with nutrient-absorbing mucosa. Takes about 3-6 hours to go through the small intestine. The small intestine has three subdivisions; the duodenum, the jejunum and the ileum. Jejunum makes up the superior left section whereas the ilium makes up the inferior right part. Duodenum: Direct continuation of pylorus of stomach and ends at duodenal-jejunal flexure . Receives digestive enzymes from the pancreas via the main pancreatic duct . Bile comes from the liver and gallbladder via the bile duct The ducts join together to form the hepatopancreatic ampulla which opens into the duodenum at major duodenal papilla . Jejunum and Ileum: Continue the digestion and absorption process. The jejunum starts at the duodenal-jejunal flexure (top left) The ileum ends at the ileo-cecal junction (bottom right. The jejunum is more vascular and carries out more absorption. The Ileum is more lymphoid and has less absorption. Specializations (to maximize absorption): 1. Plicae circulares : circular folds of mucosa and submucosa. Swirl chyme through the intestine, slowing movement allowing more time for absorption. 2. Villi : finger-like projections of mucosa that increase surface area
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3. Microvilli : cover apical surface of enterocytes. Long and densely packed which amplifies surface area and contains enzymes that help breakdown nutrients. Histology: 1. Mucosa: 1. arranged in villi and crypts 1. Enterocytes : contain microvilli 2. Goblet cells : secrete mucus 3. Enteroendocrine cells : secrete hormones. Signal gallbladder to release bile and pancreas to release digestive enzymes and bicarbonate rich juice 4. Intestinal Crypt : contains intestinal stem cells and Paneth cells 2. Lamina propria has vessels that carry absorbed products or proteins and carbohydrates. Lacteals carry absorbed fats. 3. Muscularis mucosa help keep mucosal layer moving 2. Submucosa: 1. In duodenum only: duodenal glands open into intestinal crypts. Secretes alkaline mucus that neutralizes acidity of chyme and helps protect mucosa. 2. In distal jejunum and ileum: huge areas of lymphoid nodules monitor bacteria in intestines 3. Muscularis externa 4. Serosa The small intestine is innervated with parasympathetic fibers from the vagus nerve and sympathetic from the thoracic splanchnic nerves. Both are relayed through the superior mesenteric (and celiac) plexus. Arterial supply comes primarily from the superior mesenteric artery. The veins run parallel to the arteries and typically drain into the superior mesenteric vein. From there, the nutrient rich blood drains into the hepatic portal vein, which carries it to the liver. 23.2h: The Large Intestine The material that reaches the large intestine is largely digested residue that contains few nutrients. The main function is to absorb water and electrolytes from the digested mass, resulting in a semi-solid feces. Movement is weak and slow. Subdivides into the cecum, appendix, colon, rectum and anal canal (the colon is further divided into the ascending, transverse and descending). There are three special features of the small intestine. Teniae coli are longitudinal strips that are thickenings of the longitudinal layer of the muscularis externa. They cause the large intestine to pucker into sacs known as haustra . Epiploic appendages are fat filled pouches of visceral peritoneum that hang from the intestine. Their significance is unknown. The Large Intestine: 1. Cecum a. The large intestine begins with the cecum. The opening is surrounded internally by the ileocecal valve . Receives contents from the ileum. 1. The appendix is a blind tube that opens into the posteromedial wall of the cecum. Lots of lymphoid tissue Clinical Application: Appendicitis
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Results from a blockage that traps infectious bacteria within its lumen. Unable to empty its contents, the blocked appendix swells leading to tissue death and infection. If it ruptures, bacteria and feces are released into the peritoneum, causing peritonitis. 2. Colon 1. Four Parts: 1. Ascending Colon: connects cecum to transverse colon 2. Transverse Colon: largest, most superior and most motile part of large intestine 3. Descending Colon: non-motile. Connects transverse colon to sigmoid colon. 