Anatomy notes
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Western University *
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Subject
Anatomy
Date
Oct 30, 2023
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Week 1- Introduction & Nervous System
pt.1
Anatomical position
Superior (cranial):
toward the head end or upper part of a structure or the
body; above
o
ex: the head is superior to the abdomen
Inferior (caudal)
: away from the head end or toward the lower part of a
structure or the body; below
o
ex: the navel is inferior to the chin
Anterior (ventral)
: toward or at the front of the body; in front of
o
ex: the breastbone is anterior to the spine
Posterior (dorsal)
: toward the back of the body; behind
o
ex: the heart is posterior to the breastbone
Medial:
toward or at the midline of the body; on the inner side of
o
ex: the heart is medial to the arm
Lateral:
away from the middle of the body; on the outer side of
o
ex: the arms are lateral to the chest
Proximal
: closer to the origin of the body part or the point of attachment of a
limb to the body trunk
o
ex: the elbow is proximal to the wrist
Distal:
farther from the origin of a body part or the point of attachment of a
limb to the body trunk
o
ex: the knee is distal to the thigh
Superficial:
toward or at the body surface
Deep (internal):
away from the body surface; more internal
Ipsilateral:
on the same side
Contralateral:
on opposite sides
Planes of section through body
Sagittal (median): front middle
Frontal (coronal): side middle
Transverse: dividing upper and lower body
Body movements
Flexion: decreasing the angle of a joint
extension: increasing the angle of a joint
Abduction: movement away from the midline
Adduction: movement toward the midline
Lateral/ medial rotation
Division of the nervous system:
Central nervous system
peripheral nervous system
sensory (afferent) division, motor (efferent) division
Somatic nervous system
Autonomic nervous system
Sympathetic division, parasympathetic division
What is a spinal nerve?
Part of the peripheral nervous system
Mixed nerve carrying motor and sensory information between the spinal cord
and body
31 pairs of spinal nerves
Bony framework:
Vertebrae surround spinal cord
Spinal nerves exit between the vertebrae at the intervertebral foraman
o
Foraman between two vertebrae
During fetal growth the spinal column grows at a faster rate than the spinal
cord
Sections of the spine and number of vertebrae in each
cervical: 7
thoracic: 12
lumbar: 5
Sacral: 5
coccygeal: 1
Sections of the spinal cord and number of nerves in each
cervical: 8
thoracic: 12
lumbar: 5
Sacral: 5
Coccygeal: 1
How far does the spinal cord go
about to L1 then it is just nerves
Where do nerves exit
cervical: EXIT ABOVE VERETBRAE
lumbar, thoracic, sacral: exit below
Spinal cord to spinal nerve flow
spinal cord - dorsal rootlets - dorsal root - spinal nerve - ventral rootlets - ventral
root- spinal nerve divides into dorsal ramus and ventral ramus
ventral root and rootlets: MOTOR
dorsal root and rootlets: SENSORY
the motor nerves stop at muscle and then the sensory ones continue onto the
skin
Dermatomes
area of skin innervated by a single spinal nerve
Important for diagnosing spinal injuries and shingles (varicella-zoster virus)
Motor function:
Each terminal branch applies a group of muscles within the upper limb
Terminal branch
Muscle group
Muscle example
musculocutaneous
Arm flexors
Biceps brachii
median
Forearm and hand flexors
Flexor digitorum
radialis
ulnar
Forearm and hand flexors
Flexor digitorum ulnaris
radial
Arm and forearm extensors
Triceps brachii
axillary
shoulder
deltoid
Brachial plexus
network of nerves that supply the upper limb
begins at neck and ends at armpit, terminal branches continue down the
length of arm
formed by the ventral ramus
brachial plexus terminal branches have mixed function (both sensory and
motor)
multiple spinal levels compose muscles - therefore damage may just cause
weakness but not total paralysis, however sensory region would be entirely
knocked out
Organization of the brachial plexus
roots, trunks, divisions, cords, branches
o
(really thirsty drink cold beer)
roots of brachial plexus: C5, C6, C7, C8, T1
trunks of brachial plexus: superior, middle, inferior
divisions of brachial plexus: 3 anterior and 3 posterior cords of brachial
plexus: lateral, posterior, medial
branches of brachial plexus: musculocutaneous, axillary, radial, median,
ulnar, musculocutaneous nerve
arm flexors - coracobrachialis, biceps brachii, brachialis
c5, c6, c7
o
median nerve
o
forearm and hand flexors
c5,c6,c7,c8,t1
o
ulnar nerve
o
forearm and hand flexors
c8, t1
o
radial nerve
o
forearm and arm extensors
triceps
o
C5, C6, C7, C8, T1
axillary nerve
shoulder - deltoid and teres minor
o
c5 c6
pectoral girdle
o
scapula (posterior) and clavicle (anterior)
♀
Week 2- Shoulder & Arm
The shoulder is not a true girdle
- scapula do not meet in the back
function: attachment of upper limb to skeleton, movement and flexibility in
various planes
o
this extra mobility results in a trade off of weakness and proneness to
injury
Clavicle 2 ends
o
sternal end - attaches to manubrium of sternum
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o
acromial end - attaches to acromium process of scapula
function of clavicle
o
provides muscle attachment
o
acts as brace for the scapula and arms
o
transmits compression force
fracture of clavicle
o
occurs in center
o
side with the fracture will collapse medially and droop - very easy to
see its "braceing" function
Scapula
located on dorsal rib cage between ribs 2 and 7
3 borders and angles of scapula
o
superior, medial (next to spinal column)
o
lateral (ends in glenoid fossa where humerus connects)
lateral (glenoid fossa)
superior (superior and medial meet)
inferior (medial and lateral meet)
Other features of scapula
subscapular fossa (front)
infraspinous fossa
supraspinous fossa
acromium
spine (on posterior)
coracoid process
Prime mover
major action (agonist)
antagonist: muscle that opposes action
synergist: muscle that assists a prime mover
Movements of the scapula
Elevation/Depression (shrugging)
Retraction/Protraction (punching)
Upward rotation/Downward rotation (arms overhead)
Muscles of posterior thorax
1.
trapezius
2.
levator scapulae
3.
rhomboids (major and minor)
Trapezius
origin: medial third of superior nuchal line, nuchal ligament, occipital
protuberance, spinal processes C7-T12
insertion: lateral third of clavicle, acromium, spine of scapula
action: elevate (superior fibers), retract (medial fibers), rotate scapula,
inferior depress scapula
innervation - accessory nerve (CN XI)
Levator scapulae
origin: transverse processes of vertebrae c1-c4
insertion: top of medial scapula
Action: elevate and rotate scapula inferiorly
innervation: dorsal scapular (c5) and cervical nerves (c3-c4)
Rhomboids
origin:
o
minor - nuchal ligament and spinous processes c7-T1
o
major - spinous processes t2-t5
insertion: medial border of scapula
action: retract and rotate scapula, attaches scapula to thoracic wall
innervation - dorsal scapular nerve
Muscles of anterior thorax:
1.
pectoralis minor
2.
serratus anterior
3.
subclavius
Pectoralis minor
origin: ribs 3-5
insertion: coracoid process of scapula
action: lifts scapula anteriorly and inferiorly
innervation: medial pectoral nerve
Serratus anterior
Origin: fleshy slips from upper ribs
Insertion: bottom part of medial margin of the scapula
innervation: long thoracic nerve
Actions: protracts and stabilizes scapula, assists in upward rotation
Subclavius
stabilizes and depresses pectoral girdle
Rotator cuf
4 muscles that originate on scapula and CROSS SHOULDER JOINT to insert on
humerus
1.
subscapularis
2.
supraspinatus
3.
infraspinatus
4.
teres minor
Subscapularis
this guys on the front
Insertion: LESSER tubercle
Action: medial (internal rotation)
Innervation: subscapular nerve
Supraspinatus
Action: abducts arm and prevents downward dislocation
Innervation: suprascapular nerve
Infraspinatus
Action: lateral rotation
Innervation: suprascapular nerve
Teres minor
Action: lateral rotation (outward)
Innervation: axillary nerve
which muscles of rotator cuf rotate?
1.
Subscapularis
2.
Infraspinatus
3.
teres minor
which muscle of rotator cuf abducts?
1.
supraspinatus
Humerus
proximal end - head attaches to glenoid cavity
distal end - meets radius and ulna and forms elbow joint
humerus epicondyles
o
2: lateral and medial
o
these are attachment sites for muscles:
condyles of humerus trochlea - attaches to ulna
capitulum - attaches to radius
other bony features of humerus
o
radial grove
o
deltoid tuberosity
o
greater and lesser tubercule
o
intertubercule sulcus
o
radial fossa and coronoid foss - anterior
o
olecranon fossa - posterior side
glenohumeral joint
shoulder joint - most common site of dislocation
o
most are on the anterior plane
radius is always thumb side
Anterior muscles of the arm
FLEXION:
1.
pectoralis major
2.
Coracobrachialis
3.
posterior muscles of the arm
EXTENSION:
1.
teres major
2.
latissimus dorsi
pectoralis major
Origin: clavicular head to medial part of clavicle, Sternocostal head: anterior
surface of the sternum, the superior six costal cartilages, and the aponeurosis
of the external oblique muscle
insertion: Lateral lip of the intertubercular groove of humerus
Actions: flexion, adduction, medial rotation of shoulder
innervation: lateral and medial pectoral nerves
Coracobrachialis
Origin Coracoid process of scapula
Insertion: middle third of Medial humerus
innervation: Musculocutaneous nerve
action: flexes and adducts the arm
teres major
origin: dorsal surface of inferior angle of scapula
insertion: intertubercular groove of humerus
action: extends, adducts and medially rotates arm
innervation: lower scapular nerve
latissimus dorsi
Origin: Spinous processes of vertebrae T7-L5, thoracolumbar fascia, iliac
crest, inferior 3 or 4 ribs
Insertion: intertubercular groove of the humerus
Nerve: Thoracodorsal nerve
Actions: Adducts, extends and medially rotates shoulder
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Deltoid
composed of 3 sets of fibers: anterior, medial and posterior
origin: lateral 1/3 of clavicle, acromium and spine of scapula
insertion: deltoid tuberocity
action:
o
anterior - flex and medially rotate
o
medial: abducts
o
posterior -extends and laterally rotates
innervation: axillary
Upper crossed syndrome
TIGHT: Upper Traps, levator scap,
TIGHT: pectorals
WEAK: deep neck flexors, lower traps and serratus anterior
an example of needing balance in the body: strengthen your lower tramps,
rhomboids and stretch the tight muscles
Postural Changes:
Forward Head Posture
o
increased cervical lordosis
o
increased thoracic kyphosis
o
fwd & protracted shoulders
o
rotation and abduction or winging of scapulae
o
compartments of the limbs
o
dense fibrous connective tissue divide the muscles of the limbs into
compartments
each compartment muscles are innervated by the same nerve and have similar
actions
opposite compartments = agonists/antagonists for each other
compartment syndrome
Increased pressure within a compartment = insufficient blood supply to the
tissue within that space
fascia does not allow for expansion
can lead to loss of myoneural function and necrosis
amputation may be necessary
occurs in both upper and lower limbs
anterior and posterior compartments of the arm
cross the elbow and regulate movement
o
pronation/supination
o
flexion/extension
Anterior Compartment of the arm
1.
biceps brachii
2.
Brachialis
3.
coracobrachialis
the FLEXORS
biceps brachii
Origin
o
Short head: coracoid process of the scapula.
o
Long head: supraglenoid tubercle
Insertion: Radial tuberosity and bicipital aponeurosis of forearm
innervation: Musculocutaneous nerve
Action: Flexes elbow, supinates forearm
Brachialis
origin: distal portion of anterior humerus
insertion: coronoid process and tuberocity of ulna
action: flexor of forearm
innervation: musculocutaneous (and radial)
Posterior compartment of arm
EXTENSORS
1.
triceps brachii
2.
Anconeus
triceps brachii
Origin:
o
Long head- infraglenoid tubercle of scapula
o
lateral head- posterior humerus (below grove)
o
medial head- posterior humerus (above grove)
Insertion: proximal end of Olecranon of ulna and forearm fascia
Action: Powerful forearm extensor, long head steadys abducted humerus
head
innervation: radial nerve
?
Week 3- Forearm (extenders) & Hand
carpal bones
some lovers try positions they cant handle
1.
scaphoid
2.
Lunate
3.
Triquetrum
4.
Pisiform
5.
Trapezium
6.
trapezoid
7.
