LYMPH AND IMMUNE SYSTEM WB OLA (6)
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The Lymphatic System and
Body Defenses
The lymphatic system, with its many lymphoid organs and vessels derived from veins of the cardiovascular system, is a rather strange system. Although both types of organs help to maintain homeostasis, these two elements of the lymphatic system have substantially different roles. The lymphatic vessels keep the cardiovascular system functional by maintaining blood volume. The lymphoid organs help defend the body from pathogens by providing operating sites for phagocytes and cells of the immune system.
The immune system, comprising the body's specific defense system
, is a unique functional system made up of billions of individual cells, most of which are lymphocytes. The sole function of this defensive system is to protect the body against an incredible array of pathogens. In general, these "enemies" fall into three major camps: (1) microorganisms (bacteria, viruses, and fungi) that have gained entry into the body, (2) foreign tissue cells that have been transplanted (or, in the case of red blood cells, infused) into the body, and (3) the body's own cells that have become cancerous. The result of the immune system's activities is immunity, or specific resistance to disease. The body is also protected by a number of nonspecific defenses provided by intact surface membranes such as skin and mucosae, and by a variety of cells and chemicals that can quickly mount an attack against foreign substances. The specific and nonspecific defenses enhance each other's effectiveness. Chapter 12 tests your understanding of the functional roles of the various lymphatic system elements, and both the
nonspecific and specific body defenses.
THE LYMPHATIC SYSTEM
Lymphatic Vessels
1
. Complete the following statements by writing the missing terms in the answer blanks.
1. 2. 3. 4. 5. 6. Although the cardiovascular system has a pump (the heart) and arteries, veins, and capillaries, the lymphatic system lacks two of these structures: the (1)
and (2)
. Like the (3)
of the cardiovascular system, the
vessels of the lymphatic system are equipped with (4)
to prevent backflow. The lymphatic vessels act primarily to pick up leaked fluid, now called (5)
, and return it to the bloodstream. About (6)
of the fluid is returned every 24 hours.
2
. Figure 12-1 provides an overview of the lymphatic vessels. In part A, the relationship between lymphatic vessels and the blood vessels of the cardiovascular system is depicted schematically. Part B shows the different types of lymphatic vessels in a simple way. Label these specific structures in part B:
A. Lymph capillaries
C. Lymphatic collecting vessels
E. Valves
B. Lymph duct
D. Lymph node
F. Vein
3. Highlight the term that does not belong in each of the following groupings.
1. Blood capillary Lymph capillary
Blind-ended
Permeable to proteins
2. Edema
Blockage of lymphatics
Elephantiasis
Inflammation Abundant supply of lymphatics
3. Skeletal muscle pump
Flow of lymph
Respiratory pump
High-pressure gradient
Action of smooth muscle cells in walls of lymph vessels
4. Minivalves
Endothelial cell overlap
Impermeable
Lymphatic capillaries
Lymph Nodes and Other Lymphoid Organs
4. Match the terms in Column B with the appropriate descriptions in Column A. More than one choice may apply
in some cases.
Column A
Column B
1. The largest lymphatic organ; a blood reservoir
A. Lymph Nodes
2. Filter lymph
B. Peyer’s patches
3. Particularly large and important during youth; C. Spleen
produces hormones that help to program the immune system D. Thymus 4. Collectively called MALT
5. Removes aged and defective red blood cells
E. Tonsils
6. Prevents bacteria from breaching the intestinal wall
5. Figure 12-2 depicts several different lymphoid organs. Label all lymphoid organs indicated by a leader line (red text boxes) and label (blue text boxes) the sites where the axillary, cervical, and inguinal lymph nodes
would be located.
Color the lymphoid organs as you like, and then shade in light green the portion of the body
that is drained by the right lymphatic duct (done).
6. Figure 12-3 is a diagram of a lymph node. First, using the terms with color coding circles, learn all structures in black labels on the diagram that have leader lines.
