Lab 1

Benzoic acid and water were added to the test tube labeled "b.a." After stirring the mixture, sodium hydroxide (NaOH) vas added until the solid disappeared. Finally, hydrochloric acid was added drop by drop until blue litmus paper turned red. The solid present in the test tube after the addition of HCI is most likely: benzoic acid benzyl acetate O benzyl chloride sodium benzoate

b. When added to an immiscible mixture of dichloromethane and water, which layer would you expect the following compounds to primarily be found in? Explain. i. limonene CH3 CH3 CHM 2070 Lab Fall 2020 ii. acetic acid HOCH3 i. benzaldehyde

Please don't provide handwritten solution ...

You are employed as a coop student at the Drug and Alcohol Testing Association of Canada (DATAC) developing analytical tests for sports doping agents. You are asked to prepare a procedure for the extraction of methylphenidate, the active compound in Ritalin, from urine samples (consider them as simple aqueous layers, you do not need to consider other components!). The goal of the procedure is to extract the methylphenidate into an organic layer which will then be evaporated, and the residue will be tested for the drug.Your colleague is helping you develop the urine test. They suggest that the urine should be adjusted to a pH above 7 before extracting with the organic solvent. Why is this necessary? Support your explanation with a full arrow-pushing mechanism for the reaction that would occur if the pH was below 7. Include all formal charges, intermediates (if applicable) and products.

You are employed as a coop student at the Drug and Alcohol Testing Association of Canada (DATAC) developing analytical tests for sports doping agents. You are asked to prepare a procedure for the extraction of methylphenidate, the active compound in Ritalin, from urine samples (consider them as simple aqueous layers, you do not need to consider other components!). The goal of the procedure is to extract the methylphenidate into an organic layer which will then be evaporated, and the residue will be tested for the drug.You find that methylphenidate is highly soluble in 2-methyltetrahydrofuran, a bio-renewable solvent. Draw the structure of 2-methyltetrahydrofuran and give two reasons why it is a good solvent choice for liquid-liquid extraction.

а. ОН 1. TBSCI imidazole, CH2Cl2 A DMF, -18 °C to rt 2. NalO4, CH2Cl2 80% НО OH large excess

What is the main concern with trying to distill azeotropic mixtures?  options: 1- Specialized equipment is required, making separation expensive 2- There are no major concerns with distilling azeotropic mixtures. 3-The components become explosive at high temperature, making separation unsafe. 4- The boiling points of the components are too similar, making separation impractical. 5-The mixture will distill at a single temperature with a constant composition, making separation impossible

Need help ASAP!! thanks! The minimum volume of boiling water is used to dissolve 1.50 g acetanilide.  The hot solution is cooled to room temperature and the acetanilide recrystallizes.  What mass of acetanilide remains dissolved in water? (solubility of acetanile at 100o C is 5 g/100 mL and at room temperature is 0.54 g/100 mL). (Enter a number only with no g unit.)

Justify the solubility of the samples in the corresponding solvent based on their structure.   Sample                   water 5% NaHCO3 5% HCl 5%NaOH Conc. H2SO4 ether     Aniline                 n-butyl amine                 Acetic acid                 Phenol                 cyclohexanol                 2-Propanol                 Benzoic acid                 bromobenzene                 Ethylene glycol

10. Which of the below compounds are protic solvents? II II Al N-d-N HO-O H OH HO N. H3C H. Ethanenitrile (Acetonitrile) Ethane-1,2-diol (Ethylene glycol) Hexamethylphosphorotriamide Methanamide (Formamide) Methanol (HMPA) All are protic b. 1,1l and V are protic Il and IIII are protic a. d. 1, IV and V are protic е. All are aprotic C.

9. Determine whether the following drugs comply with Lipinski's rule. Also investigate the "alternative criteria" (rotatable bonds, polar surface area) for both drugs. OH N(CH3)2 HO. OH OH OH O Tetracycline (antibiotic) P=0.04 OH CONH₂ OH N. Naloxone (morphine agonist) P=83

10. Fractional Distillation: This lab was viewed via a video and described in detail in lab class. You are distilling apart hexane (bp = 68) and toluene (bp 110). Your boiling point for the first fraction is 48°C. Why is the boiling point so low (most likely reason)? !! azeotrope with water non-resonance of hexane O resonance of toluene student error O seriously impaired thermometer

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6. A nucleotide is the basic building block of nucleic acids. RNA and DNA are polymers made of long chains of nucleotides. A nucleotide consists of a sugar molecule (either ribose in RNA or deoxyribose in DNA) attached to a phosphate group and a nitrogen-containing base (the red nitrogen atom is connected to a sugar molecules). NH₂ adenine (A) HN. NH₂ NH (a) paired bases by hydrogen bonding. NH₂ HN HN cytosine (C) guanine (G) thymine (T) uracil (U) Which bases will make hydrogen-bonds together within an DNA? Draw structures of the (b) Which bases will make hydrogen-bonds together within an RNA? Draw structures of the paired bases by hydrogen bonding.