Capitate
8.
hamate
bones of the hand
carpals, metacarpals, proximal, intermediate and distal phalanges
thumb has no intermediate phalange
superficial muscles of anterior forearm
1.
pronator teres
2.
flexor carpi radialis
3.
palmaris longus
4.
flexor carpi ulnaris
Pronator teres
Origin: medial epicondyle of humerus and coronoid process of ulna
Insertion: Middle of the lateral surface of radius
Innervation: median nerve
Action: pronation of forearm, flexes elbow
palmaris longus
Origin: medial epicondyle of humerus
Insertion: palmar aponeurosis and distal 1/2 of flexor retinaculum
Innervation: median nerve
Action: weak wrist flexor and tightens palmar aponeuerosis
little functional value - used as a donor tendon
o
some people do not even have this
flexor carpi radialis
Origin: medial epicondyle of humerus (common flexor tendon)
Insertion: Bases of second metacarpals
Innervation: Median nerve
Action: Flexion and abduction at wrist
flexor carpi ulnaris
Origin:
o
humeral head: Medial epicondyle
o
ulnar head: olecranon and post. border of ulna
Insertion; Pisiform, hook of the hamate, base of the fifth metacarpal bone
Innervation: ulnar nerve
Action: Flexion and adduction of wrist
Middle muscle of forearm (anterior)
flexor digitorum superficialis
Origin
o
humeral head: medial epicondyle, coronoid process of ulna, ulnar
collateral ligament
o
radial head:top 1/2 of the front of the radius
Insertion: middle of your 2-5 digits
Innervation: median nerve
Action: flexor of middle phalanges at proximal interphalangeal joints (not
thumb) and proximal phalanges at metacarpalphalangeal joints
deep muscle of anterior forearm
1.
flexor digitorum profundus
2.
flexor pollicis longus (thumb)
3.
pronator quadrus
flexor digitorum profundus
Origin: upper 3/4 of the anterior and medial surfaces of the body of the ulna,
interosseous membrane
Insertion: base of the
distal
phalanges of digits 2-5
Innervation:
o
digits 4 and 5 - ulnar nerve
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o
digits 2 and 3 - median nerve
Action: assists with flexion of hand and flexes distal phalanges at
interphalangeal joints (2-5)
flexor pollicis longus
Origin: anterior of radius and the adjacent interosseus membrane.
Insertion: The base of the distal phalanx of the thumb
Innervation: Anterior interosseous nerve (from median nerve)
Action: Flexion of the thumb.
pronator quadratus
Origin - distal 1/4 of front of ulna
Insertion - distal 1/4 of front of radius
Innervation: anterior interosseous nerve (from median nerve)
Action: pronates the forearm, fibres bind the radius and ulna together
Brachioradialis
Origin: proximal 2/3 of lateral supracondylar ridge of humerus
Insertion: lateral surface of bottom of radius
Action: forearm flexion
innervation: radial nerve
o
lateral 1/2 is innervated by the median nerve
o
technically a posterior compartment muscle
hangboard training
deep holes = superficial muscles
shallow - recruit deeper muscles
golf elbow
MEDIAL epicondylitis , Wrist FLEXOR injury, repetitive injury
carpal tunnel syndrome
compression of the median nerve as it passes between the ligament and the
bones and tendons of the wrist
cutaneous innervation of hand
1.
Radial nerve- most of the back of the hand, including the thumb
2.
Medial nerve- most of the palm of the hand, including the thumb
3.
Ulnar nerve- the pinky and half the ring finger, both sides
Hand of Benediction
damage to MEDIAN nerve resulting in loss of flexion of digits 2 and 3
wrist drop
radial nerve injury
common with fracture of humerus
claw hand
ulnar nerve injury
no tight grip
superficial muscles of posterior forearm
1.
extensor carpi radialis longus
2.
extensor carpi radialis brevis
3.
extensor digitorum (digiti minimi)
4.
extensor carpi ulnaris
extensor carpi radialis longus
Origin: lateral supracondylar ridge of humerus
Insertion: base of 2nd metacarpal
Innervation: radial nerve
Action: extensor at the wrist joint, abducts the hand at the wrist
extensor carpi radialis brevis
Origin: Lateral epicondyle of humerus
Insertion: Base of third metacarpal bone
Action: Extension and abduction at wrist
innervation: deep branch of radial nerve
extensor digitorum
origin: lateral epicondyle of humerus
insertion: extensor expansions of digits 2-5
action: extends digits 2-5 at metacarpophalangeal joints and extends hand at
the wrist joint
innervation:: posterior interosseaus nevre (from radial nerve)
extensor carpi ulnaris
Origin: Lateral epicondyle of the humerus
Insertion: base of 5th metacarpal
Action: Extends and adducts the hand at wrist joint
innervation: posterior interosseus nerve (radial nerve)
Deep muscles of the posterior forearm
1.
Supinator
2.
abductor pollicis longus
3.
extensor pollicis brevis
4.
extensor pollicis longus
5.
extensor indicis
supinator
Origin: Lateral epicondyle of humerus, supinator fossa, radial ligaments, crest
of ulna
Insertion: Radius
Action: Supinates forearm
innervation: deep branch of radial nerve
abductor pollicis longus
Origin: Posterior surface of middle of radius, ulna, and interosseous
membrane
Insertion: Base of 1st metacarpal bone
Action: Abduction and extension of thumb at CMC and radial deviation of
wrist
Innervation: posterior interosseus nerve (Radial Nerve)
extensor pollicis longus
Origin: Posterior surface of middle of ulna and interosseous membrane
Insertion: Base of distal phalanx of thumb
Action: Extension of thumb at CMC and IP joints
Innervation: posterior interosseus nerve - Radial Nerve
extensor pollicis brevis
Origin: Posterior surface of middle of radius and interosseous membrane
Insertion: Base of 1st proximal phalanx
Action: Extension of proximal phalanx of thumb at CMC joint
Innervation: Radial Nerve (posterior interosseus nerve)
Extensor Indicis
Origin: Posterior surface of ulna + interosseus membrane
Insertion: Extensor expansion of 2nd digit (index finger(
Action: Extension of index finger + helps extend hand
Innervation: posterior interosseus nerve - Radial Nerve
anatomical snuf box
contains the radial artery, cutaneous branch of radial nerve, scaphoid bone
tennis elbow
Lateral epicondylitis
Common extensor origin
opposable thumbs
only digit that can "turn back"
allows us to have a power grip and precision grip
fine motor movements
1.
extrinsic muscles of thumb
2.
Flexor pollicis longus
3.
Extensor pollicis longus
4.
Extensor pollicis brevis
5.
Abductor pollicis longus
intrinsic muscles of the thumb
1.
adductor pollicis
2.
flexor pollicis brevis
3.
opponens pollicis
4.
abductor pollicis brevis
3 groups of intrinsic muscles of the hand
thenar (4)
hypothenar (3)
palmar
lumbricals (4)
interosseus (3 PAD, 4 DAB)
1.
thenar muscles
2.
abductor pollicis brevis
3.
flexor pollicis brevis
4.
opponens pollicis
5.
adductor pollicis
abductor pollicis brevis
Origin: flexor retinaculum, the scaphoid and trapezium
Insertion: base of proximal phalanx of thumb
Innervation: Recurrent branch of the median nerve
Action: Abduction of the thumb and helps with opposition
flexor pollicis brevis
Origin: flexor retinaculum, the scaphoid and trapezium
Insertion: base of proximal phalanx of thumb
Innervation: Recurrent branch of the median nerve
Action: Flexes the thumb
Opponens Pollicis
Origin: flexor retinaculum, the scaphoid and trapezium
Insertion: lateral side of 1st metacarpal
Innervation: Recurrent branch of the median nerve
action: opposition of thumb
adductor pollicis
Origin
o
Transverse head: anterior body of the 3rd metacarpal
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o
Oblique head: bases of the second and the third metacarpals and the
capitate bones
Insertion: medial side of the base of the proximal phalanx of the thumb
innervation: deep branch of the ulnar nerve
Action: adducts the thumb
hypothenar muscles
1.
abductor digiti minimi
2.
flexor digiti minimi brevis
3.
opponens digiti minimi
abductor digiti minimi
Origin: (pisiform)
Insertion: Proximal phalanx of little finger
action: abducts pinky
innervation: ulnar nerve
Flexor digiti minimi brevis
Origin: Flexor retinaculum and hook of hamate
Insertion: Medial side of proximal phalanx of 5th finger
Action: Flexion of proximal phalanx of pinky
Innervation: Ulnar Nerve
Opponenes digiti minimi
Origin- Hook of hamate and flexor retinaculum
Insertion- medial border of pinky
Innervation- Ulnar nerve
Main Action- bringing pinky into opposition with thumb
palmar muscles
1.
Lumbricals
2.
Palmar Interossei
3.
Dorsal Interossei
Palmar Interossei
Origin: metacarpals
Insertion: proximal phalanx
Innervation: Ulnar nerve
Action: ADDUCTION
Dorsal Interossei
Origin: Metacarpals
Insertion: Proximal phalanx
Innervation: ulnar nerve
Action: Abduct finger
lumbricals
Origin: tendon of flexor digitorum profundus
Insertion: extensor expansion on posterior
Innervation:
o
1, 2, = median
o
3,4, = ulnar
Action: flex metacarpophalangeal joints, extend interphalangeal joints
innervation of the hand
1/2 LOAF = median
(4,3 of lumbricals, opponenes pollicis, adductor pollicis brevis, flexor pollicis brevis )
everything else = ulnar
?
Week 4- Lower Limb, Thigh & Glute
3 compartments of the thigh
anterior - 7
medial - 5
posterior - 3 glute, 6 lateral roatator and 3 hamstring
pelvic girdle
the hip bones (2), sacrum, and coccyx
Connects the lower limbs to the axial skeleton + spine
Less range of movement than shoulder and far more stable
childhood hip development
3 hip bones (ileum, pubis, and ischium) which later fuse in adulthood
Hip bones fuse anteriorly to each other
Fuse posteriorly at sacrum + vertebral column
Pelvis
femur anatomy:
protruding part of hip that you feel
anterior superior iliac spine
if you break a hip where does it ususally occur
neck of the femur
Joint:
the point where two bones come together
vary greatly in structure and function:
the structure of the joint determines the degree, range and direction of
movement
3 types of joints
1.
Fibrous
2.
Cartilaginous
3.
Synovial
fibrous joints
immovable (synathroses)
o
connected by fibrous tissue
o
i.e. tibiofibular joint
cartilaginous joints
slightly movable (amphiarthroses)
hylaine cartilage or fibrocartilage
o
i.e. intervertebral discs
synovial joints
freely movable (diarthroses)
appendicular skeleton
components of synovial joints:
articular cartilage (lines the bones)
joint cavity w synovial fluid in it
articular cavity (outer fibrous + inner synovial membrane)
reinforcing ligaments
nerves and vessels
3 movements of synovial joints
1.
gliding
2.
angular (extension, adduction, circumduction)
3.
rotation
types of synovial joints
plane: patella + femur
hinge: elbow
pivot: radio-ulnar
condyloid: wrist
saddle: metacarpal of thumb
ball and socket : hip
ball and socket joint
Spherical head of one bone fits into round socket of another
Multiaxial joint
hip joint
A ball and socket synovial joint with more limited movement
It has a deeper ball and socket (compared to shoulder) with greater stability,
this allows for the transfer of the weight of the upper body to the lower limbs
Femur fits into the acetabulum
Labrum (cartilage) really anchors the femur into the acetabulum
hip ligaments
iliofemoral (strongest in the body)
pubofemoral, ischiofemoral
attach the femur to the pelvis and stabilize
ligament of the head of the femur
has no functional role
lumbar plexus
1.
L1-L4
a.
from ventral rami
b.
located within psoas major muscle
c.
main branches innervate anterior thigh via femoral and obturator
nerves
2.
L2-L4 (anterior division)
a.
innervates adductor muscles and cutaneous region of inner thigh
b.
femoral nerve
3.
L2-L4 (posterior division)
a.
lies deep to inguinal canal
b.
Innervates: quadriceps and skin of anterior thigh and knee down
Muscles of the anterior thigh
1.
iliopsoas m.
2.
quadriceps (4)
3.
sartorius m.
4.
tensor fasciae latae
quadricep muscles
1.
rectus femoris
2.
vastus lateralis
3.
vastus medialis
4.
vastus intermedius
5.