4. Sigmoid Colon: very motile. Connects descending colon to rectum 2. Two Flexures: 1. Hepatic flexure 2. Splenic flexure Colon Histology: 1. Mucosa o - Relatively smooth, no plica circulares or villi. Fewer nutrients are absorbed. Large crypts are present o - Colonocytes: absorb water and electrolytes o - Goblet Cells: very abundant, secrete mucus to ease passage of feces 2. Submucosa 3. Muscularis Externa - Thin except at the teniae coli 4. Serosa - Contains the epiploic appendages Rectum: - Fixed portion of LI that penetrates pelvic diaphragm. No teniae coli, but has thick, well-developed muscles that help promote defecation. - Internally there are three transverse rectal folds that prevent feces from being passed along with gas. Anal Canal: - Terminal end of the large intestine continues with rectum. Begins at levator ani and ends at anus. Internally divided by the pectinate line. Superior to pectinate line: - Visceral sensory nerves ; insensitive to pain - Continuous blood supply with GI tract - Anal columns : longitudinal folds of mucosa - Anal valves : connect adjacent anal columns - Anal sinuses : pockets formed by anal valves. Filled with mucus, which is released during defecation Inferior to pectinate line: - Somatic sensory nerves ; sensitive to pain - Distinct blood supply from rest of GI tract The wall of the anal canal contains two sphincter muscles: an internal anal sphinctor of smooth muscle and an external sphinctor of skeletal muscle . The external sphincter contracts voluntarily to inhibit defecation, whereas the internal sphincter contracts involuntarily, both to prevent feces
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from leaking. The rectum is usually empty and the anal sphincters contracted. When feces are squeezed into the rectum, the stretching of the rectal wall initiates the defecation response. The sacral spinal cord mediated this and sends parasympathetic reflux signals to the walls of the sigmoid colon and rectum to contract and the internal anal sphinctor to relax. During defecation, the muscles of the rectum contract to expel the feces. This process is supplemented by an increase in intra-abdominal pressure, and the levator ani muscle lift the anal canal superiorly. Blood Supply to Intestines: Celiac trunk : stomach, proximal half of duodenum, liver and spleen Superior mesenteric artery : distal half of duodenum, jejunum, ileum, cecum/appendix, ascending colon and 2 3 of transverse colon Inferior mesenteric artery : distalf 1 3 of transverse colon, descending and sigmoid colon, rectum and anal canal (above pectinate line, below is supplied by the inferior rectal artery. Blood supply from alimentary canal: Hepatic portal system carries absorbed nutrients from the tract directly to the liver where it can be detoxified before travelling to the heart. The tributaries are the splenic vein , superior mesenteric vein and inferior mesenteric vein . The sympathetic innervation is from the superior mesenteric and celiac ganglia and plexuses, and its parasympathetic comes from the vagus nerve. The final part of the anal canal, below the pectinate line is innervated by somatic nerves like the pudendal nerve . Peritoneal Cavity and Peritoneum The abdominopelvic cavity contains the peritoneum. We see the visceral peritoneum and parietal peritoneum just like with the lungs. Mesentery: double layer of peritoneum. Connects intraperitoneal organs with each other or to the abdominal wall. Ventral and dorsal Dorsal mesenteries - extend from posterior abdominal wall to alimentary canal 1. Greater omentum: connects greater curvature of stomach to transverse colon. Elongated anteriorly, covers the transverse colon and small intestine like an apron. 2. Mesentery: supports the jejunum and ileum. Fans inferiorly from posterior abdominal wall 3. Transverse mesocolon: connects transverse colon to posterior abdominal wall. Fused to the underside of the greater omentum. 4. Sigmoid mesocolon: connects the sigmoid colon to the posterior pelvic wall. Intraperitoneal organs: almost completely surrounded by peritoneum. Organ can freely move. (stomach, jejunum, ileum, transverse colon, sigmoid colon). Retroperitoneal organs: organ is behind peritoneum; only partly covered. Fixed position. (duodenum, pancreas, ascending and descending colon). Diverticulosis and Diverticulitis When the diet lacks fiber, contractions of the circular muscle in the colon exert greater pressures on its wall. This pressure promotes the formation of multiple sacs (diverticula). The resulting condition is diverticulosis. Typically occurs in the sigmoid colon. Leads to nothing but dull pain - although it may rupture an artery in the colon
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and produce bleeding. In some diverticulosis cases, patients develop diverticulitis, in which the inflamed diverticula become infected and may perforate, leaking feces into the peritoneal cavity. Peptic Ulcers Ulcers are craterlike erosions of the mucosa in any region of the alimentary canal exposed to stomach secretions. Majority occur in the pyloric region (gastric ulcers) or in the duodenum (duodenal ulcers). Typical symptom is chronic burning 1-3 hours after a meal. Caused by an infectious acid-resistant bacteria. It binds to the gastric epithelium and induces oversecretion of acid and inflammation. Intestinal Obstruction Any hindrance to the movement of chyme or feces is an intestinal obstruction. Most are mechanical - due to hernias or twists, intestinal tumors or adhesions, or foreign objects