BLOCK 3 Physio- Practice Exam Adjusted

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Dec 6, 2023

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Block 3 Practice Exam 1. What can be expected to occur after the administration of hypertonic NaCl into the plasma compartment? a. Extracellular volume increases, intracellular volume increases, osmolality increases b. Extracellular volume increases, intracellular volume decreases, osmolality decreases c. Extracellular volume increases, intracellular volume decreases, osmolality increases d. Extracellular volume decreases, intracellular volume increases, osmolality decreases 2. Liddle Syndrome leads to an unregulated sodium pump channel in the membrane of cells leading to a higher sodium reabsorption in the kidney of this individual. Which of the following would likely be true about this individual? i. They will have an increased ECF compared to normal ii. They will have increased ICF compared to normal iii. They will have decreased ICF compared to normal iv. They will have increased ECF compared to normal a. I, III b. II, III c. I only d. III only e. II only f. IV only 3. A person is running a marathon and has become dehydrated due to sweating. Assuming sweat is isotonic, which of the following would show the correct volume change in each of his compartments? a. b. c.
d. 4. According to a Darrow-Yanet diagram, normal fluid compartment values are as follows: a. 14L ICF, 28L ECF, 300mOsmoles/L b. 12L ICF, 30L ECF, 285mOsmoles/L c. 28L ICF, 14L ECF, 300mOsmoles/L d. 30L ICF, 12L ECF, 285mOsmoles/L 5. Researchers inject radio-labelled albumin into a rat and then dissect its kidney to determine distribution of blood flow throughout the kidney. If the rat was otherwise healthy, where would scientists find the largest amount of this radio-labelled albumin protein? a. The inner medulla b. The cortex c. The outer medulla d. The proximal tubule 6. Scientists want to breed a mutant rat that demonstrates a high GFR for research purposes. Which of the following changes would allow them to accomplish that? a. Genetically modifying the rats to express an increased diameter of their efferent arteriole b. Decreasing the expression of P-cadherin on the podocytes that keeps them connected to the basement membrane c. Activating genes to increase albumin production in the liver d. Genetically altering heart formation to decrease the size of the left ventricle 7. A patient presents with hypertension and the doctor decides to check his kidney function by determining his urine creatinine over 24 hours. If urine flow rate and plasma creatinine concentrations are within normal limits, but the patient is excreting an elevated amount of creatinine, what can be inferred about this information? a. The patient’s GFR is lower than usual and indicates kidney failure b. The patient’s GFR is higher than usual and indicates decreased kidney filtration compared to normal c. The patient’s GFR is lower than usual and indicates increased kidney function d. The patient’s GFR is higher than usual and increased kidney filtration compared to normal 8. The following values below were measured from a human subject to determine his kidney function. Find the renal plasma flow: Inulin clearance 135 ml/min Hematocrit 40% of RBF volume Renal blood flow 1200 ml/min
Clearance of PAH 648 ml/min a. 800 ml/min b. 135 ml/min c. 720 mL/min d. 480 ml/min 9. Using the data in the table above, determine the filtration fraction for this patient a. 20 % b. 18.75 % c. 11.25% d. 16.87% 10. ADH would lead to all of the following effects except: a. Increased osmolarity of the urine in the interstitial medullary b. Increased reabsorption of sodium and chloride c. Increased activity of the counter-current multiplier system d. Increased concentration of urea in the urine 11. A mutation leads to the loss of expression of genes that form principal cells. What would occur to a person with this mutation if they are injected with ADH? a. Increased expression of Na/Cl/K transporters in the thick ascending limb b. Hypertonic urine c. The lack of principal cells would lead to decreased bicarbonate reabsorption d. Increased movement of water into the interstitial space 12. A mutation causes increased expression of tight junctions between the cells in the late proximal tubule causing decreased solute permeability in the paracellular pathway. Given this issue, what would occur to the interstitial space adjacent the late proximal tubule? a. Na+ and Cl- movement into the interstitium will increase by 1/3 compared to normal b. Na+ and Cl- movement into the interstitium will decrease by 2/3 compared to normal c. Na+ and Cl- movement into the interstititum will increase by 2/3 compared to normal d. Na+ and Cl- movement into the interstitium will decrease by 1/3 compared to normal 13. Gatorade is an isotonic solution of mostly NaCl. An athlete who drinks this solution after hours of rigorous exercise and sweating would have what effect on his compartment volumes? a. The ICF volume would increase without change to the ECF volume b. The ICF volume would increase and the ECF volume would decrease c. The ECF volume would increase and the ICF volume would decrease d. The ECF volume would increase without change to the ICF volume e. ICF and ECF compartment volumes would increase by 2/3 and 1/3 respectively 14. A 28-year-old man with a history of alcoholism presents with jaundice and ascites. His condition worries the physicians as they fear he has suffered severe liver failure. After
physical exam, his blood pressure is taken and found to be lower than usual. Which of the following are likely contributing to his low blood pressure secondary to hypovolemia? I. Liver damage yields decreased production of angiotensinogen II. Liver damage yields decreased production of ADH causing hypovolemia III. Liver damage caused decreased production of albumin and lower osmotic pressure IV. The build-up of bilirubin due to liver damage directly decreases plasma sodium concentrations a. I only b. I and III c. II and IV d. I, II, and IV 15. A 65 y/o male is diagnosed with Type 2 Diabetes due to an increase in glucose excretion. To reduce glucose excretion, which one of the following would be the best compensation method? a. A b. B c. C d. D 16. A particular drug is synthesized to specifically re-route blood flow in the kidney. This drug increases blood flow to the medulla, while decreasing blood flow to the cortex. Which of the following patients would most likely benefit from taking this drug? a. A patient experiencing hypertension due to Liddle syndrome b. A patient with a posterior pituitary tumor c. The drug would not alter the electrolyte balance in a patient d. A patient experiencing hypotension due to hemorrhage 17. A 30-year-old man presents to his physician with concerns of dizziness, chest pain, and hypertension. His lab results showed high serum concentrations of sodium and a blood pH of 7.6. All of the following could also be true regarding his condition except: a. The man has increased secretion of protons in his urine b. The man has increased expression of EnaC channels in the membrane of his thick ascending tubule
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