Iliopsoas
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a.
a compound muscle composed of psoas and iliacus
psoas and iliacus
Origin:
o
psoas: transverse processes of T12 - L5 vertebrae
o
iliacus: iliac fossa and ala of sacrum
Insertion: lesser trochanter via iliopsoas tendon
Action: thigh and trunk flexion
innervation: femoral nerve
Sartorius
Origin: Anterior superior iliac spine
Insertion: medial aspect of knee and medial aspect of tibia
Innervation: femoral nerve
Action: Flexion, abduction, and lateral rotation of the hip, weak flexion of the
knee
longest muscle of the body, crosses both hip and knee
rectus femoris
Origin: anterior inferior iliac spine, superior margin of acetabulum
Insertion: patella and tibial tuberosity via patellar tendon
Innervation: femoral nerve
Action: knee extension; hip flexion
vastus lateralis
Origin: Greater trochanter, Intertrochanteric line, and Linea aspera of the
Femur
Insertion: patella and tibial tuberoscity via patellar tendon
Innervation: femoral nerve
Action: Extends knee
vastus medialis
Origin: inea aspera, supracondylar line, intertrochanteric line
Insertion: patella and tibial tuberoscity via patellar tendon
Action: extends knee and stabilizes patella
innervation: femoral nerve
vastus intermedius
Origin: antero/ lateral femur
Insertion: patella and tibial tuberoscity via patellar tendon
Innervation: femoral nerve
Action: Extension of knee joint
medial thigh superficial muscles
1.
pectinueus
2.
adductor longus
3.
gracilis
Pectineus
Origin: pectineal line of pubis
insertion: lesser trochanter to linea aspera on posterior femur
action: adduct, flex and medially rotates thigh
innervation: femoral (sometimes obturator)
adductor longus
Origin: pubis
Insertion: Linea aspera of femur
Action: Adduction, flexion, and medial rotation at hip
innervation: obturator nerve
gracilis
origin: inferior ramus and body of pubis and ischial ramus
insertion: medial surface of tibia
action: adducts thigh; flexes and medially rotates leg
innervation: obturator nerve
Deep medial thigh muscles
1.
adductor brevis
2.
adductor magnus
adductor brevis
Origin: inferior ramus and body of pubis
Insertion: linea aspera
Action: adducts and medialy rotates thigh
Innervation: obturator nerve
adductor magnus
Origin: ischial and pubic rami, ischial tuberoscity
Insertion: Linea aspera of the femur, supracondylar line, adductor tubercle of
femur
Action:
o
anterior: Adducts, medial rotation and flexion
o
posterior: thigh extension
innervation: obturator nerve and sciatic nerve
sacral plexus
from spinal nerves L4-S4
directly behind the lumbar plexus
1/2 of the branches serve buttocks and lower limb
sciatic nerve
largest and most important nerve for the lower limb
divides into tibial and common fibular nerve
common fibular nerve
supplies lateral and anterior lower leg
tibial nerve
posterior lower leg
divides from sciatic nerve at palpatile fossa (back of knee) into the tibial
nerve
sciatica
pain tingling and numbness caused by irritation of the nerve routes leading to
the sciatic nerve
most common causes: herniated disk or narrowing of spinal canal
symptoms made worse from prolonged standing/sitting
relieved through extension of spinal cord or drugs
Muscles of the butt
1.
gluteus maximum (superficial)
2.
gluteus medius (middle)
3.
gluteus minimus (deep)
gluteus maximus
Origin: dorsal illium, sacrum and coccyx
Insertion Gluteal tuberosity of the femur and iliotibial tract
Innervation: Inferior gluteal nerve
Action: lateral rotation, extension of the thigh, abducts
gluteus medius
Origin: between ant. and post. gluteal lines on lateral illium
Insertion: greater trochanter of femur
Action: abducts and medially rotates thigh, steadies pelvis during walking
innervation: superior gluteal nerve
gluteus minimus
Origin between ant. and post. gluteal lines on external illium
Insertion Greater trochanter of the femur
Action: abducts and medially rotates thigh, steadies pelvis during walking
innervation: superior gluteal nerve
superficial hamstring muscles
1.
biceps femoris
2.
semitendinosus
biceps femoris
Origin:
o
long head: ischial tuberosity and linea aspera
o
short head: femur
Insertion: head of the fibula and lateral tibial condyle
Innervation:
o
long head: tibial nerve
o
short head: common fibular nerve
Actions: flexes knee joint, extends thigh, lateral rotation of leg
Semitendenosus
origin: ischial tuberosity
insertion: medial condyle of tibia to lateral condyle (a hook)
innervation: tibial branch (sciatic)
action: extends thigh, flex knee, medially rotates leg
deep muscles of hamstring
1.
semimembranosus
Semimembranosus
Origin: ischial tuberoscity
Insertion: upper tibial shaft
Action: Flexion of knee, extension of the hip joint, medially rotates leg
innervation: tibial branch (sciatic)
iliotibial band
thickened portion of the fascia lata
extends as a tendonous band from the iliac crest to the knee
controlled by the tensor fascia lata (when contracted very taut and steadies
the thigh)
iliotibial band syndrome
an overuse injury caused by excessive friction of the lower end of the band
against lateral femoral condyle
common in runners
makes walking and running painful "leg"
Refers to the lower limb ONLY
composed of tibia and fibula (more fragile)
?
Week 5- Knee, Leg, Foot & Nervous System
pt.2
tibia and fibula
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tibia with big toe - medial mallolus
fibula - lateral malleolus
intercondylar iminence
tibial tuberoscity
anterior crest
connected via interosseus membrane
components of the foot
1.
tarsus
2.
Metatarsus
3.
phalanges
function of the foot
support the weight of the body
act as a lever to propel the body forward during locomotion
tarsus
posterior foot comprised of seven bones
1.
alcaneus
2.
Talus
3.
Cuboid
4.
Navicular
5.
medial lateral and middle cuneiforms
ankle joint
tibia and fibula articulate directly with the talus
talus then transmits the weight to the calcaneus (heel)
characteristics of a typical synovial joint
articular cartilage
articular capsule (fibrous and synovial)
synovial fluid
articular disc
intracapsular and extracapsular ligaments
role of the patella
a sesamoid found in most tetrapods
increases the distance between the quads and the knee joint = increase in
moment arm
lower limb uses more rotary torque than the elbow
knee joint
modified hinge (femoro-tibial)
plane (patella-femur)
bi-condyloids (4 from tibia and femur)
lateral and medial meniscus role
cartilage that act as a cushion and distribute the weight and support the joint
extracapsular knee ligaments
lateral and medial collateral ligaments (LCL, MCL)
o
prevent side to side movement
intracapsular ligaments of knee
anterior cruciate ligament (ACL)
o
prevent forward movement of tibia
posterior cruciate ligament (PCL)
prevents posterior movement of tibia
ACL and PCL during knee extension become taut and lock the knee
ligaments on the patella
top: tendon of quadriceps femoris muscle
bottom: patellar ligament
flanked on both sides by the lateral and medial patellar retinaculum
posterior ligaments of knee
popliteal ligaments:
oblique and acruate
blow to the side of knee injury
can seperate femur and tibia medially
= damage to tibial collateral ligament, medial meniscus, and ACL
superficial muscles of the lower leg
1.
gastrocnemius
2.
Plantaris
3.
soleus
Gastrocnemius
Origin: 2 heads from lateral and medial condyles of femur
Insertion: calcaneus (achillies tendon)
Action: plantar flexion, knee extension
innervation: tibial nerve
Plantaris:
little guy
Origin: posterior femur above lateral condyle
Insertion: calcaneous tendon
Action: Plantar flexes foot and flexes knee
Antagonist Tibialis anterior muscle
soleus
Origin: superior tibia, fibula and interosseus membrane
Insertion calcaneous tendon
Innervation: tibial nerve
Action: plantar flexion (MAIN GUY)
deep lower leg muscles
1.
popliteus
2.
flexor digitorum longus (FDL)
3.
flexor halllocis longus (FHL)
4.
tibialis posterior
Popliteus
Origin: lateral condyle of femur and lateral meniscus
Insertion: proximal tibia
Innervation: Tibial nerve
Action: flexes and medially rotates lef to unlock from full extension
flexor digitorum longus
Origin: Posterior tibia
Insertion: behind medial malleolus into Distal phalanges of toes 2-5
Action: Flex toes; plantar flexes and inverts foot, grips the ground
innervation: tibial nerve
flexor hallucis longus
origin: middle fibula and interosseus membrane
insertion: distal phalanx of big toe
action: flexes big toe, plantar flexion, inverts food, "push off" during walking
innervation: tibial nerve
tibialis posterior
Origin: Tibia and fibula
Insertion: behind medial malleolus and under arch of foot to metatarsals 2-4
Innervation: Tibial nerve
Action: inversion of the foot (MAIN) plantar flexion
organization around medial malleolus-
TOM dick and harry
lateral components of leg
1.
fibularis longus
2.
fibularis brevis
fibularis longus
origin: lateral fibula
insertion: under the foot to medial cuneiform and 1st metatarsal
action: plantar flexes and everts foot
innervation: superficial fibular nerve
fibularis brevis
Origin: fibula
Insertion: behind lateral malleolus to proximal end of 5th metatarsal
action: eversion and plantar flexion
innervation: superficial fibular nerve
anterior compartment of leg
1.
tibialis anterior
2.
extensor hallucis longus
3.
extensor digitorum longus
tibialis anterior
Origin: lateral condyle and upper tibia, interosseus membrane
Insertion: medial cuneiform and 1st metatarsal
Action: dorsiflexes and inverts foot
innervation: deep fibular
extensor digitorum longus
Origin: lateral condyle of tibia, top of fibula and interosseus membrane
Insertion: middle and distal phalanges of toes 2-5
Innervation: deep fibular nerve
Action: main toe extendor and dorsiflexion of foot
extensor hallucis longus
Origin: fibula and the interosseous membrane
Insertion: distal phalanx of the big toe
Innervation: deep fibular nerve
Action: Extends the big toe, dorsiflexion of foot
ganglia
clusters of cell bodies in the PNS
somatic motor system
one motor neuron
Voluntary receptors (skeletal muscle)
autonomic nervous system
two motor neurons
involuntary effectors: smooth and cardiac muscle, glandular tissue
sympathetic NS (origin, neurotransmitters, ganglia and neuron description)
fight or flight
origin: thoracolumnar (T1-L2) - lateral horns of spinal cord
short pre-ganglion, long post-ganglion
achetylcholine (onto post-g) and norepinephrine (onto effectors)
o
EXCEPT: sweat glands and peropheral BV get Ach
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ganglia: sympathetic trunk or collateral ganglia
parasympathetic nervous system (origin, neurotransmitters, ganglia and
neuron description)
rest and digest
origin: craniosacral
o
brainstem nuclei and sacral S2-S4
long pre-ganglion, short post ganglion
achetylcholine
ganglia: intramural (within the walls of the organ)
which organs get no PSYM input
skin and adrenal glands
actions of SYM
increased HR and BP
dilated pupils
decreased digestion
bronchiole dilation
BV dilation
actions of PSYM
decreased HR and BP
increased digestion
pupil constriction
bronchiole constriction
pathway of sympathetic trunk
lateral horns of spinal cord via ventral root
mixed spinal nerve
white rami communicans (myelinated)
sympathetic chain
3 possible pathways:
-synapse at that level
-travel up or down then synapse
- travel through chain, exit via splanchic nerves (internal organs) and synapse at
collateral ganglia
exit via grey rami communicans
ventral ramus
sympathetic pathway to periphery
short pre-ganglion synapse with adrenal glands (Ach)
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stimulate chromaffin cells
release of NE onto blood vessels
a systemic sympathetic response to effectors
sympathetic trunk
paravertebral chain
paired
extends down the length of vertebral column
collateral ganglia
pre-vertebral (anterior to vertebral column, usually with BV)
unpaired
exists in abdomen
PSYM pathway of head (cranial nerves)
ciliary ganglion - smooth muscle of eye
pterygopalatine ganglion - nasal mucosa and lacrimal glands
✨
Week 6- Heart, Coronary & Pulmonary
System
superior left heart
o
2nd costal cartilage, lateral to sternum
superior right of heart
o
3rd costal cartilage at sternum
inferior right of heart
o
6th costal cartilage, lateral to sternum
inferior left of heart
o
5th intercostal space at midclavicular line
Main structures of the heart
Superior and inferior vena cava, RA, RV, Pulmonary trunk, LA, LV,
Layers of pericardium
external: fibrous
internal: smooth serous
parietal serous
visceral serous (aka epicardium)
external fibrous layer
dense irregular connective tissue
stabilizes heart
prevents overfilling of blood
connects to the pericardial sac superiorly (via roots of great vessels
connects to diaphragm inferiorly
smooth serous layer
parietal serous: lines external fibrous layer
visceral serious (epicardium)
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2 layers are separated by pericardial cavity
where are the parietal and visceral layers continuous?
At the root of the great vessels
Where is the apex of the heart
Bottom of LV
Features of the right atrium
Crista Terminalis: separate rough and smooth muscles
Pecinate Muscles: rough wall
3 Openings: SVC, IVC, Coronary sinus
Fossa ovalis: remnant of foramen ovale
Right Auricle
Features of right ventricle
Interventricular septum
Tricuspid valve
Papillary muscles
Chordae tendinae
Pulmonary semilunar valve - 3 semilunar cusps
Trabeculae Carnae: roughened projections from walls
Left atrium and ventricle features
Opening of pulmonary veins
Mitral valve leaflet (bicuspid)
Chorade tenidnae
Papillary Muscle
Interventricular septum
Purpose of valves in the heart
prevent backflow of blood
prevents overdilation of valve opening
point of attachment of cardiac muscle
block electrical impulses from atria to ventricles
4 valves in the heart
2 atrioventricular valves
2 semilunar valves
Respiratory system: organ system that carries out gas exchange - supply body with
oxygen and carbon dioxide. In order to do this, respiration needs to occur
1.