lodged in the bowel. Nonmechanical obstruction is due to a halt in peristalsis. Common symptoms include cramps, vomiting, nausea, and a failure to pass gas and feces. Inflammatory Bowel Disease (IBS) A noncontagious, periodic inflammation of the intestinal wall characterized by chronic leukocyte infiltration of this wall. Symptoms include cramping, diarrhea, weight loss and intestinal bleeding. Crohn’s disease is more serious, with deep ulcers and fissures developing along the entire intestine. Ulcerative colitis is characterized by a shallow inflammation of the mucosa of the large intestine, mainly in the rectum. It is an abnormal immune and inflammatory response to bacterial antigens. Treatment is a diet low in fiber and dairy, reducing stress, taking antibiotics and anti-inflammatory and immunosuppressant drugs. Cystic Fibrosis and the Pancreas CF disrupts secretions in the respiratory system, but most of the body’s other secretory epithelia are affected as well. The pancreas and intestinal glands, submandibular glands and bile ducts in the liver all become blocked with thick secretions. Clogged ducts prevent pancreatic juices from reaching the small intestine. As a result, fats and other nutrients are not digested or absorbed and the feces are bulky and fat laden. Can be treated by administering pancreatic enzymes with meals. 23.3a: The Liver The liver has over 500 functions, including: - Producing and secreting bile - Receives substances absorbed by the intestines through portal circulation - Processes and stores nutrients, minerals, glucose and glycogen; controls when to put these into blood. - Detoxifies ingested toxins Anterior Surface The liver is divided into left and right lobes, separated by the falciform ligament. Inferiorly, the falciform ligament turns into the round ligament (which is a remnant of the umbilical vein). Superiorly the falciform ligament turns into the coronary ligament Superior Surface The coronary ligament bends into the triangular ligaments (right and left) Most of the liver is covered by visceral peritoneum, except for the bare area of the liver which is not covered by pericardium (directly touching diaphragm) Two other lobes as well, more superiorly the caudate lobe and inferiorly the
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quadrate lobe Posterior The porta hepatis is where most of the major vessels and nerves enter and leave the liver. The portal triad consists of the hepatic artery, hepatic portal vein and common hepatic duct (formed by the fusing of the R and L hepatic ducts) Small branches of the portal triad are organized around hexagonal-shaped liver lobules, surrounding a central vein. Radiating from the central verin are plates of liver cells ( hepatocytes ). Blood percolates through the hepatocyte plate via large capillaries called sinusoids. Cleaned blood reaches a central vein in the middle of the lobule. Central veins drain into hepatic veins which drain into the IVC. Bile produced by hepatocytes is secreted into channels which merge to form bile ducts. Bile ducts form left and right hepatic ducts and these ducts form the common hepatic duct at the porta hepatis. Autonomic nerves come from the celiac plexus and consist of both sympathetic and parasympathetic fibers. Other important structures on the visceral surface are the gallbladder and IVC. Clinical Application: Cirrhosis Cirrhosis is the progressive inflammation of the liver, usually as a result of chronic alcoholism. The alcohol poisoned hepatocytes are continuously replaced, the liver's connective tissue regenerates faster, so the liver becomes fibrous and fatty, and its function declines. The scar tissue impedes blood flow causing portal hypertension. As toxins accumulate the patient will notice effects. 23.3b: The Gallbladder The gallbladder stores and concentrates the liver’s bile. The gallbladder has a fundus, body and neck. The gallbladder’s cystic duct joins the common hepatic duct to form the bile duct which then empties into the duodenum. The liver secretes bile continuously but sphincters at the end of the bile duct and hepatopancreatic ampulla are closed when bile is not needed for digestion. Clinical Application: Gallstones Bile is the normal vehicle in which cholesterol is excreted from the body, and bile salts keep the cholesterol dissolved within bile. Too much cholesterol or too few bile salts can lead to crystallization of cholesterol in the gallbladder producing gallstones that can plug the cystic duct and cause pain. 23.3c: The Pancreas The pancreas is both an exocrine and endocrine gland. In its endocrine function it secrete insulin and glucagon, which lower and raise blood sugar levels. The exocrine function is to produce most of the enzymes used in digestion within the small intestine. The pancreas is retroperitoneal, shaped like a tadpole and has head, body and tail, neck and uncinate process (hook-shaped projection of head of pancreas). The tail extends to touch the spleen and the head lies in the c-shaped curve of the duodenum. Exocrine Histology Most of the pancreas is acinar cells arranged in acini (sacs). Acinar cells make pancreatic juice containing enzymes and bicarbonate. Enzymes are stored and secreted as zymogens (inactive enzymes). Zymogens move from acinus via