Color those structures as well. Then, add arrows to the diagram
to show the direction of lymph flow through the organ (done). Circle the region that would approximately correspond to the medulla of the organ (done
). Finally, answer the questions that follow.
1. Which cell type is found in greatest abundance in the germinal centers?
2. What is the function of their daughter cells, the plasma cells?
3. What major cell type in cortical areas other than the germinal centers?
4. The third important cell type in lymph nodes (usually found clustered around the medullary sinuses) are the _________________________________. These cells act as capsule
Afferent lymphatic
trabeculae
Subscapular sinus
cortex
Germinal center
Medullary sinus
medullary cord
hilus
Efferent lymphatics
5. Of what importance is the fact that there are fewer efferent than afferent lymphatics associated with lymph nodes?
6. What structures assure that one-way flow of lymph through the node?
7. The largest collections of lymph nodes are found in what three body regions?
8. What is the general function of lymph nodes?
BODY DEFENSES
Nonspecific Body Defenses
7. The three major elements of the body’s nonspecific defense system
are: the (1) , consisting of the skin and _____________________ ; defensive cells, such as (2) _____________________ and phagocytes; and a whole deluge of (3) _____________________ .
8. Indicate the sites of activity or the secretions of the nonspecific defenses by writing the correct terms in the answer blanks.
1.
Lysosome is found in the body
secretions
called and 2.
Fluids with an acid pH are found in the and 1.
2.
3.
3.
Sebum is a product of the glands and acts at the surface of the 4.
Mucus is produced by glands found in the respiratory and system mucosae.
9. Highlight the term that does not belong in each of the following groupings.
1.
Redness Pain
Swelling Itching
Heat
2.
Neutrophils
Macrophages
Phagocytes
Natural killer cells
3.
Inflammatory chemicals
Histamine
Kinins
Interferon
4.
Intact skin
Intact mucosae
Inflammation
First line of defense
5.
Interferons
Antiviral
Antibacterial
Proteins
10. Match the terms in Column B with the descriptions of the nonspecific defenses of the body
in Column A. More than one choice may apply.
Column A
Column B
1. Have antimicrobial activity
A. Acids
2. Provide mechanical barriers
B. Lysozyme
3. Provide chemical barriers
C. Mucosae
4. Entraps microorganisms
D. Mucus
entering the respiratory
E. Protein-digesting enzymes
passages
F. Sebum
5. Part of the first line of defense
G. Skin
11. Describe the protective role of cilia in the respiratory tract.
12. Define phagocytosis
.
1.
2.
3.
4.
5.
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Related Questions
Lymphocytes that develop immunocompetence in the thymus are __________lymphocytes.
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Lymphoid organs are divided into primary and secondary peripheral organs. Briefly
describe thymus gland and lymph node and their main role(s) in the immune system.
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Rt. And Lt. internal iliac veins
Rt. And Lt. external iliac veins
Internal and external iliac veins
Rt. And Lt. femoral veins
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The lymphatic tissues/organs illustrated below contain which of the following types of cells?
1. reticular cells
2. macrophages
3. B lymphocytes
4. T lymphocytes
Choose from the following:
(A) 1, 2 and 3
(B) 1, 2, and 4
(C) 2, 3, and 4
(D) 1, 3, and 4
(E) 1, 2, 3, and 4
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T lymphocytes are characteristically found in all of the following locations EXCEPT
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Which of the following statements is NOT TRUE about Macrophages?
Macrophages have a single, somewhat large nucleus and granular inclusions
Macrophages serve as antigen presenting cells or APCs
Macrophages can express both MHC I and MHC II when acting as an APC
Macrophages have less surface area than dendritic cells have, to bind antigens
Macrophages arise from the same cell as dendritic cells
Resident macrophages are found in only certain, specific tissues
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Which of the following structures defend against pathogens by acting as a blood filter?
lymph node
thymus
spleen
tonsils
red marrow
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Movement of large bulky substances into lymphatic vesses is easier and less selective than movement of these same
(1) tight junctions, and allow solute movement
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(2)
O More; Paracellularly
O Fewer; Paracellularly
O More; Transcellularly
O Fewer; Transcellularly
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Part E - Characteristics of Lymphocytes
Drag and drop the correct type of immunity on the left to complete the sentence that describes the targets, actions, or cell associated with that type of immunity. Immunity types may be used more than once, but each sentence has only one correct type of immunity associated with the description.