Pulmonary ventilation (breathing) - moving air in and out of the lungs
2.
External respiration - gas exchange between blood and air. Oxygen diffuses
into blood, carbon
dioxide diffuses into the air
3.
Transport of gases - the gases must move from lungs to cells of the body
(accomplished by the
circulatory system)
4.
Internal respiration - gas exchange between blood and tissue cells
Because the respiratory system moves air in and out of the body, it is also involved
in the sense of smell and speech.
Upper respiratory tract: nose, nasal cavity, paranasal sinuses, pharynx and larynx
Lower respiratory tract: trachea, bronchi (and their branches), lungs, alveoli
Conducting zone - carry air to the sites of gas exchange. Filter, humidify and warm
incoming air. Respiratory zone - site of gas exchange in the lungs.
?
Week 7- Respiratory System 1
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The Nose and Paranasal Sinuses
Functions of the nose:
Provides an airway for respiration
Moistens and warms incoming air
Filters incoming air
Mucus traps bacteria and particulates
Serves as a resonating chamber for speech (think about nasally voices)
Houses olfactory receptors
The nose is divided into the external nose and the internal nasal cavity; entrance -
naris (nostrils), Exit - chonae
Surface Anatomy:
frontal belly, root and bridge of nose, ala, apex of nose,
naris, and philtrum
. Skeletal
Framework:
frontal, nasal, palatine, maxilla, ethmoid and vomer bones;
septal, nasal, minor and major alar cartilage
.
The nasal cavity is divided into two halves with the
nasal septum
(ethmoid and
vomer and septal cartilage) in the middle (formed by the perpendicular plate of the
ethmoid bone, the vomer and a septal cartilage). The nasal septum has lots of blood
vessels which all come together at
Kiesselbach’s area
- a typical location of
nosebleeds (epistaxis)
The lateral wall is made of the nasal, maxilla, palatine and sphenoid bones
Chonchae
force air through smaller channels and increase surface area through
which air contacts respiratory epithelium (mucus). There is the
inferior nasal
concha
, and the ethmoid bone (which is comprised of the
superior nasal concha
and middle nasal concha
Superior nasal cavity is lined with the olfactory epithelium. This is the only area for
smell in the cavity. The rest of the nasal cavity is lined with respiratory epithelium
(mucus-producing)
Underneath each concha there is a superior, middle and inferior meatus that
structures can connect to. The nasal cavity connects to the paranasal sinuses, the
eyes (nasolacrimal ducts), the oral cavity (pharynx), and the ears (auditory /
Eustachian tube). The sinuses are air-filled cavities in the bones. Infection and
inflammation of the nasal cavity (rhinitis) and the paranasal sinuses (sinusitis)
causes swelling and buildup of mucus.
The respiratory mucosa lines the nasal cavity and paranasal sinuses. Its epithelium
is covered with a sheet of mucus that filters dust particles and moistens inhaled air.
Its lamina propria contains glands that contribute to the mucus sheet and blood
vessels that warm the air.
22.1b: The Pharynx
The pharynx starts at the posterior of the nasal cavity and extends to the
esophagus. It is divided into three segments;
Nasopharynx
(superior border - sphenoid, inferior border - soft palate)
Oropharynx
(superior border - soft palate, inferior border - epiglottis)
Laryngopharynx
(superior border - epiglottis, inferior border - inferior end of
cricoid cartilage)
22.1c: The Larynx
Forms the upper windpipe. Responsible for keeping food out of the respiratory tract,
is an air passageway and acts as the voice box. Key features of the larynx are the
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laryngeal cartilages. Form a skeleton that alters the length and tightness of the
vocal cords.
Four main cartilages
1.
Epiglottis
: folds over larynx during swallowing to prevent food from entering
the respiratory system.
2.
Thyroid
: large in the front and side but doesn't go all the way around (forms
adam’s apple). The groove above Adam's apple is the superior thyroid notch.
Posteriorly there are extensions called horns. Articulates with the cricoid
cartilage inferiorly.
3.
Cricoid
: only cartilage that goes completely around the windpipe. Ring is
anterior, the signet is posterior. Connects with thyroid cartilage via
cricothyroid ligament. Articulates with thyroid and arytenoid cartilages
4.
Arytenoids
: pyramid-shaped cartilages on top of cricoid that attach to vocal
cords. Rest behind thyroid cartilage and on top of cricoid cartilage. Many
muscles attach here that allow movement of the vocal cords.
Vestibular Ligaments
- Known as false vocal cords. They are more lateral so air typically misses
them.
- Attach to arytenoid cartilage
- Help epiglottis close off larynx during swallowing
Vocal Ligaments
- True vocal cords
- Attach to vocal process of arytenoid cartilages to back wall of thyroid
cartilage
- Sound is made when air passes over vocal folds.
Movement of vocal folds
- Speech volume and pitched is completed by regulating the space and thickness of
vocal ligaments
22.1d: The Trachea
- 16-20 C-shaped rings of hyaline cartilage.
- The open posterior parts of the cartilage rings (in front of esophagus),
contain the
trachealis
muscle and soft connective tissue.
- The
carina
(a ridge on the internal aspect of the last tracheal cartilage)
marks the point where the
trachea branches into the two main (primary) bronchi. Mucosa lines the
carina.
- Typical histology with adventitia instead of serosa.
22.1e: The Bronchial Tree
The two main bronchi are branches of the trachea in the mediastinum. The
right main bronchus is wider, shorter and more vertical than the left (inhaled
objects are more likely to lodge here.
Trachea
→
Primary (main) bronchi
→
Secondary (lobar) bronchi
[superior, middle (R only), and inferior]
→
Tertiary (segmental) bronchi
[each lung has ~10 that supplies a bronchopulmonary segment. We can
resect a segment w/o affecting other segments]
→
~conducting
bronchioles~
→
terminal bronchioles
→
Respiratory bronchioles
→
Alveoli
22.1f: The Lungs and Pleurae
Pyramid-shaped: Apex (rounded superior tip) and Base (concave inferior
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surface)
3 Surfaces: Costal, diaphragmatic, mediastinal
3 Borders: Anterior, posterior, inferior
Right (larger): 3 lobes (superior, middle, inferior); oblique and horizontal
fissure
Left (smaller): 2 lobes (superior and inferior); has cardiac notch; oblique
fissure
Hilum
: entrance and exit of vessels (arteries more superior than veins) and
nerves; where parietal (adjacent to abdominal walls) and visceral (covering
lungs) pleura meet.
Pleurae
: fluid-filled (serous) sacs that surround each lung.
Pleural Cavity
: space between the two pleura; filled with pleural fluid that
allows lungs to glide. Pressure in the cavity is always lower than atm
pressure.
Pneumothorax
(collapsed lung): If the pleural cavities are punctured, air
and liquid easily enter the pleura because of its low pressure. Causes a
pressure increase, leads to the lung collapsing
Emboli:
The capillaries are so small that they are prone to clots from
insoluble material in blood
22.2a: The Mechanism of Ventilation
Breathing or pulmonary ventilation consists of two phases: inspiration (inhalation)
and expiration (exhalation)
External Respiration
: gases move from high to low pressure.
Type 1 alveolar
cells
form the alveolar wall.
Type 2 alveolar cells
produce surfactant.
Macrophages
protect from infection and dust. Breathing Mechanics:
Air moves in and out of the lungs based on the relative pressure compared to
atmospheric pressure (low pressure in lungs = inspiration; high pressure in lungs =
expiration). Pressure in lungs is controlled by altering the volume of the thoracic
cavity (contracting the diaphragm and extra help from other breathing muscles help
this to occur).
The diaphragm is the principle breathing muscle. Its peripheral muscle fibers attach
to the sternum, ribs and vertebrae. Contraction of the diaphragm (flattening of the
parachute) increases the volume of the thoracic cavity (inspiration). Relaxation of
the diaphragm (resumes parachute shape) decreases the volume of the thoracic
cavity (expiration).
22.2b: Neural Control of Ventilation
- Neurons from the medullary respiratory center in the medulla oblongata
stimulate the phrenic nerve (to diaphragm) and intercostal nerves (to
intercostal muscles)
- Chemoreceptors respond to changes in blood and can send signals to help
blood gasses return to normal levels. Information is sent via the vagus nerve
and glossopharyngeal nerve.
- Respiratory muscles are under voluntary control but the respiratory centre
sets a basic respiratory rhythm
Autonomic Control of the Airways:
Smooth muscle surrounding the bronchioles controls how much air flows into
the alveoli. Parasympathetic: smooth muscle contraction (bronchial
constriction, mucus secretion) Sympathetic: smooth muscle relaxation
(bronchial dilation)
Asthma
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- Allergic inflammatory response to irritants in the air, stress, etc. Symptoms
include coughing, wheezing and shortness of breath. Use bronchodilators and
glucocorticoids to treat.
COPD
- Category of disorders in which the flow of air in or out of the lungs is
difficult or obstructed. Mostly refers to chronic bronchitis or emphysema
(usually occurring together)
- Bronchitis: irritants lead to prolonged secretions of mucosa, inflammation
and fibrosis of the mucosa. Obstructs airways and houses bacteria and
viruses. Results in low blood oxygenation which results in cyanosis and other
signs of heart failure (including edema)
- Emphysema: permanent enlargement of the alveoli. Chronic inflammation
leads to fibrosis and the lungs become less elastic. Breathing becomes
difficult and exhausting. Typically creates a barrel chest. Treated with
bronchodilators and anti-inflammatory drugs
?
Week 8+9- Digestive System
23.1b: The Peritoneal Cavity and Peritoneum
The digestive organs all develop surrounded by the peritoneum and the peritoneal
cavity (allows organs to glide over one another).
Peritonitis
: inflammation and infection of the peritoneum. Can arise from a
piercing wound to the abdomen, from a perforating ulcer that leaks stomach juices
into the peritoneal cavity.
Mesenteries
: A mesentery is a double layer of peritoneum (a sheet of two serous
membranes fused together) that extends from the body wall to the digestive
organs. Mesenteries hold organs in place, store fat (limit spread of infections), and
provide a route for circulatory vessels.
23.1c: Digestive processes
1.
Ingestion
is the taking of food into the mouth
2.
Propulsion
is the movement of food through the alimentary canal. It
includes swallowing, which
is initiated voluntarily and peristalsis, an involuntary process. Peristalsis
involves alternate waves of contraction and relaxation of musculature in the
organ walls. Its net effect is to squeeze food from one organ to the next but
some mixing occurs too.
3.
Mechanical breakdown
physically prepares food for digestion by enzymes
by breaking it down into smaller pieces. Mechanical processes include
chewing, the churning of food in the stomach, and segmentation.
4.
Digestion
is a series of steps in which food molecules are broken into their
chemical building blocks. Glands in the GI tract and accessory organs
produce enzymes and other substances and secrete them into the lumen of
the alimentary canal.
5.
Absorption
is the movement of digested products from the lumen of the
alimentary canal into the blood and lymph located in the wall of the canal.
6.
Defecation
is the elimination of indigestible substances from the body as
feces.
23.2b: Smooth Muscle
Most smooth muscle is found in the walls of visceral organs. There are six major
locations: the iris, and the walls of the circulatory vessels, respiratory tubes,
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digestive tubes, urinary organs, and reproductive organs. Most often there are two
sheets, a longitudinal layer and a circular layer.
Smooth muscle is innervated by the autonomic (automatic) nervous system. Does
not always require a nervous signal, can be stimulated by stretching or hormones.
23.2c: The Mouth and Associated Organs
The mouth is a mucosa-lined cavity whose boundaries are; Anterior Border: Lips
Superior Border: Hard Palate and Soft Palate
Posterior Border: Fauces
Lateral Borders: Cheeks
Inferior Border: Tongue
Its opening is the oral orifice. Posteriorly, the mouth borders the oropharynx.
The mouth is divided into the oral
vestibule
(slit between the teeth and
cheeks/lips) and the
oral cavity proper
(the region internal to the teeth)
The
labial frenulum
is a median fold that connects the internal aspect of each lip
to the gum
The Palate
The palate has two distinct parts: the hard palate and the soft palate. The soft
palate is a mobile flap that rises to close off the nasopharynx during swallowing.
Dipping inferiorly from the free edge of the soft palate is the
uvula
(don’t really
know what uvula does).
