Self-assesment Ch6

1. What are some of the medical applications of karyotyping? GENETICS syndrome? Down syndrome? 2. What kind of chromosomal aberration is exhibited by individuals with cri-du-chat V. Questions: tet are some of the medical applications of karyotyping? 1. 3. What are other types of chromosomal aberrations? List examples for each type. 4. For a couple, what is the significance of knowing chromosomal aberrations? What environmental factors may increase incidence of chromosomal abnormalities? Name at least three.

13. A dominant x-linked allele (B) gives normal color vision but the recessive allele (b) causes red-green color blindness.A.     What is the genotype of a man with normal color vision whose father was color- blind? B.     What is the genotype of a woman with normal color vision whose father was color-blind? C.     If a woman who is colorblind marries a man with normal vision, what would you expect for the genotypes and phenotypes of their children?   D.     If a man is color-blind, which parent did he inherit the gene from? Explain your answer. E.     Which parent does a man get all his x-linked genes from? F.     If a woman is color-blind, what do you know about the genotypes and phenotypes of her parents?   G.     Are men more likely than women to get a genetic disease which is x-linked and dominant? Are they more likely to get a disease that is x-linked and recessive? Explain your answers.   H.    Can a man with normal color vision have a colorblind daughter? Explain your answer.…

5. Red-Green colour blindness is inherited as an X-linked recessive trait in humans. A woman, who’s mother had red-green colour blindness marries a colour blind man. What are the chances that their child will be: 1. a colour-blind male? 4. a normal male? 2. a colour blind female? 5. a normal female? 5. The couple has a colour blind male child. What are the chances that their next child will be a normal female?

12.     Hemophilia is an x-linked disease in which the blood does not clot normally; it is sometimes called “bleeder’s disease.” Hemophilia is caused by a recessive allele (h). The dominant allele (H) produces blood that clots normally. A.    What is genotype of a man who is a hemophiliac? B.    What is the genotype of a man with normal blood clotting? C.    What is the genotype of a woman with normal clotting blood if her father was a hemophiliac? D.    If a man with normal clotting blood and a heterozygous woman have children together, what would you expect for the genotypes and phenotypes of the children?

1. What are the characteristics of X-linked recessive inheritance? 2. Why does a son never inherit his father’s defective X chromosome? 3. What is required for a woman to display a sex-linked recessive trait?

2. Imagine that you are in your late 30s or early 40s and decide that you want a child. You realize that you’re at greater risk of having a child with Down’s Syndrome. What sorts of genetic screening are available today? If you find out that this child has this condition, do you think it’s appropriate to have an abortion? Why or why not? Question: Does elective abortion of fetuses with physical or other developmental disabilities have an effect on the perception of personhood, dignity, and rights in society? Explain.

.Certain forms of human color blindness are inherited as X-linkedrecessive traits. Hemizygous males are color-blind, but heterozygous females are not. However, heterozygous females sometimeshave partial color blindness.A. Discuss why heterozygous females may have partial color blindness.B. Doctors identified an unusual case in which a heterozygousfemale was color-blind in her right eye but had normal colorvision in her left eye. Explain how this might have occurred.

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1. Hemophilia is a disease inherited as a X-linked recessive trait while pattern baldness is controlled by an autosomal gene that is dominant in males and recessive in females. A hemophilic man who is also homozygous for baldness has children with a woman who is not hemophilic but a carrier and heterozygous normal-haired. Show the parental genotypes, the Genotypic ratio (GR) of the offspring and their phenotypic ratio. Separate the total number of the male offspring from female offspring. For example, if there are 8 total number of offspring, count how many are females and how many are males. So if there are 4 females, then the denominator for the genotypic ratio and phenotypic ratio for female offspring is 4. You can convert it to percentage if you want. Answer the following: a. Among the female offspring, what is the probability of having hemophilic but normal haired child? b. Among the male offspring, what is the chance of having a child with normal blood clotting but bald?

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5. A husband and wife have typical vision, although both of their fathers are red-green colorblind (an X-linked recessive trait). From this information, determine the appropriate symbols for the wild-type and color-blind alleles and write the genotypes of the husband and wife. a. b. What is the probability that the couple will have a son with typical vision? C. What is the probability that the couple will have a daughter with typical vision? d. What is the probability that the couple will have a son with colorblindness? e. What is the probabilityt the the couple will have a daughter with colorblindness?

3. Practice: Cross a wild female with a male that has white eyes and a tan body. recall from the exercise that both these traits are x-linked traits. provide p-generation genotype, Punnett squares cross, phenotypic, and genotypic ratios.

What percentage of all children will be carriers? What is the sex of the carriers? 2. A heterozygous woman carrying the recessive gene for hemophilia marries a man who is not a hemophiliac. Assume the dominant gene is X" and the recessive gene is X". The woman's genotype is X"X", and her husband's genotype is X"Y. What is the potential percentage and sex of their offspring who will be hemophiliacs? % males; % females 100 What percentage can be expected to lack the allele for hemophilia? What is the anticipated sex and percentage of individuals who will be carriers for hemophilia? 2014 sex %,

1. In man, normal color vision vs. red green colorblindness is controlled by C (dominant) and c (recessive) at an X-linked locus. a. Can a normal daughter have a color-blind father? A normal father? A color-blind mother? A normal mother? b. Can two normal parents have a color-blind son? A color-blind daughter? c. Can two color-blind parents have a normal daughter? A normal son?