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intralobular ducts to main pancreatic ducts. Zymogens are only active when they reach an acidic environment. Endocrine Histology The endocrine pancreas comprises 5% of the cells and are arranged in islets (of Langerhans) . These cells produce insulin, glucagon, and somatostatin. Islet cells secrete these hormones directly into the bloodstream. Main Pancreatic Duct: carries pancreatic juice from the pancreas to the duodenum. Joins with the bile duct and together they make the hepatopancreatic ampulla (of Vater) . The hepatopancreatic sphincter (of Oddi) surrounds the duct and controls the flow of bile and pancreatic juice into the duodenum. Hormones produced by the stomach and duodenum relax this sphincter and promote contraction in the pancreas and gallbladder, enabling the entry of bile and juice. The hepatopancreatic ampulla drain into the duodenum at major duodenal papilla. There is often an accessory duct that enters separately into the duodenum at the minor duodenal papilla. The pancreas receives blood through branches of the hepatic, splenic and superior mesenteric vessels. Its autonomic nerves are from the celiac plexus. Sympathetic input derives from the thoracic splanchnic nerves, whereas parasympathetic input is from the vagus nerve. Clinical Application: Pancreatitis Inflammation of the pancreas. Typically accompanied by necrosis of pancreatic tissue. Painful condition that usually arises from the blockage of the pancreatic duct. The blockage results in activation of the pancreatic enzymes in the pancreas instead of the small intestine. Can lead to nutritional deficiencies, diabetes, pancreatic infections, etc ? Week 10- Urinary System & Intro To Pelvic Anatomy The urinary system filters blood, eliminates waste, excretes excess ions and assists in blood pressure/volume regulation (maintaining homeostasis) 24.1 Kidneys The R kidney is crowded by the liver and lies slightly inferior to the left kidney. Each kidney has a renal hilum where vessels, ureters, and nerves enter and leave the kidney. The adrenal gland is on the superior part of each kidney. Several layers of supportive tissue surround each kidney. The fat layers cushion the kidney against blows and help hold the kidneys in place. - The innermost layer is the f ibrous capsule that adheres directly to the kidneys. The fibrous capsule helps maintain shape and forms a barrier that can inhibit the spread of infection from the surrounding regions. - Perirenal fat ; protect and cushion - An envelope of renal fascia that anchors kidney and adrenals in abdomen - Pararenal fat ; protect and cushion There are two distinct regions of kidney tissue: cortex and medulla. Deep to the cortex is the medulla which consists of cone-shaped masses called renal pyramids. Renal columns separate adjacent pyramids. The renal sinus is a large space within the medial part of the kidney opening to the exterior through the hilum. The renal pelvis is the expanded superior part of the ureter. Branching extensions of the renal pelvis form two or three major calices each of which divides into minor calices. The calices collect urine
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draining from the papillae and empty it into the renal pelvis. Urine flows through the renal pelvis and into the ureter which transports it to the bladder for storage. Papilla minor calyx major calyx renal pelvis ureter The kidneys receive blood via the renal arteries. The right renal artery is longer than the left because the aorta lies slightly left of the body midline. As each renal artery approaches the kidney it divides into five segmental arteries that enter the hilum. These further divide into interlobar arteries. The veins follow the same pathway in reverse. The renal vein exits at the hilum and empties into the IVC. The left renal vein is longer than the right because the IVC lies on the right side of the vertebral column. Innervation comes from the renal plexus (an offshoot of the celiac plexus). The renal plexus is supplied by sympathetic fibers from the most inferior thoracic splanchnic nerve, the first lumbar splanchnic nerve and other sources. Polycystic Kidney Disease : - Autosomal dominant trait. Can have single or multiple cysts and is often associated with renal failure. To treat, the kidney is typically left in the body and the transplanted kidney goes into the pelvis. Nephron : Functional unit of kidney 1. Renal corpuscle (glomerular capsule and glomerulus) 2. Proximal convoluted tubule 3. Nephron loop 4. Distal convoluted tubule 5. Collecting duct 24.2 Ureters Urine, collected from the renal calices and emptied into the renal pelvis, leaves the kidneys via the ureters. We see kidney stones get lodged in three places, the renal pelvis, at the pelvic brim and the bladder entrance. The ureters enter the bladder at a sharp angle which acts as a natural valve. 