The soft palate is anchored to the tongue by the
palatoglossal arches
and to the
wall of the oropharynx by the
palatopharyngeal arches
The Tongue
Motor Innervation of the Tongue
The
hypoglossal nerve
innervates most intrinsic and extrinsic muscles of the
tongue. The intrinsic muscles change the shape of the tongue, whereas the extrinsic
muscles extend the tongue from bones of the skull and the hyoid bone. These
intrinsic muscles allow the tongue to protrude, retract, etc. There are four pairs of
extrinsic muscles:
Styloglossus
(tongue to styloid)
Genioglossus
(tongue to chin)
Hyoglossus
(tongue to hyoid)
Palatoglossus
(tongue to palatoglossal arch)
Sensory Innervation of the Tongue
-
Facial nerve
(for taste)
-
Trigeminal nerve
(for sensation)
-
Glossopharyngeal nerve
(sensation and taste for posterior 1
⁄
3 of the
tongue (lingual tonsil
area))
The
lingual frenulum
is a fold on the under surface of the tongue that
secures the tongue to the floor of the mouth.
The dorsal surface of the tongue is covered with three major types of
projections of the mucosa
The
foliate
are like serrated edges on the side of your tongue.
The
filiform papillae
roughen the tongue and allow it to grasp and
manipulate food (can’t really see)
The
fungiform papillae
are scattered widely. Taste buds occur on the tops
of these papillae.
10-12
vallate papillae
line up in a v-shaped row bordering the posterior
third of the tongue (terminal sulcus). Taste buds are on the sides of these
papillae.
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The posterior third of the tongue, which lies in the oropharynx, is covered
with bumpy
lingual tonsil
.
The Salivary Glands
Produce saliva (mixture of water, ions, mucus and enzymes) that has many
functions such as moistening the mouth, dissolving food chemicals, wets food
and binds the food together. Its enzymes begin the digestion of
carbohydrates and fats. Contains bicarbonate buffer that neutralizes the
acids in the mouth. Minor (intrinsic) salivary glands within the mucosa of the
tongue, palates, lips and cheeks keep the mouth moist at all times. Major
(extrinsic) salivary glands (lie external to the mouth but connect via ducts)
secrete saliva only during eating or anticipation of eating. These glands are
the
parotid, submandibular and sublingual glands
.
The largest major gland is the
parotid
(par = near; otid = the ear). The
parotid duct penetrates the muscle of the cheek and opens into the mouth
lateral to the second upper molar. Secretion is stimulated by the
glossopharyngeal nerve
.
The
submandibular gland
lies just anterior to the mandible bone. Its ducts
open in the floor of the mouth just lateral to the tongue’s lingual frenulum.
The
sublingual gland
lies in the floor of the oral cavity, inferior to the
tongue. Its 10-12 ducts open into the mouth directly superior to the gland.
Both the sublingual and submandibular glands are innervated by the
facial
nerve
.
Sialography
: radiographic examination of the salivary glands. Evaluate the
functional integrity of the salivary glands.
23.2d: The Pharynx
The pharynx is a muscular tube that runs from the back of the nasal to the
esophagus, carrying air and food to respiratory and digestive structures. It is divided
into 3 portions:
nasopharynx, oropharynx and laryngopharynx
.
Swallowed food passes posteriorly into the oropharynx and then the
laryngopharynx. The muscles of the neck and pharynx contract in sequence to
complete the swallowing process.
1.
The
suprahyoid muscles
lift the larynx superiorly and anteriorly to position
it beneath the protective flap of the epiglottis, thus closing the airway so food
is not inhaled into the lungs.
2.
The three
pharyngeal constrictor muscles - superior, middle and
inferior
- encircle the pharynx and partially overlap each other. They
squeeze the bolus into the esophagus. The pharyngeal muscles are skeletal
muscles innervated by somatic (voluntary) neurons carried in the
vagus
nerve
.
3.
The infrahyoid muscles pull the hyoid bone and larynx inferiorly returning
them to their original position.
Tonsils: 4 sets. Accumulation of lymphoid nodules. First line of defense.
Palatine
tonsils
: most often removed
Lingual tonsils
: base of tongue
Tubal tonsils
: located around Eustachian tube
Pharyngeal tonsils
: aka adenoids
Swallowing:
1.
Oral Phase (mouth to oropharynx; forms food bolus; consists of chewing and
mastication)
Voluntary. Tongue elevates and pushes food bolus again the hard palate and
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backward to the oropharynx. Intrinsic and extrinsic muscles of the tongue and
cheek muscles push the bolus backwards until it reaches the palatoglossal
and palatopharyngeal arches.
2.
Pharyngeal Stage (oropharynx to esophagus; nasal cavity and larynx closed
off; contraction of the pharynx)
Involuntary. Blocks 3 cavities and contracts the pharynx to force bolus into
the esophagus.
The oral cavity is blocked by tongue elevation
The nasal cavity is blocked by elevation of the soft palate. Three muscles;
tensor veli palatini
(tenses soft palate),
levator veli palatini
(elevates
soft palate),
palatopharyngeus
(tenses soft palate - helps close off
nasopharynx)
The larynx is blocked by elevation of the larynx which causes the epiglottis to
fold over the laryngeal inlet. The suprahyoid muscles lift the larynx superiorly
and anteriorly (
mylohyoid, stylohyoid, digastric muscles
)
3.
Esophageal Stage (esophagus to stomach; completes swallowing process)
Involuntary. Contraction of skeletal muscle in the upper part of the
esophagus. Peristalsis. As swallowing ends, the infrahyoid muscles pull the
hyoid bone and larynx inferiorly and return them to their original position.
4.
Contraction of the Pharynx
Pharyngeal constrictor muscles encircle the pharynx and partially overlap
each other. They contract sequentially.
Superior pharyngeal constrictor
→
Middle Pharyngeal constrictor
→
Inferior pharyngeal constrictor.
Peristalsis
: Adjacent segments of GI tract contract and relax. Occurs in the
esophagus, stomach, small and large intestine.
Segmentation
: Non adjacent segments of GI tract alternately contract and relax,
moving food forward then backward. Occurs in the small intestine.
Histology: The walls of the GI tract have the same four tissue layers
1.
Mucosa
: directly surrounding lumen. Absorption, secretions, etc. Consists of
three sublayers.
1.
Lining epithelium - highly differentiated along regions of the GI tract.
Responsible for absorbing nutrients and secreting mucus.
2.
Lamina propria - connective tissue whose capillaries nourish the lining
epithelium and absorb digested nutrients.
3.
Muscularis mucosae - layer of smooth muscle that produces local
movements of the mucosa
2.
Submucosa
: blood and nervous supply. The many elastic fibers allow the
alimentary canal to return to its original shape after food material passes
through it. Where feelings of distress come from.
3.
Muscularis Externa
: facilitate peristalsis and segmentation. Consists of two
layers.
1.
Inner circular layer - fibers orient around the circumference of the
canal. Squeezes the gut
tube. In some places the layer thickens and forms sphincters (cardiac
and pyloric, for
example)
2.
Outer longitudinal layer - fibers orient along the length of the canal.
Shortens the gut
tube. Great for peristalsis and segmentation.
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4.
Serosa
: provides slippery surface. It is very thin and as the canal expands
and contracts, the
slippery surface rescues friction against adjacent structures (AKA visceral
peritoneum). Parts of the alimentary canal that are not associated with the
peritoneal cavity lack a serosa and have an
adventitia
as their outer layer.
The esophagus has an adventitia that binds it to surrounding structures.
Retroperitoneal organs have both a serosa and adventitia, the former on the
anterior side facing the peritoneal cavity and the later on the posterior side
embedded in the posterior abdominal wall.
23.2e: The Esophagus
Starts as a continuation of the pharynx in the midneck, descends through the thorax
and passes through the esophageal hiatus in the diaphragm to enter the abdomen.
Joins the stomach at the cardial orifice, where a cardiac sphincter acts to close off
the lumen and prevent regurgitation. Unlike the mouth and pharynx, the esophageal
wall contains all four layers of the alimentary canal: mucosa, submucosa,
muscularis externa and adventitia. Note that the most external layer is the
adventitia, not serosa. This is because the thoracic segment of the esophagus is not
suspended in the peritoneal cavity.
Clinical application:
Hiatal Hernia
In a hiatal hernia, the superior part of the stomach pushes through an enlarged
esophageal hiatus into the thorax following a weakening of the diaphragmatic
muscle fibers around the hiatus. Because of this the acidic stomach juices are
persistently regurgitated, eroding the wall of the esophagus and causing a burning
pain.
Clinical application:
Gastroesophageal Reflux Disease
Regurgitation associated with the hiatal hernia is just one form of GERD. Most cases
are due to abnormal relaxation or weakness of the esophageal sphincter. Symptoms
include heartburn, regurgitation of stomach contents and belching. After continuous
exposure to the acidic stomach contents, the lower esophagus develops ulcers.
23.2f: The Stomach
Temporary storage tank in which the bolus is churned and turned into a paste
(chyme). The stomach also starts the breakdown of proteins (produces pepsin).
Most substances are absorbed in the small intestine, but some are absorbed in the
stomach, including water, electrolytes and some drugs. Food remains in the
stomach for roughly four hours.
The stomach has four major regions:
Cardia
: Encircles the
cardial orifice
and contains the
cardiac sphincter
Fundus
: Part of the stomach that rises above the cardia. Gas bubbles accumulate
here.
Body
: Majority of the stomach
Pyloric Region
: Composed of 2 parts: canal and antrum. Contains
pyloric
sphincter
Two curvatures:
lesser curvature
(sharp and short) and
greater curvature
(long
and soft). The greater and lesser omentum, the mesenteries that connect to the
stomach, are named for their attachment to these curvatures.
The inner surface of the stomach contains
rugae
which are numerous longitudinal
folds of mucosa which flatten as the stomach fills.
Histology:
1.
Mucosa: simple columnar epithelium with mucus glands. Dotted with gastric
pits that open into
tubular gastric glands. In the pyloric and cardiac regions the cells of the
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glands are primarily
mucous cells
. In the fundus and body regions the
gastric glands contain four cell types;
mucous cells
(secrete mucus and
bicarbonate),
chief cells
(secrete pepsinogen and gastric lipase for fat
digestion),
parietal cells
(produce HCL and intrinsic factor), and
enteroendocrine cells
(release hormones into capillaries underlying lamina
propria)
2.
Submucosa: contains blood, lymph and nerves.
3.
Muscularis externa: contains
3
layers. The typical inner circular and outer
longitudinal but also an
innermost oblique.
Arterial Supply:
From the abdominal aorta and celiac trunk, the left gastric artery, common hepatic
artery and splenic artery provide blood to the stomach.
1.
Left Gastric: lesser curvature of stomach
2.
Common Hepatic Artery
1.
Right gastric artery: inferior lesser curvature
2.
Right gastroepiploic artery: greater curvature
3.
Splenic Artery
1.
Left gastroepiploic artery: superior greater curvature
2.
Short gastric artery: fundus
The stomach is innervated by sympathetic fibers (autonomic and fight or flight) that
derive from the
thoracic splanchnic nerves
by way of the celiac plexus, and by
parasympathetic fibers (autonomic and rest/digest) that derive from the
vagus
.
The corresponding veins drain into the portal splenic and superior mesenteric veins.
23.2g: The Small Intestine
The small intestine is the longest part of the alimentary canal and is where almost
all absorption of nutrients occurs. During digestion the small intestine undergoes
segmentation that shuffles the chyme back and forth, maximizing contact with
nutrient-absorbing mucosa. Takes about 3-6 hours to go through the small intestine.
The small intestine has three subdivisions; the duodenum, the jejunum and the
ileum. Jejunum makes up the superior left section whereas the ilium makes up the
inferior right part.
Duodenum:
Direct continuation of pylorus of stomach and ends at
duodenal-jejunal flexure
.
Receives digestive enzymes from the pancreas via the main
pancreatic duct
.
Bile comes from the liver and gallbladder via the
bile duct
The ducts join together to form the
hepatopancreatic ampulla
which opens into
the duodenum at
major duodenal papilla
.
Jejunum and Ileum:
Continue the digestion and absorption process.
The jejunum starts at the
duodenal-jejunal flexure
(top left)
The ileum ends at the
ileo-cecal junction
(bottom right.
The jejunum is more vascular and carries out more absorption. The Ileum is more
lymphoid and has less absorption.
Specializations (to maximize absorption):
1.
Plicae circulares
: circular folds of mucosa and submucosa. Swirl chyme
through the
intestine, slowing movement allowing more time for absorption.
2.
Villi
: finger-like projections of mucosa that increase surface area
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3.
Microvilli
: cover apical surface of enterocytes. Long and densely packed
which amplifies
surface area and contains enzymes that help breakdown nutrients.
Histology:
1.
Mucosa:
1.
arranged in villi and crypts
1.
Enterocytes
: contain microvilli
2.