View Available Hint(s)
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Macrophage, dendritic cells, T-cells, and B-cells are all considered cells of the adaptive immune system. All these cells come in different varieties. Still there are some basic processes and interactions between them to generate the appropriate adaptive immune response and defeat the pathogen.
Which white blood cell above is not a phagocyte but is an antigen-presenting cell?
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antibodies
blood
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long-term
macrophages
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The presence versus the absence of macrophages and dendritic cells
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The mechanism by which antigens or pathogens enter the organ
The ability of naïve T cells to be activated and proliferate in the organ
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their maturation in the thymus and release into the circulation, T-
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Paracortex of lymph nodes
Red pulp of the spleen
O Cortical lymphoid nodules of lymph nodes
Hilus of lymph nodes
O Medullary cords of lymph nodes
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List the similarities and differences between the following terms: B lymphocyte and T lymphocyte
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True or False
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eosinophil
Immunoglobulin M
fibrin
lysozyme
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Which leukocytes above are professional antigen-presenting cells? How do they differentiate their work load?
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Which is not an effector T lymphocyte?
cytotoxic T lymphocyte
memory T lymphocyte
helper T lymphocyte
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Clinical Application: Immune System and Autoimmunity Disease
Lymphocytes may be involved in two major types of responses to the presence of potentially threatening foreign substances. In anti- body-mediated immunity, B lymphocytes may produce antibodies that react with specific antigens on an invading cell or molecule. In cell-mediated immunity, T lymphocytes secrete lymphokines that signal other immune responses and often destroy antigen- containing cells directly.
The antibody-antigen reactions associated with immune responses have been used by clinical biologists for years. Several examples are given. Think about each example and answer the questions.
1. Biologists often use antibodies to test for the presence of certain antigens in a particular substance. In Lab Exercise 33- Hormones and Lab Exercise 34-Blood, you witnessed demon- strations of this technique. For each antigen listed, indicate the substance tested (e.g., blood, urine) and give a brief summary of the…
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Match the formed elements with their functions:
Erythrocytes
thrombocytes
granulocytes
neutrophils
basophil
natural killer cells
Choices
nonspecific innate defense mechanisms
carry oxygen to tissues
seek out and destroy bacteria via phagocytosis
recognize and destroy abnormal host cells basophil releases histimine; function in allergic reactions and inflammation responses
formation of blood clots and tissue repair
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to contrast the difference between the adaptive and innate immune system. What cells are involved, which one is most specific and which one is responsible for long lasting immunity. Try to include as much detail as possible when contrasting these two arms of the immune system.
Requirements
be at least 150 words.
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- Lymphocytes that develop immunocompetence in the thymus are __________lymphocytes. We put everything in our mouth since our childhood. Therefore our mouth is full of live bacteria. These bacteria are potentially dangerous if they cross our gut wall into our blood circulation. Fortunately we are protected from them by our gut's mucosal lining and the cells (macrophages, dendritic cells, B and T lymphocytes) in the lymphoid tissue called [a] (enter two words). This structure play a crucial role for the development of food tolerance or food [b] (enter one word), coeliac disease and chronic inflammatory bowel disease.arrow_forwardLymphoid organs are divided into primary and secondary peripheral organs. Briefly describe thymus gland and lymph node and their main role(s) in the immune system.arrow_forwardThe tributaries of the common iliac vein would be: Rt. And Lt. internal iliac veins Rt. And Lt. external iliac veins Internal and external iliac veins Rt. And Lt. femoral veinsarrow_forward
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SEE MORE QUESTIONS
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