24.3 Urinary Bladder The empty bladder has the shape of an upside-down pyramid with four surfaces and four angles. The two posterolateral angles receive the ureters. At the bladder’s anterior angle (apex) is a fibrous band called the urachus , the closed remnant of an embryonic tube. The inferior angle (neck) drains into the urethra. In males, the prostate, a reproductive gland, lies directly inferior to the bladder, where it surrounds the urethra. In the interior of the bladder, openings for the ureters and urethra define the trigone . Infections tend to persist in this region. The arteries are branches of the internal iliac arteries. Veins draining the bladder form a plexus on the bladder’s inferior and posterior surfaces that empties into the internal iliac veins. Nerves come from the pelvic splanchnic nerves (parasympathetic fibers), a few sympathetic and visceral sensory fibers too. The bladder has three layers. A mucosa with transitional epithelium and a lamina propria which forms the inner lining of the bladder. The mucosal lining contains rugae. There is a thick detrusor muscle layer. Contraction squeezes urine from the bladder during urination. The outermost layer is the adventitia (for the lateral and inferior surfaces). The superior surface is covered by parietal peritoneum. 24.4 Urethra
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The urethra drains urine from the bladder and conveys it out of the body. Consists of smooth muscle and an inner mucosa. At the bladder-urethra junction , a thickening of the detrusor forms the internal urethral sphincter. This is an involuntary sphincter that keeps the urethra closed when urine is not being passed. The external urethral sphincter surrounds the urethra within the urogenital diaphragm. It is used voluntarily to inhibit urination. The female urethra is much shorter than the male urethra. In females, the urethra is bound to the anterior wall of the vagina by connective tissue. It opens to the outside at the external urethral orifice. The male urethra has three named regions: the prostatic urethra, the intermediate part of the urethra and the spongy urethra . The spongy urethra passes through the entire penis and opens at the tip of the penis via the external urethral orifice. Carries the ejaculate as well. 24.5 Micturition Micturition is the act of emptying the bladder. Brought about by the contraction of the detrusor muscle (assisted by the muscles of the abdominal wall). Controlled by the brain and involves autonomic and somatic pathways. As urine accumulates stretch receptors are activated which send sensory impulses through the visceral sensory neurons to the sacral region of the spinal cord, and then up to a micturition centre in the dorsal part of the pons. The neurons in the pons signal the parasympathetic neurons that stimulate contraction of the detrusor which empties the bladder. At the same time, the sympathetic pathways to the bladder which would prevent micturition by relaxing the detrusor muscle are inhibited. The somatic motor neurons to the urethral sphincter are also inhibited, relaxing the muscle and allowing urine to pass through the urethra. Pelvic Wall Muscles: piriformis and obturator internus Pelvic Floor Muscles: Coccygeus and levator ani (iliococcygeus, pubococcygeus, puborectalis) . Perineum is positioned tangential to the curve of the pelvic floor. Pudendal nerve? Urogenital Diaphragm: superior urogenital fascia, deep perineal pouch, perineal membrane, deep transverse perineal membrane, external urethral sphincter, internal pudendal vein and dorsal nerve of penis/clitoris, bulbourethral glands (males only), compressor urethrae (females only), and urethrovaginal sphincter (females only) . Perineum: Superior urogenital fascia, deep transverse perineal muscle, perineal membrane, bulbospongiosus (covering bulb of penis), ischiocavernosus (covering crus of corpora cavernosus), Colles’ fascia. It is a diamond shaped region containing a urogenital triangle and anal triangle. Several potential spaces exist formed by the convoluted fascial arrangements. Spaces: Infraperitoneal space Ischioanal fossa Deep perineal pouch Superficial perineal pouch Subcutaneous tissue Urogenital and Anal Triangles Urogenital Triangle (anterior): ischiopubic rami and posterior border of urogenital diaphragm Anal Triangle: Inferior borders of gluteus maximus and posterior border of urogenital diaphragm Anorectal Flexure - angle between the anal canal and rectum. The angle is decreased by the contraction of the levator ani muscle.