Goblet cells
: secrete mucus
3.
Enteroendocrine cells
: secrete hormones. Signal gallbladder
to release bile and pancreas to release digestive enzymes and
bicarbonate rich juice
4.
Intestinal Crypt
: contains intestinal stem cells and Paneth cells
2.
Lamina propria has vessels that carry absorbed products or proteins
and
carbohydrates. Lacteals carry absorbed fats.
3.
Muscularis mucosa help keep mucosal layer moving
2.
Submucosa:
1.
In duodenum only: duodenal glands open into intestinal crypts.
Secretes alkaline
mucus that neutralizes acidity of chyme and helps protect mucosa.
2.
In distal jejunum and ileum: huge areas of lymphoid nodules monitor
bacteria in
intestines
3.
Muscularis externa
4.
Serosa
The small intestine is innervated with parasympathetic fibers from the vagus nerve
and sympathetic from the thoracic splanchnic nerves. Both are relayed through the
superior mesenteric (and celiac) plexus.
Arterial supply comes primarily from the superior mesenteric artery. The veins run
parallel to the arteries and typically drain into the superior mesenteric vein. From
there, the nutrient rich blood drains into the hepatic portal vein, which carries it to
the liver.
23.2h: The Large Intestine
The material that reaches the large intestine is largely digested residue that
contains few nutrients. The main function is to absorb water and electrolytes from
the digested mass, resulting in a semi-solid feces. Movement is weak and slow.
Subdivides into the cecum, appendix, colon, rectum and anal canal (the colon is
further divided into the ascending, transverse and descending).
There are three special features of the small intestine.
Teniae coli
are longitudinal strips that are thickenings of the longitudinal layer of
the muscularis externa. They cause the large intestine to pucker into sacs known as
haustra
.
Epiploic appendages
are fat filled pouches of visceral peritoneum that
hang from the intestine. Their significance is unknown.
The Large Intestine: 1. Cecum
a. The large intestine begins with the cecum. The opening is surrounded internally
by the
ileocecal valve
. Receives contents from the ileum.
1.
The appendix is a blind tube that opens into the posteromedial wall of the
cecum. Lots of lymphoid tissue
Clinical Application:
Appendicitis
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Results from a blockage that traps infectious bacteria within its lumen.
Unable to empty its contents, the blocked appendix swells leading to tissue
death and infection. If it ruptures, bacteria and feces are released into the
peritoneum, causing peritonitis.
2.
Colon
1.
Four Parts:
1.
Ascending Colon: connects cecum to transverse colon
2.
Transverse Colon: largest, most superior and most motile part of
large intestine
3.
Descending Colon: non-motile. Connects transverse colon to
sigmoid colon.
4.
Sigmoid Colon: very motile. Connects descending colon to
rectum
2.
Two Flexures:
1.
Hepatic flexure
2.
Splenic flexure
Colon Histology:
1.
Mucosa
o
- Relatively smooth, no plica circulares or villi. Fewer nutrients are
absorbed. Large crypts are present
o
- Colonocytes: absorb water and electrolytes
o
- Goblet Cells: very abundant, secrete mucus to ease passage of feces
2.
Submucosa
3.
Muscularis Externa
- Thin except at the teniae coli
4. Serosa
- Contains the epiploic appendages
Rectum:
- Fixed portion of LI that penetrates pelvic diaphragm. No teniae coli, but has
thick,
well-developed muscles that help promote defecation.
- Internally there are three transverse rectal folds that prevent feces from
being passed along with
gas. Anal Canal:
- Terminal end of the large intestine continues with rectum. Begins at levator ani
and ends at anus. Internally divided by the pectinate line.
Superior to pectinate line:
-
Visceral sensory nerves
; insensitive to pain
- Continuous blood supply with GI tract
-
Anal columns
: longitudinal folds of mucosa
-
Anal valves
: connect adjacent anal columns
-
Anal sinuses
: pockets formed by anal valves. Filled with mucus, which is
released during defecation Inferior to pectinate line:
-
Somatic sensory nerves
; sensitive to pain
- Distinct blood supply from rest of GI tract
The wall of the anal canal contains two sphincter muscles: an
internal anal
sphinctor of smooth muscle and an external sphinctor of skeletal
muscle
. The external sphincter contracts voluntarily to inhibit defecation,
whereas the internal sphincter contracts involuntarily, both to prevent feces
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from leaking.
The rectum is usually empty and the anal sphincters contracted. When feces
are squeezed into the rectum, the stretching of the rectal wall initiates the
defecation response. The sacral spinal cord mediated this and sends
parasympathetic reflux signals to the walls of the sigmoid colon and rectum
to contract and the internal anal sphinctor to relax.
During defecation, the muscles of the rectum contract to expel the feces. This
process is supplemented by an increase in intra-abdominal pressure, and the
levator ani muscle lift the anal canal superiorly.
Blood Supply to Intestines:
Celiac trunk
: stomach, proximal half of duodenum, liver and spleen
Superior mesenteric artery
: distal half of duodenum, jejunum, ileum,
cecum/appendix, ascending colon and 2
⁄
3 of transverse colon
Inferior mesenteric artery
: distalf 1
⁄
3 of transverse colon, descending and
sigmoid colon, rectum and anal canal (above pectinate line, below is supplied
by the inferior rectal artery.
Blood supply from alimentary canal:
Hepatic portal system carries absorbed nutrients from the tract directly to the
liver where it can be detoxified before travelling to the heart. The tributaries
are the
splenic vein
,
superior mesenteric vein and inferior mesenteric
vein
.
The sympathetic innervation is from the superior mesenteric and celiac
ganglia and plexuses, and its parasympathetic comes from the vagus nerve.
The final part of the anal canal, below the pectinate line is innervated by
somatic nerves like the
pudendal nerve
.
Peritoneal Cavity and Peritoneum
The abdominopelvic cavity contains the peritoneum. We see the visceral
peritoneum and parietal peritoneum just like with the lungs.
Mesentery: double layer of peritoneum. Connects intraperitoneal organs with each
other or to the abdominal wall. Ventral and dorsal
Dorsal mesenteries - extend from posterior abdominal wall to alimentary canal
1.
Greater omentum: connects greater curvature of stomach to transverse
colon. Elongated
anteriorly, covers the transverse colon and small intestine like an apron.
2.
Mesentery: supports the jejunum and ileum. Fans inferiorly from posterior
abdominal
wall
3.
Transverse mesocolon: connects transverse colon to posterior abdominal
wall. Fused to
the underside of the greater omentum.
4.
Sigmoid mesocolon: connects the sigmoid colon to the posterior pelvic wall.
Intraperitoneal organs: almost completely surrounded by peritoneum. Organ can
freely move. (stomach, jejunum, ileum, transverse colon, sigmoid colon).
Retroperitoneal organs: organ is behind peritoneum; only partly covered. Fixed
position. (duodenum, pancreas, ascending and descending colon).
Diverticulosis and Diverticulitis
When the diet lacks fiber, contractions of the circular muscle in the colon exert
greater pressures on its wall. This pressure promotes the formation of multiple sacs
(diverticula). The resulting condition is diverticulosis. Typically occurs in the sigmoid
colon. Leads to nothing but dull pain - although it may rupture an artery in the colon
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and produce bleeding. In some diverticulosis cases, patients develop diverticulitis,
in which the inflamed diverticula become infected and may perforate, leaking feces
into the peritoneal cavity.
Peptic Ulcers
Ulcers are craterlike erosions of the mucosa in any region of the alimentary canal
exposed to stomach secretions. Majority occur in the pyloric region (gastric ulcers)
or in the duodenum (duodenal ulcers). Typical symptom is chronic burning 1-3 hours
after a meal. Caused by an infectious acid-resistant bacteria. It binds to the gastric
epithelium and induces oversecretion of acid and inflammation.
Intestinal
Obstruction
Any hindrance to the movement of chyme or feces is an intestinal obstruction. Most
are mechanical - due to hernias or twists, intestinal tumors or adhesions, or foreign
objects lodged in the bowel. Nonmechanical obstruction is due to a halt in
peristalsis. Common symptoms include cramps, vomiting, nausea, and a failure to
pass gas and feces.
Inflammatory Bowel Disease (IBS)
A noncontagious, periodic inflammation of the intestinal wall characterized by
chronic leukocyte infiltration of this wall. Symptoms include cramping, diarrhea,
weight loss and intestinal bleeding. Crohn’s disease is more serious, with deep
ulcers and fissures developing along the entire intestine. Ulcerative colitis is
characterized by a shallow inflammation of the mucosa of the large intestine,
mainly in the rectum. It is an abnormal immune and inflammatory response to
bacterial antigens. Treatment is a diet low in fiber and dairy, reducing stress, taking
antibiotics and anti-inflammatory and immunosuppressant drugs.
Cystic Fibrosis and the Pancreas
CF disrupts secretions in the respiratory system, but most of the body’s other
secretory epithelia are affected as well. The pancreas and intestinal glands,
submandibular glands and bile ducts in the liver all become blocked with thick
secretions. Clogged ducts prevent pancreatic juices from reaching the small
intestine. As a result, fats and other nutrients are not digested or absorbed and the
feces are bulky and fat laden. Can be treated by administering pancreatic enzymes
with meals.
23.3a: The Liver
The liver has over 500 functions, including:
- Producing and secreting bile
- Receives substances absorbed by the intestines through portal circulation
- Processes and stores nutrients, minerals, glucose and glycogen; controls
when to put these into
blood.
- Detoxifies ingested toxins
Anterior Surface
The liver is divided into left and right lobes, separated by the falciform
ligament. Inferiorly, the
falciform ligament
turns into the
round ligament
(which is a remnant of the umbilical vein). Superiorly the falciform ligament
turns into the
coronary ligament
Superior Surface
The coronary ligament bends into the
triangular ligaments
(right and left)
Most of the liver is covered by visceral peritoneum, except for the
bare area
of the liver which is not covered by pericardium (directly touching diaphragm)
Two other lobes as well, more superiorly the caudate lobe and inferiorly the
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quadrate lobe
Posterior
The porta hepatis is where most of the major vessels and nerves enter and
leave the liver. The
portal triad
consists of the hepatic artery, hepatic portal
vein and common hepatic duct (formed by the fusing of the R and L hepatic
ducts)
Small branches of the portal triad are organized around hexagonal-shaped
liver lobules, surrounding a central vein. Radiating from the central verin are
plates of liver cells (
hepatocytes
). Blood percolates through the hepatocyte
plate via large capillaries called sinusoids. Cleaned blood reaches a central
vein in the middle of the lobule. Central veins drain into hepatic veins which
drain into the IVC.
Bile produced by hepatocytes is secreted into channels which merge to form
bile ducts. Bile ducts form left and right hepatic ducts and these ducts form
the common hepatic duct at the porta hepatis.
Autonomic nerves come from the celiac plexus and consist of both
sympathetic and parasympathetic fibers. Other important structures on the
visceral surface are the gallbladder and IVC.
Clinical Application:
Cirrhosis
Cirrhosis is the progressive inflammation of the liver, usually as a result of
chronic alcoholism. The alcohol poisoned hepatocytes are continuously
replaced, the liver's connective tissue regenerates faster, so the liver
becomes fibrous and fatty, and its function declines. The scar tissue impedes
blood flow causing portal hypertension. As toxins accumulate the patient will
notice effects.
23.3b: The Gallbladder
The gallbladder stores and concentrates the liver’s bile. The gallbladder has a
fundus, body and neck. The gallbladder’s
cystic duct
joins the
common hepatic
duct
to form the
bile duct
which then empties into the duodenum. The liver
secretes bile continuously but sphincters at the end of the bile duct and
hepatopancreatic ampulla are closed when bile is not needed for digestion.
Clinical Application:
Gallstones
Bile is the normal vehicle in which cholesterol is excreted from the body, and bile
salts keep the cholesterol dissolved within bile. Too much cholesterol or too few bile
salts can lead to crystallization of cholesterol in the gallbladder producing gallstones
that can plug the cystic duct and cause pain.
23.3c: The Pancreas
The pancreas is both an exocrine and endocrine gland. In its endocrine function it
secrete insulin and glucagon, which lower and raise blood sugar levels. The exocrine
function is to produce most of the enzymes used in digestion within the small
intestine.
The pancreas is retroperitoneal, shaped like a tadpole and has head, body and tail,
neck and uncinate process (hook-shaped projection of head of pancreas). The tail
extends to touch the spleen and the head lies in the c-shaped curve of the
duodenum.
Exocrine Histology
Most of the pancreas is
acinar cells
arranged in acini (sacs). Acinar cells make
pancreatic juice containing enzymes and bicarbonate. Enzymes are stored and
secreted as
zymogens
(inactive enzymes). Zymogens move from acinus via
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intralobular ducts to main pancreatic ducts. Zymogens are only active when they
reach an acidic environment.