1. Hemophilia is due to a sex-linked gene. It is recessive and found on the X chromosome. A woman who is a carrier for hemophilia marries a normal man. What will be the possible phenotypes of their children? Use a punnet square. 2. A phenotypically normal man, who has a hemophiliac brother, marries a normal woman, who is not a carrier. What is the probability that any of their children will be hemophiliac? Use a punnet square. 3. Color-blindness is an X-linked, recessive trait. If a normal-sighted woman, whose father was color-blind, marries a colorblind man, what is the probability that they will have a son who is color-blind? Use a punnet square. 4. A man and woman, both of normal vision, have:  1) a color-blind son (#1) who has a daughter of normal vision  2) a daughter (#1) of normal vision who has one color-blind son and one normal vision son  3) another daughter (#2) of normal vision who has five sons, all with normal vision  What are the probable genotypes of the…

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A. B. 13. A dominant x-linked allele (B) gives normal color vision but the recessive allele (b) causes red-green color blindness. D. E. F. G. 9:24 H. C. If a woman who is colorblind marries a man with normal vision, what would you expect for the genotypes and phenotypes of their children? I. 2 .5G prairiestate.desire2learn.com What is the genotype of a man with normal color vision whose father was color- blind? What is the genotype of a woman with normal color vision whose father was color-blind? If a man is color-blind, which parent did he inherit the gene from? Explain your answer. Which parent does a man get all his x-linked genes from? D If a woman is color-blind, what do you know about the genotypes and phenotypes of her parents? Are men more likely than women to get a genetic disease which is x-linked and dominant? Are they more likely to get a disease that is x-linked and recessive? Explain your answers. Can a man with normal color vision have a colorblind daughter? Explain your…

1. Study the given alleles. Write the correct phenotype for each genotype. X – normal Gen otype xC - Color-blind Phenotype XX XY XXC xCY 2. Study the given alleles. Write the correct genotype for each phenotype. xH - Hemophiliac Phenotype X- normal Gen otype Hemophiliac female Hemophiliac male Normal female carrier of the gene Normal male Normal female 28 3. Determine the genotype and phenotype of the offspring. A color-blind mother (XCx) married a normal sighted (XY) father. Genotype: Phenotype: Genotype: Phenotype: Genotype: Genotype: Phenotype: Phenotype: a. There are b. There are c. There are d. There are % normal sons. % normal daughters. % color-blind sons. % color-blind daughters. % normal female, carrier of the disorder. or or or or e. There are or

9. Red-green color blindness is inherited as an X-linked recessive (Xc).  If a color-blind man marries a woman who is heterozygous for normal vision, what would be the expected phenotypes of their children with reference to this character?  In your answer, specify in your phenotype descriptions the gender of the children.  (For example, don’t just say 75% of the children would be colorblind – you would instead say 100 % of the daughters would be colorblind and 50% of the sons would be colorblind.  Note that this is not a correct answer; it is just to give you an idea of how to explain the correct phenotypes of the cross.)___

4. Marfan syndrome is a genetic trait caused by in a dominant allele. The trait causes a weakening of the aorta that can be fatal. A teenager whose mother has the syndrome (but whose maternal grandfather was not affected), and whose father was unaffected, is concerend that she may have the trait. a. What is the phenotype of each of her parents? Genotype? b. What is the chance that the teenager has Marfan syndrome?

14. Generally, X-linked recessive traits are not expressed in heterozygous females, and affect all the sons of a female carrier.   True   False

. Assuming no involvement of the Bombay phenotype(in case you’ve already read ahead to Section 3.2):a. If a girl has blood type O, what could be the genotypes and corresponding phenotypes of her parents?b. If a girl has blood type B and her mother has bloodtype A, what genotype(s) and correspondingphenotype(s) could the other parent have?c. If a girl has blood type AB and her mother is alsoAB, what are the genotype(s) and correspondingphenotype(s) of any male who could not be thegirl’s father?

5. Rather than studying you are watching Maury. A couple comes on with a baby. The father has brown eyes, his parents, grandparents, sister, and brothers all have brown eyes. The mother has blue eyes and the baby has blue eyes. The brown eye allele is dominant to blue eye allele. Using this information, answer the following questions. Co What is the likely genotype of the father? What is the genotype of the mother? What is the genotype of the child? Refi

16. A woman who is type O marries a man who is heterozygous for type A. What are the chances that they will have a type O baby? Tracking two traits. Now it's time to track two traits at the same time.

3. Short-tailed pup distribution. In mice, the dominant T allele results in a short tail. Homozygous T/T genotype is lethal, which means mouse embryos with this genotype die before they are born. Homozygous t/t is normal, with normal tail. A cross between two short-tailed mice produces a litter of 5 pups. a). What are the genotype(s) of the two short-tailed mice used in the cross? b). What are the possible genotypes and phenotypes of the 5 pups? What are their perspective ratio?