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? Week 11+12- Reproductive System 3:25 PM In the male reproductive system, gonads/testes ductoral system (duct of the epididymis, the ductus deferens, the ejaculatory duct and the urethra) sex glands (seminal glands, prostate and bulbourethral) The female reproductive organs differ in several important ways. In addition to producing eggs, the female reproductive organs also prepare to support a developing embryo during pregnancy. Second, the female organs undergo changes according to the menstrual cycle. The primary female reproductive organs are the ovaries. The accessory ducts include the uterine (fallopian) tubes, the uterus, and the vagina. The female external genitalia are referred to as the vulva. 25.1a The Testes Descent of the Testis: The gubernaculum shortens thereby pulling the testis into the scrotum. The layers are continuous with layers of the abdominal wall. - Dartos muscle (from subcutaneous fascia)(can wrinkle to bring closer to bodyO - External spermatic fascia (from external oblique) - Cremaster muscle (from internal oblique)(responsible for elevation) - Internal spermatic fascia (from transversalis fascia) - Extraperitoneal fat - Parietal layer of tunica vaginalis (tunica vaginalis is from peritoneum) - Cavity of tunica vaginalis - Visceral layer of tunica vaginalis Inguinal Canal : transversus abdominis and internal oblique (roof), Aponeurosis of external oblique (anterior wall), Conjoint tendon and Inferior epigastric artery (posterior wall), Deep ring (entrance), Superficial ring (exit). The canal runs laterally to the deep inguinal ring. This is where the vas deferens and testicular vessels enter the pelvic cavity. An inguinal hernia is when the intestines pass through a patent tunica vaginalis. Vas Deferens : Within spermatic cord and carries sperm. Connects testis with the seminal vesicles and ejaculatory ducts. Seminal Vesicles : Join with vas deferens to form an ejaculatory duct. Seminal secretions are rich in fructose and prostaglandins Prostate Gland : Contains urethra and two ejaculatroy ducts. Secretions are rich in citric acid and enzymes and proteases. Bulbourethral Glands : lubricates urethra and neutralizes acidity. Male Urethra : bladder prostatic urethra (contains ejaculatory ducts) membranous urethra (contains bulbourethral glands) penile urethra - Testes is partially enclosed by tunica vaginalis (three layers). - Tunica albuginea is a fibrous capsule around the testis that has septal extensions which divide the testes into lobules (this is where the seminiferous tubules are) - Out of the testes: seminiferous tubules rete testis efferent ductules that enter epididymis (sperm mature here and are emptied into the duct of epididymis during ejaculation) - The urethra carries sperm from the ejaculatory ducts to the outside of the body. Its three parts are
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the prostatic urethra in the prostate, the intermediate part of urethra in the urogenital diaphragm and the spongy urethra in the pinis. The mucosa of the spongy urethra contain urethral glands that secrete mucus to help lubricate the urethra Spermatic Cord: Tube of fascia containing testicular vessels and nerves. Inferiorly in the scrotum, superiorly runs through the inguinal canal. 25.1b Male Reproductive Ducts After expulsion from the epididymis, the vas deferens (ductus deferens) stores and transports sperm. Vas goes through the inguinal canal and lateral abdominal wall to enter the pelvic cavity. Near the bladder its distal end expands as the ampulla of the ductus deferens and joins with the duct of the seminal gland to make the ejaculatory duct . The ejaculatory duct runs within the prostate and empties into the prostatic urethra. 25.1c Accessory Glands The glands produce the semen (sperm plus secretions of the accessory glands and accessory ducts). The seminal glands lie on the posterior surface of the bladder. A thick layer of muscle surrounds the mucosa and contracts during ejaculation to empty the gland. The secretions of the seminal glands constitute 60% of the semen volume. It includes fructose and other nourishment for the sperm, prostaglandins which stimulate the contraction of the uterus to help move sperm through the female reproductive tract, substances that suppress the immune response against semen in females, substances that enhance sperm motility, enzymes that clot the ejaculated semen in the vagina and then liquefy it so the sperm can swim out. Sperm and seminal fluid mix in the ejaculatory duct and enter the prostatic urethra together. The prostate glands constitute about 1 3 of the volume of semen. It also contains various substances to increase sperm motility and enzymes that clot then liquify ejaculated semen. The bulbourethral glands are small and inside the urogenital diaphragm. They produce a mucus that enters the spongy urethra when a man becomes sexually excited prior to ejaculation. It neutralizes any trace of acidic urine and lubricates the urethra 25.1d The Penis The penis delivers sperm into the female reproductive tract. The penis consists of an attached root and a free body that ends in a large tip ( glans penis ). There is loose skin covering the penis (foreskin). Internally, the penis contains the spongy urethra and three long cylindrical bodies of erectile tissue. The corpus spongiosum is enlarged distally where it forms the glans penis and proximally where it forms a part of the root called the bulb of the penis. The corpora cavernosa makes up most of the mass of the penis. Their proximal ends in the root are crura of the penis . The sensory dorsal nerves are branches of the pudendal nerve from the sacral plexus and the dorsal arteries are branches of the internal pudendal arteries from the internal iliac arteries . Two dorsal veins lie in the dorsal midline and drain all blood from the penis. A deep artery runs within each corpus cavernosum. The autonomic nerves follow the arteries and arise from the inferior hypogastric plexus in the pelvis. The male sexual response has chief phases: erection and ejaculation. During sexual stimulation, parasympathetic innervation dilates the arteries supplying the erectile