Endocrine Histology
The endocrine pancreas comprises 5% of the cells and are arranged in
islets (of
Langerhans)
. These cells produce insulin, glucagon, and somatostatin. Islet cells
secrete these hormones directly into the bloodstream.
Main Pancreatic Duct:
carries pancreatic juice from the pancreas to the
duodenum. Joins with the bile duct and together they make the
hepatopancreatic
ampulla (of Vater)
. The
hepatopancreatic sphincter (of Oddi)
surrounds the
duct and controls the flow of bile and pancreatic juice into the duodenum.
Hormones produced by the stomach and duodenum relax this sphincter and
promote contraction in the pancreas and gallbladder, enabling the entry of bile and
juice. The hepatopancreatic ampulla drain into the duodenum at major duodenal
papilla. There is often an
accessory duct
that enters separately into the duodenum
at the minor duodenal papilla.
The pancreas receives blood through branches of the hepatic, splenic and superior
mesenteric vessels. Its autonomic nerves are from the celiac plexus. Sympathetic
input derives from the thoracic splanchnic nerves, whereas parasympathetic input is
from the vagus nerve.
Clinical Application:
Pancreatitis
Inflammation of the pancreas. Typically accompanied by necrosis of pancreatic
tissue. Painful condition that usually arises from the blockage of the pancreatic duct.
The blockage results in activation of the pancreatic enzymes in the pancreas
instead of the small intestine. Can lead to nutritional deficiencies, diabetes,
pancreatic infections, etc
?
Week 10- Urinary System & Intro To Pelvic
Anatomy
The urinary system filters blood, eliminates waste, excretes excess ions and assists
in blood pressure/volume regulation (maintaining homeostasis)
24.1 Kidneys
The R kidney is crowded by the liver and lies slightly inferior to the left kidney. Each
kidney has a renal hilum where vessels, ureters, and nerves enter and leave the
kidney. The adrenal gland is on the superior part of each kidney.
Several layers of supportive tissue surround each kidney. The fat layers cushion the
kidney against blows and help hold the kidneys in place.
- The innermost layer is the f
ibrous capsule
that adheres directly to the
kidneys. The fibrous capsule helps maintain shape and forms a barrier that
can inhibit the spread of infection from the surrounding regions.
-
Perirenal fat
; protect and cushion
- An envelope of
renal fascia
that anchors kidney and adrenals in abdomen
-
Pararenal fat
; protect and cushion
There are two distinct regions of kidney tissue: cortex and medulla. Deep to
the cortex is the medulla which consists of cone-shaped masses called renal
pyramids. Renal columns separate adjacent pyramids. The renal sinus is a
large space within the medial part of the kidney opening to the exterior
through the hilum. The renal pelvis is the expanded superior part of the
ureter. Branching extensions of the renal pelvis form two or three major
calices each of which divides into minor calices. The calices collect urine
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draining from the papillae and empty it into the renal pelvis. Urine flows
through the renal pelvis and into the ureter which transports it to the bladder
for storage.
Papilla
→
minor calyx
→
major calyx
→
renal pelvis
→
ureter
The kidneys receive blood via the renal arteries. The right renal artery is
longer than the left because the aorta lies slightly left of the body midline. As
each renal artery approaches the kidney it divides into five segmental
arteries that enter the hilum. These further divide into interlobar arteries. The
veins follow the same pathway in reverse. The renal vein exits at the hilum
and empties into the IVC. The left renal vein is longer than the right because
the IVC lies on the right side of the vertebral column.
Innervation comes from the renal plexus (an offshoot of the celiac plexus).
The renal plexus is supplied by sympathetic fibers from the most inferior
thoracic splanchnic nerve, the first lumbar splanchnic nerve and other
sources.
Polycystic Kidney Disease
:
- Autosomal dominant trait. Can have single or multiple cysts and is often
associated with renal failure. To treat, the kidney is typically left in the body and the
transplanted kidney goes into the pelvis.
Nephron
: Functional unit of kidney
1.
Renal corpuscle (glomerular capsule and glomerulus)
2.
Proximal convoluted tubule
3.
Nephron loop
4.
Distal convoluted tubule
5.
Collecting duct
24.2 Ureters
Urine, collected from the renal calices and emptied into the renal pelvis, leaves the
kidneys via the ureters. We see kidney stones get lodged in three places, the renal
pelvis, at the pelvic brim and the bladder entrance. The ureters enter the bladder at
a sharp angle which acts as a natural valve.
24.3 Urinary Bladder
The empty bladder has the shape of an upside-down pyramid with four surfaces and
four angles. The two posterolateral angles receive the ureters. At the bladder’s
anterior angle (apex) is a fibrous band called the
urachus
, the closed remnant of an
embryonic tube. The inferior angle (neck) drains into the urethra. In males, the
prostate, a reproductive gland, lies directly inferior to the bladder, where it
surrounds the urethra.
In the interior of the bladder, openings for the ureters and urethra define the
trigone
. Infections tend to persist in this region.
The arteries are branches of the internal iliac arteries. Veins draining the bladder
form a plexus on the bladder’s inferior and posterior surfaces that empties into the
internal iliac veins.
Nerves come from the pelvic splanchnic nerves (parasympathetic fibers), a few
sympathetic and visceral sensory fibers too.
The bladder has three layers. A mucosa with transitional epithelium and a lamina
propria which forms the inner lining of the bladder. The mucosal lining contains
rugae. There is a thick detrusor muscle layer. Contraction squeezes urine from the
bladder during urination. The outermost layer is the adventitia (for the lateral and
inferior surfaces). The superior surface is covered by parietal peritoneum.
24.4 Urethra
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The urethra drains urine from the bladder and conveys it out of the body. Consists of
smooth muscle and an inner mucosa. At the
bladder-urethra junction
, a
thickening of the detrusor forms the internal urethral sphincter. This is an
involuntary sphincter that keeps the urethra closed when urine is not being passed.
The
external urethral sphincter
surrounds the urethra within the urogenital
diaphragm. It is used voluntarily to inhibit urination. The female urethra is much
shorter than the male urethra. In females, the urethra is bound to the anterior wall
of the vagina by connective tissue. It opens to the outside at the external urethral
orifice. The male urethra has three named regions:
the prostatic urethra, the
intermediate part of the urethra and the spongy urethra
. The spongy urethra
passes through the entire penis and opens at the tip of the penis via the external
urethral orifice. Carries the ejaculate as well.
24.5 Micturition
Micturition is the act of emptying the bladder. Brought about by the contraction of
the detrusor muscle (assisted by the muscles of the abdominal wall). Controlled by
the brain and involves autonomic and somatic pathways. As urine accumulates
stretch receptors are activated which send sensory impulses through the visceral
sensory neurons to the sacral region of the spinal cord, and then up to a micturition
centre in the dorsal part of the pons. The neurons in the pons signal the
parasympathetic neurons that stimulate contraction of the detrusor which empties
the bladder. At the same time, the sympathetic pathways to the bladder which
would prevent micturition by relaxing the detrusor muscle are inhibited. The
somatic motor neurons to the urethral sphincter are also inhibited, relaxing the
muscle and allowing urine to pass through the urethra.
Pelvic Wall Muscles: piriformis and obturator internus Pelvic Floor Muscles:
Coccygeus
and
levator ani (iliococcygeus, pubococcygeus, puborectalis)
.
Perineum is
positioned tangential to the curve of the pelvic floor. Pudendal nerve? Urogenital
Diaphragm:
superior urogenital fascia, deep perineal pouch, perineal membrane, deep
transverse perineal membrane, external urethral sphincter, internal
pudendal vein and dorsal nerve of penis/clitoris, bulbourethral glands
(males only), compressor urethrae (females only), and urethrovaginal
sphincter (females only)
.
Perineum:
Superior urogenital fascia, deep transverse perineal muscle, perineal membrane,
bulbospongiosus (covering bulb of penis), ischiocavernosus (covering crus of
corpora cavernosus), Colles’ fascia. It is a diamond shaped region containing a
urogenital triangle and anal triangle. Several potential spaces exist formed by the
convoluted fascial arrangements.
Spaces:
Infraperitoneal space
Ischioanal fossa
Deep perineal pouch Superficial perineal pouch Subcutaneous tissue
Urogenital and Anal Triangles
Urogenital Triangle (anterior): ischiopubic rami and posterior border of urogenital
diaphragm Anal Triangle: Inferior borders of gluteus maximus and posterior border
of urogenital diaphragm
Anorectal Flexure - angle between the anal canal and rectum. The angle is
decreased by the contraction of the levator ani muscle.
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?
Week 11+12- Reproductive System
3:25 PM
In the male reproductive system, gonads/testes
→
ductoral system (duct of the
epididymis, the ductus deferens, the ejaculatory duct and the urethra)
→
sex glands
(seminal glands, prostate and bulbourethral) The female reproductive organs differ
in several important ways. In addition to producing eggs, the female reproductive
organs also prepare to support a developing embryo during pregnancy. Second, the
female organs undergo changes according to the menstrual cycle. The primary
female reproductive organs are the ovaries. The accessory ducts include the uterine
(fallopian) tubes, the uterus, and the vagina. The female external genitalia are
referred to as the vulva.
25.1a The Testes
Descent of the Testis: The gubernaculum shortens thereby pulling the testis into the
scrotum. The layers are continuous with layers of the abdominal wall.
-
Dartos muscle
(from subcutaneous fascia)(can wrinkle to bring closer to
bodyO
-
External spermatic fascia
(from external oblique)
-
Cremaster muscle
(from internal oblique)(responsible for elevation)
-
Internal spermatic fascia
(from transversalis fascia)
- Extraperitoneal fat
- Parietal layer of
tunica vaginalis
(tunica vaginalis is from peritoneum)
- Cavity of tunica vaginalis
- Visceral layer of tunica vaginalis
Inguinal Canal
: transversus abdominis and internal oblique (roof),
Aponeurosis of external oblique (anterior wall), Conjoint tendon and Inferior
epigastric artery (posterior wall), Deep ring (entrance), Superficial ring (exit).
The canal runs laterally to the deep inguinal ring. This is where the vas
deferens and testicular vessels enter the pelvic cavity.
An inguinal hernia is when the intestines pass through a patent tunica
vaginalis.
Vas Deferens
: Within spermatic cord and carries sperm. Connects testis with
the seminal vesicles and ejaculatory ducts.
Seminal Vesicles
: Join with vas deferens to form an ejaculatory duct.
Seminal secretions are rich in fructose and prostaglandins
Prostate Gland
: Contains urethra and two ejaculatroy ducts. Secretions are
rich in citric acid and enzymes and proteases.
Bulbourethral Glands
: lubricates urethra and neutralizes acidity.
Male Urethra
: bladder
→
prostatic urethra (contains ejaculatory ducts)
→
membranous urethra (contains bulbourethral glands)
→
penile urethra
- Testes is partially enclosed by tunica vaginalis (three layers).
- Tunica albuginea is a fibrous capsule around the testis that has septal
extensions which divide the
testes into lobules (this is where the seminiferous tubules are)
- Out of the testes: seminiferous tubules
→
rete testis
→
efferent ductules
that enter epididymis
(sperm mature here and are emptied into the duct of epididymis during
ejaculation)
- The urethra carries sperm from the ejaculatory ducts to the outside of the
body. Its three parts are
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the prostatic urethra in the prostate, the intermediate part of urethra in the
urogenital diaphragm and the spongy urethra in the pinis. The mucosa of the
spongy urethra contain urethral glands that secrete mucus to help lubricate
the urethra
Spermatic Cord:
Tube of fascia containing testicular vessels and nerves.
Inferiorly in the scrotum, superiorly runs through the inguinal canal.
25.1b Male Reproductive Ducts
After expulsion from the epididymis, the vas deferens (ductus deferens)
stores and transports sperm. Vas goes through the inguinal canal and lateral
abdominal wall to enter the pelvic cavity. Near the bladder its distal end
expands as
the ampulla of the ductus deferens
and joins with the
duct
of the seminal gland
to make the
ejaculatory duct
. The ejaculatory duct
runs within the prostate and empties into the prostatic urethra.
25.1c Accessory Glands
The glands produce the semen (sperm plus secretions of the accessory
glands and accessory ducts). The
seminal glands
lie on the posterior
surface of the bladder. A thick layer of muscle surrounds the mucosa and
contracts during ejaculation to empty the gland. The secretions of the
seminal glands constitute 60% of the semen volume. It includes fructose and
other nourishment for the sperm, prostaglandins which stimulate the
contraction of the uterus to help move sperm through the female
reproductive tract, substances that suppress the immune response against
semen in females, substances that enhance sperm motility, enzymes that
clot the ejaculated semen in the vagina and then liquefy it so
the sperm can swim out. Sperm and seminal fluid mix in the ejaculatory duct and
enter the prostatic urethra together.
