2024_ProblemSet_1(1)

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Feb 20, 2024

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1 Problem Set #1 Monday January 29 th 2024 1. The following pedigree shows the inheritance of attached earlobes (black symbols) and unattached earlobes (open symbols). Both alternate phenotypes are quite common in human populations. If the phenotypes are determined by alleles of one gene, then attached earlobes are inherited as 2. A phenotypically normal woman is a carrier of the recessive allele that causes phenylketonuria (PKU). What proportion of her eggs will carry the allele that allows normal processing of phenylalanine? 3. A couple in Indiana are each heterozygous for the autosomal recessive allele for albinism. They have two children. What is the probability that both children will be phenotypically identical with regard to skin color? 4. If you had a fruit fly ( Drosophila melanogaster ) that was of phenotype A, what test would you make to determine if the fly’s genotype was A/A or A/a ? 5. Two black guinea pigs were mated and over several years produced 29 black and 9 white offspring. Explain these results, giving the genotypes of the parents and the progeny. 6. In a fungus with four ascospores, a mutant allele lys-5 causes the ascospores bearing that allele to be white, whereas the wild-type allele lys-5 + results in black ascospores. (Ascospores are the spores that constitute the four products of meiosis.) Draw and ascus from each of the following crosses: a. lys-5 x lys-5 + b. lys-5 x lys-5 c. lys-5 + x lys-5 + 7. From a large-scale screen of many plants of collinsia grandiflora, a plant with three cotyledons was discovered (normally there are two cotyledons). This plant was crossed with a normal pure-breeding wild-type plant, and 600 seeds from this cross were planted. There were 298 plants with two cotyledons and 302 with three cotyledons. What can be deduced about the inheritance of three cotyledons? Invent gene symbols as part of your explanation. BIL250 Problem Set #1 Dr. Alex Wilson

2 8. In the pedigree below, the black symbols represent individuals with a very rare blood disease. If you had no other information to go on, would you think it is more likely the disease is dominant or recessive? Give your reasons. 9. The pedigree below was obtained for a rare kidney disease. a. Deduce the inheritance of this condition, stating your reasons. b. If persons 1 and 2 marry, what is the probability that their first child will have kidney disease? BIL250 Problem Set #1 Dr. Alex Wilson

3 10. Consider the accompanying pedigree of a rare autosomal recessive disease, PKU. a. List the genotypes of as many of the family members as possible. b. If persons A and B marry, what is the probability that their first child will have PKU? c. If their first child is normal, what is the probability that their second child will have PKU? d. If their first child has the disease, what is the probability that their second child will be unaffected? [Assume that all people marrying into the pedigree lack the abnormal allele] 11. The pedigree below concerns a certain rare disease that is incapacitating but not fatal. a. Determine the most likely mode of inheritance of this disease. b. Write the genotype of each family member according to your proposed mode of inheritance. c. If you were this family’s doctor, how would you advise the three couples in the third generation about the likelihood of having an affected child? BIL250 Problem Set #1 Dr. Alex Wilson

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