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bodies increasing the blood flow to the vascular spaces within. Swelling occurs. There are strong muscular fibers that ensure the penis does not buckle of kink during intercourse. Erection is under parasympathetic control, ejaculation is under sympathetic control. Begins with muscle contraction and causes constriction of the internal urethral sphincter. Penile Neurovasculature - Dorsal nerve of the penis (sensations)(branch of pudendal nerve) - Deep dorsal vein of the penis - Dorsal artery of the penis (branch of internal pudendal artery) - Deep (cavernous) artery of the penis - Helicine artery 25.1e The Male Perineum Contains the scrotum, the root of the penis and the anus. The floor is formed by the muscles of the urogenital diaphragm and the superficial perineal space. Female Pelvic Organs and Genitalia Female Pelvic Organs - Ovary - Fallopian Tube (fimbriae, infundibulum, ampulla, isthmus) - Uterus - Rectum - Bladder - Urogenital diaphragm Vagina : Tubular fibromuscular pelvic organ (the fornix is the circumferential recess around the cervix. Orientation of the Uterus: Angle of Version: uterine axis and axis of vagina Angle of Flexion: uterine axis and cervical axis Ante-: acute angle (of version or -flexion) Retro-: Obtuse angle (of version or -flexion) Typically we see anteverted anteflexed uterus’ Menstruation and Hormone Cycles: - LH and FSH surge induce ovulation after rising estrogen levels. - Progesterone rises from the remaining corpus luteum which stimulates growth of the functional layer of endometrium. - If no fertilization, progesterone drops, inducing shedding of the functional endometrium Pregnancy Implantation of the embryo causes the release of hCG that supports the corpus luteum (keeps progesterone levels from falling) until the placenta develops (placenta then produces progesterone). Hysterosalpingography: contrast medium injected into the uterus. Used to determine patency. Tubal Ligation: surgical method of birth control. Uterine tubes are cut, cauterized or clipped to prevent joining of egg and sperm. Uterine ligaments: Peritoneal Folds: Broad Ligament: mesovarium, mesosalpinx, mesometrium Suspensory ligaments Developmental Remnants: Ovarian ligament and round ligament Endopelvic Fascia - The hypogastric sheath is the unified origin of the two (female) or three (male) fascia septa.
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- Loose areolar endopelvic fascia fills the space between the more ligamentous fascia septa - Some special parts have their own names to emphasize a specific purpose Components: lateral ligament of the rectum, cardinal (transverse cervical) ligament, lateral ligament of the bladder. Uterosacral ligament (constituent of the cardinal ligament), pubocervical ligament (constituent of the lateral ligament of the bladder), pubovesical ligament (constituent of the lateral ligament of the bladder). - The cardinal ligament and uterosacral ligament form a sling (true supporting ligaments of the uterus and bladder). The pubocervical fascia form a nice wrap. If damaged during childbirth the uterus can invert and fall. - Several ligaments and mesenteries help hold the uterus in place. The mesometrium anchors to the lateral pelvic walls. Inferiorly, the transverse cervical (cardinal) ligaments run horizontally from the cervix and superior vagina to the lateral pelvic walls. The uterus is bound to the anterior body wall by the paired round ligaments of the uterus. Despite the ligaments the uterus is supported chiefly by the pelvic floor muscles (namely the muscles or the urogenital and pelvic diaphragms). If these muscles are torn during childbirth the uterus can sink Vestibular Glands - Secrete mucus into the vestibule. The greater vestibular glands have increased secretions during sexual arousal (PSNS). The lesser vestibular glands secrete with orgasm (PSNS) and have potential anti-microbial function. Clitoris : Innervation by the dorsal nerve of the clitoris (from pudendal nerve). Has a crus, angle, body and glans. 25.2a The Ovaries - Held in place by mesenteries and ligaments from the peritoneum (broad ligament, suspensory ligament (ovary to lateral pelvic wall), ovarian ligament (ovary to uterus) - Ovarian arteries and uterine arteries. Reach ovary by travelling within the suspensory ligament - Innervation by sympathetic and parasympathetic nervous system - Surrounded by tunica albuginea (covered by germinal epithelium). Ovary is divided into the outer cortex (houses oocytes) and inner medulla. The deep ovarian medulla contains the largest vessels and nerves; enter through the hilum. - Ovary Internal Structure: Primordial follicle primary follicle secondary follicle tertiary follicle ovum developing corpus luteum corpus luteum degenerating corpus luteum 25.2b The Uterine Tubes (AKA fallopian tubes) - Receive ovulated oocyte and are the site for fertilization - Infundibulum opens into the peritoneal cavity (to capture oocytes). Has fimbriae that drape the ovary. Largest section of the tube is the ampulla (fertilization usually occurs here). Final third is the isthmus - The tube is covered by peritoneum and supported by an offshoot of the broad ligament.