The
prostate glands
constitute about 1
⁄
3 of the volume of semen. It also contains
various substances to increase sperm motility and enzymes that clot then liquify
ejaculated semen.
The
bulbourethral glands
are small and inside the urogenital diaphragm. They
produce a mucus that enters the spongy urethra when a man becomes sexually
excited prior to ejaculation. It neutralizes any trace of acidic urine and lubricates the
urethra
25.1d The Penis
The penis delivers sperm into the female reproductive tract. The penis consists of
an attached root and a free body that ends in a large tip (
glans penis
). There is
loose skin covering the penis (foreskin). Internally, the penis contains the
spongy
urethra
and three long cylindrical bodies of erectile tissue. The
corpus
spongiosum
is enlarged distally where it forms the
glans penis
and proximally
where it forms a part of the root called the bulb of the penis. The
corpora
cavernosa
makes up most of the mass of the penis. Their proximal ends in the root
are
crura of the penis
.
The sensory dorsal nerves are branches of the
pudendal nerve
from the sacral
plexus and the dorsal arteries are branches of the
internal pudendal arteries
from the internal iliac arteries
. Two dorsal veins lie in the dorsal midline and
drain all blood from the penis. A
deep artery
runs within each corpus cavernosum.
The autonomic nerves follow the arteries and arise from the
inferior hypogastric
plexus
in the pelvis.
The male sexual response has chief phases: erection and ejaculation. During sexual
stimulation, parasympathetic innervation dilates the arteries supplying the erectile
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bodies increasing the blood flow to the vascular spaces within. Swelling occurs.
There are strong muscular fibers that ensure the penis does not buckle of kink
during intercourse. Erection is under parasympathetic control, ejaculation is under
sympathetic control. Begins with muscle contraction and causes constriction of the
internal urethral sphincter.
Penile Neurovasculature
- Dorsal nerve of the penis (sensations)(branch of pudendal nerve)
- Deep dorsal vein of the penis
- Dorsal artery of the penis (branch of internal pudendal artery)
- Deep (cavernous) artery of the penis
- Helicine artery
25.1e The Male Perineum
Contains the scrotum, the root of the penis and the anus. The floor is formed
by the muscles of the urogenital diaphragm and the superficial perineal
space.
Female Pelvic Organs and Genitalia
Female Pelvic Organs
- Ovary
- Fallopian Tube (fimbriae, infundibulum, ampulla, isthmus)
- Uterus
- Rectum
- Bladder
- Urogenital diaphragm
Vagina
: Tubular fibromuscular pelvic organ (the fornix is the circumferential
recess around the cervix. Orientation of the Uterus:
Angle of Version: uterine axis and axis of vagina Angle of Flexion: uterine axis
and cervical axis Ante-: acute angle (of version or -flexion) Retro-: Obtuse
angle (of version or -flexion) Typically we see anteverted anteflexed uterus’
Menstruation and Hormone Cycles:
- LH and FSH surge induce ovulation after rising estrogen levels.
- Progesterone rises from the remaining corpus luteum which stimulates
growth of the functional
layer of endometrium.
- If no fertilization, progesterone drops, inducing shedding of the functional
endometrium
Pregnancy
Implantation of the embryo causes the release of hCG that supports the
corpus luteum (keeps progesterone levels from falling) until the placenta
develops (placenta then produces progesterone). Hysterosalpingography:
contrast medium injected into the uterus. Used to determine patency.
Tubal Ligation: surgical method of birth control. Uterine tubes are cut,
cauterized or clipped to prevent joining of egg and sperm.
Uterine ligaments:
Peritoneal Folds:
Broad Ligament: mesovarium, mesosalpinx, mesometrium
Suspensory ligaments Developmental Remnants:
Ovarian ligament and round ligament Endopelvic Fascia
- The hypogastric sheath is the unified origin of the two (female) or three
(male) fascia septa.
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- Loose areolar endopelvic fascia fills the space between the more
ligamentous fascia septa
- Some special parts have their own names to emphasize a specific purpose
Components: lateral ligament of the rectum, cardinal (transverse cervical)
ligament, lateral ligament of the bladder.
Uterosacral ligament (constituent of the cardinal ligament), pubocervical
ligament (constituent of the lateral ligament of the bladder), pubovesical
ligament (constituent of the lateral ligament of the bladder).
- The cardinal ligament and uterosacral ligament form a sling (true
supporting ligaments of the uterus and bladder). The pubocervical fascia form
a nice wrap. If damaged during childbirth the uterus can invert and fall.
- Several ligaments and mesenteries help hold the uterus in place. The
mesometrium anchors to the lateral pelvic walls. Inferiorly, the transverse
cervical (cardinal) ligaments run horizontally from the cervix and superior
vagina to the lateral pelvic walls. The uterus is bound to the anterior body
wall by the paired round ligaments of the uterus. Despite the ligaments the
uterus is supported chiefly by the pelvic floor muscles (namely the muscles or
the urogenital and pelvic diaphragms). If these muscles are torn during
childbirth the uterus can sink
Vestibular Glands
- Secrete mucus into the vestibule. The greater vestibular glands have
increased secretions during sexual arousal (PSNS). The lesser vestibular glands
secrete with orgasm (PSNS) and have potential anti-microbial function.
Clitoris
: Innervation by the dorsal nerve of the clitoris (from pudendal nerve).
Has a crus, angle, body and glans.
25.2a The Ovaries
- Held in place by mesenteries and ligaments from the peritoneum (broad
ligament, suspensory ligament (ovary to lateral pelvic wall), ovarian ligament
(ovary to uterus)
- Ovarian arteries and uterine arteries. Reach ovary by travelling within the
suspensory ligament
- Innervation by sympathetic and parasympathetic nervous system
- Surrounded by tunica albuginea (covered by germinal epithelium). Ovary is
divided into the outer
cortex (houses oocytes) and inner medulla. The deep ovarian medulla
contains the largest vessels
and nerves; enter through the hilum.
- Ovary Internal Structure: Primordial follicle
→
primary follicle
→
secondary
follicle
→
tertiary
follicle
→
ovum
→
developing corpus luteum
→
corpus luteum
→
degenerating corpus luteum
25.2b The Uterine Tubes (AKA fallopian tubes)
- Receive ovulated oocyte and are the site for fertilization
- Infundibulum opens into the peritoneal cavity (to capture oocytes). Has
fimbriae that drape the
ovary. Largest section of the tube is the ampulla (fertilization usually occurs
here). Final third is
the isthmus
- The tube is covered by peritoneum and supported by an offshoot of the
broad ligament.
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- Ectopic pregnancies usually occur in the tubes.
25.2c The Uterus
- Receives, retains and nourishes fertilized egg (egg enters at the fundus)
- Divided into the body, isthmus (narrow neck), and cervix (continuation of
narrow neck)
- Cervical canal secretes a mucus that blocks the spread of bacteria from
vagina to uterus and
blocks sperm, except at midcycle.
- From outer to inner wall: perimetrium (serous membrane)
→
myometrium
(smooth muscle that
contracts during childbirth)
→
endometrium
- The endometrium has two chief layers: the functional layer and the basal
layer. The thick,
inner functional layer is shed and undergoes changes as a result of varying
levels of hormones in the blood. The thin basal layer is not shed and is
responsible for forming a new functional layer after menstruation ends.
- Blood supply from uterine arteries
25.2d The Vagina
- Anterior to rectum; posterior to urethra
- Wall has three coats: adventitia
→
muscularis
→
inner mucosa (marked by
rugae that stimulate
penis during intercourse)(has lamina propria that allow vagina to return to
original shape and
stratified squamous epithelium to resist friction and bacteria
25.2e The External Genitalia and Female Perineum
- Overall external genitalia is the vulva
- Mons pubis: fatty, rounded pad overlying the pubic symphysis
- Labia: majora (encloses) labia minora (encloses vestibule)
- Vestibule: houses the opening of the urethra and vagina. The vaginal orifice
is posterior to urethra orifice. Lateral are the greater vestibular glands that
lubricate. Homologous bulbs of the vestibule lie along each side of the
vaginal orifice and directly deep to the bulbospongiosus muscle.
- Frenulum of the labia: formed by the coming together of the right and left
labia
- Clitoris: anterior to the vestibule. Body contains a paired corpora
cavernosa, which
continue posteriorly into crura
- Perineum is a region between the pubic arch (anteriorly), coccyx (posteriorly),
and ischial
tuberosities (laterally). Perineal body is in the exact center and is the insertion
point of most pelvic floor muscles.
Neural Control of Male Sexual Function
:
Point (parasympathetic) and Shoot (sympathetic). Erection has PSNS efferents.
Psychological stimuli or pudendal nerve (from penis sensation)
→
sacral spinal
cord
→
efferent PSNS
→
Nitric oxide
→
cGMP
→
vasodilation of cavernous
artery
→
erect
The nerves branch from the pelvic splanchnic nerves.
Ejaculation has SNS efferents, somatic efferents and PSNS efferents.
Afferent stimulation (pudendal nerve) which makes its way to the spinal
ejaculation generator and consists of two phases.
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Sympathetic Nuclei
→
leads to smooth muscle contraction of bladder neck
which functions for expulsion and the seminal vesicles, prostate gland and vas
deferens which have seminal emission
Parasympathetic nuclei
→
epithelial secretions from prostate gland and seminal
vesicles (seminal emission)
Onuf’s nuclei
→
rhythmic contractions of bulbospongiosus and
ischiocavernosus (expulsion)
Sympathetic Outflow: in the sympathetic trunk postganglionic sacral splanchnic
nerve exits and goes to genitals and urinary bladder. Also from the trunk,
preganglionic lumbar splanchnic nerves go to the infrarenal ganglia (of the
aortic plexus) and synapse. The postganglionic then travels to the superior
hypogastric plexus that then goes to the genitals and urinary bladder.
Autonomic Outflow: Superior hypogastric plexus (SNS from aortic plexus, PSNS
from pelvic splanchnic nerve)
→
left hypogastric nerve, sacral splanchnic nerve
(SNS) (goes to inferior hypogastric plexus), pelvic splanchnic nerve (PSNS).
Phase one: Seminal Emission
Psychological stimuli or dorsal nerve of penis (and then the pudendal nerve)
→
lumbosacral spinal cord
→
Lumbar SNS and Sacral PSNS
→
Smooth muscle
contraction of the prostate, seminal vesicles and vas deferens transports
semen into the proximal (prostatic) urethra.
Phase two: Expulsion
1. Semen in the proximal urethra 2. Dorsal nerve of penis
Internal pudendal nerve (visceral afferents)
→
lumbosacral spinal cord
→
lumbar SNS (internal urethral sphincter contracts) OR pudendal nerve
(involuntary rhythmic contraction of the ischiocavernosus, bulbospongiosus
and other perineal muscles)
Internal Urethral Sphincter
1.
Semen enters prostatic urethra
2.
Internal urethral sphincter contracts (SNS)
3.
Forward flow ejaculation
4.
Internal urethral sphincter is paralyzed (open, loss of SNS)
5.
Backwards flow ejaculation
Neural Control of Female Sexual Function
Arousal: PSNS efferents
Orgasm: SNS efferents, somatic efferents, PSNS efferents. Arousal pathway:
1.
Psychogenic or other erogenous stimuli to sacral spinal cord OR dorsal nerve
of clitoris to pudendal nerve to sacral spinal cord
2.
Pelvic splanchnic nerve (efferent PSNS)
3.
Nitric oxide that leads to vasodilation of cavernous and vaginal artery OR
vaginal lubrication by
greater vestibular glands.
Sexual Refractory Period:
Males experience significant inhibition following ejaculation. The refractory
period in females is far less prominent, owing to the ability of multiple orgasms
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Find the domain of…
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solution is required to neutralize 13.4 mL of a
0.176 M…
Q: 1A
8A
3A 4A 5A 6A 7A He
Li Be
BCN
O F Ne
Na Mg 3B 4B 5B 6B 7B8B
18 2B Al Si P
S
Cl Ar
K Ca Sc Ti V…
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y (4)-2y"+y=xe
A) There is duplication with the complementary…
Q: QUESTION
36
In regression analysis, an outlier is an observation whose
O a. mean is larger than the…
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10
find f(x)dx
10
[
0
f(x) dx =
A=12
B=5
10
C-6
15
Q: Problem 3 (The Shell)
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Which character?
Suppose that the command cat filel…
Q: Draw the Lewis structure of each ion. Do not include formal charges. Then, determine the…
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Q: 5.Indicate the amino acid as polar or nonpolar
OH
CH, O
H₂N-C-C-OH
H
CH: O
H₂N-C-C-0
H
CH3 CH₂
CH…
Q: bo-
ΑΩ
10 mH
60 Ω
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'60 Ω
:30 μF
Calculate the equivalent impedance seen at the open terminals of…