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- Ectopic pregnancies usually occur in the tubes. 25.2c The Uterus - Receives, retains and nourishes fertilized egg (egg enters at the fundus) - Divided into the body, isthmus (narrow neck), and cervix (continuation of narrow neck) - Cervical canal secretes a mucus that blocks the spread of bacteria from vagina to uterus and blocks sperm, except at midcycle. - From outer to inner wall: perimetrium (serous membrane) myometrium (smooth muscle that contracts during childbirth) endometrium - The endometrium has two chief layers: the functional layer and the basal layer. The thick, inner functional layer is shed and undergoes changes as a result of varying levels of hormones in the blood. The thin basal layer is not shed and is responsible for forming a new functional layer after menstruation ends. - Blood supply from uterine arteries 25.2d The Vagina - Anterior to rectum; posterior to urethra - Wall has three coats: adventitia muscularis inner mucosa (marked by rugae that stimulate penis during intercourse)(has lamina propria that allow vagina to return to original shape and stratified squamous epithelium to resist friction and bacteria 25.2e The External Genitalia and Female Perineum - Overall external genitalia is the vulva - Mons pubis: fatty, rounded pad overlying the pubic symphysis - Labia: majora (encloses) labia minora (encloses vestibule) - Vestibule: houses the opening of the urethra and vagina. The vaginal orifice is posterior to urethra orifice. Lateral are the greater vestibular glands that lubricate. Homologous bulbs of the vestibule lie along each side of the vaginal orifice and directly deep to the bulbospongiosus muscle. - Frenulum of the labia: formed by the coming together of the right and left labia - Clitoris: anterior to the vestibule. Body contains a paired corpora cavernosa, which continue posteriorly into crura - Perineum is a region between the pubic arch (anteriorly), coccyx (posteriorly), and ischial tuberosities (laterally). Perineal body is in the exact center and is the insertion point of most pelvic floor muscles. Neural Control of Male Sexual Function : Point (parasympathetic) and Shoot (sympathetic). Erection has PSNS efferents. Psychological stimuli or pudendal nerve (from penis sensation) sacral spinal cord efferent PSNS Nitric oxide cGMP vasodilation of cavernous artery erect The nerves branch from the pelvic splanchnic nerves. Ejaculation has SNS efferents, somatic efferents and PSNS efferents. Afferent stimulation (pudendal nerve) which makes its way to the spinal ejaculation generator and consists of two phases.
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Sympathetic Nuclei leads to smooth muscle contraction of bladder neck which functions for expulsion and the seminal vesicles, prostate gland and vas deferens which have seminal emission Parasympathetic nuclei epithelial secretions from prostate gland and seminal vesicles (seminal emission) Onuf’s nuclei rhythmic contractions of bulbospongiosus and ischiocavernosus (expulsion) Sympathetic Outflow: in the sympathetic trunk postganglionic sacral splanchnic nerve exits and goes to genitals and urinary bladder. Also from the trunk, preganglionic lumbar splanchnic nerves go to the infrarenal ganglia (of the aortic plexus) and synapse. The postganglionic then travels to the superior hypogastric plexus that then goes to the genitals and urinary bladder. Autonomic Outflow: Superior hypogastric plexus (SNS from aortic plexus, PSNS from pelvic splanchnic nerve) left hypogastric nerve, sacral splanchnic nerve (SNS) (goes to inferior hypogastric plexus), pelvic splanchnic nerve (PSNS). Phase one: Seminal Emission Psychological stimuli or dorsal nerve of penis (and then the pudendal nerve) lumbosacral spinal cord Lumbar SNS and Sacral PSNS Smooth muscle contraction of the prostate, seminal vesicles and vas deferens transports semen into the proximal (prostatic) urethra. Phase two: Expulsion 1. Semen in the proximal urethra 2. Dorsal nerve of penis Internal pudendal nerve (visceral afferents) lumbosacral spinal cord lumbar SNS (internal urethral sphincter contracts) OR pudendal nerve (involuntary rhythmic contraction of the ischiocavernosus, bulbospongiosus and other perineal muscles) Internal Urethral Sphincter 1. Semen enters prostatic urethra 2. Internal urethral sphincter contracts (SNS) 3. Forward flow ejaculation 4. Internal urethral sphincter is paralyzed (open, loss of SNS) 5. Backwards flow ejaculation Neural Control of Female Sexual Function Arousal: PSNS efferents Orgasm: SNS efferents, somatic efferents, PSNS efferents. Arousal pathway: 1. Psychogenic or other erogenous stimuli to sacral spinal cord OR dorsal nerve of clitoris to pudendal nerve to sacral spinal cord 2. Pelvic splanchnic nerve (efferent PSNS) 3. Nitric oxide that leads to vasodilation of cavernous and vaginal artery OR vaginal lubrication by greater vestibular glands. Sexual Refractory Period: Males experience significant inhibition following ejaculation. The refractory period in females is far less prominent, owing to the ability of multiple orgasms
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