Kindly provide a CLEAR, COMPLETE and DETAILED solution. Answer it ASAP, thanks. Make your solution understable and readable. Answer #23 only

You are asked by your chemistry teacher to find: a) the solubility of different carboxylic acids in water and b) whether there is a connection between solubility and structure of different carboxylic acids. Follow the questions below to design and conduct an experiment to determine an answer to this question. a. From the paragraph above, write a question out that you will try and answer from conducting an experiment (C:2) b. Based upon your knowledge of the physical properties of organic compounds, hypothesize an order of solubility from lowest to highest: (1:3) Organic Compound Order of solubility (1=lowest, 3=highest) Pentanoic acid Hexanoic acid Ethanoic acid c. Provide an overall explanation for your hypothesis based upon your knowledge of physical properties. (A:3) d. Based upon the materials listed below, design a step by step experiment to test your hypothesis. Provide your individual steps. Include all the materials listed below. (1:3) Materials: CH,(CH,4COOH (), CH,COOH (),…

5. Give the definition of the inductive effect. What is the reason for its appearance in the molecule? Show the effect of the inductive effect in molecules: bromoethane CH3CH3B1; ethanol CH3CH2OH; fluoroethane CH3CH2F.

Part A The chemical 5-amino-2,3-dihydro-1,4-phthalazinedione, better known as luminol, is used by forensic scientists in analyzing crime scenes for the presence of washed-away blood. Luminol is so sensitive that it can detect blood that has been diluted 10,000 times. A basic solution of luminol is often sprayed onto surfaces that are suspected of containing minute amounts of blood. The forensic technician at a crime scene has just prepared a luminol stock solution by adding 15.0 g of luminol into a total volume of 75.0 mL of H2O. What is the molarity of the stock solution of luminol? Express your answer with the appropriate units. Luminol has a molecular weight of 177 g/mol. • View Available Hint(s) HẢ molarity of luminol solution = Value Units Submit Part B Before investigating the scene, the technician must dilute the luminol solution to a concentration of 6.00x10-2 M. The diluted solution is then placed in a spray bottle for application on the desired surfaces. How many moles of…

How do you prepare a 100mL solution of 5% acidified methanol?

What will be the solubility of the sugar if dissolved in 60 degrees celsius water?

Which of these solvents is polar protic? 1) Methanol 2) DMSO 3) DMF 4) ACN

Based on the informaton presented below, answer the following questions. An ether solution contains the following components. 2,3,4,5-tetramethylbenzene benzyl alcohol 2-hydroxybenzoic acid This solution is extracted with a 1.0 M solution of NaOH, that is immiscible with ether. The 2-hydroxybenzoic acid will be recovered from the layer.

d. 1) LDA OCH3 2) CH3CH2I е. 1) LDA 2) CH3I

Succinimide is an organic compound used in many syntheses as a building block and is related to a class of drugs known as anticonvulsants. Given the following solubility of succinimide in water and methanol, which would be a better solvent for recrystallizing succinimide? Solubility data: 1 gram of succinimide is soluble in 5 mL of cold water, 3 mL of water at room temperature and 0.7 mL of boiling water. 1 gram of succinimide is soluble in 30 mL of cold methanol, 24 mL of room temperature methanol and 5 mL of hot methanol. Show all calculations.

Dangerous Paint Stripper Jessica has a summer job working for the city parks program. She has been using a cleaner called “Graffiti Gone” to remove graffiti from the bathrooms. She has to take a lot of breaks, because the chemical makes her throat burn. It also makes her feel dizzy sometimes, especially when the bathrooms don’t have very many windows. On the label, she sees that the cleaner has methylene chloride in it. She feels like she’s managing to get the work done, but she is worried about feeling dizzy. She wants to find out more about this chemical, what harm it can cause, and whether there are safer ways to do this work. Questions for following story. 1. What went right in this situation? 2. What went wrong in this situation? 3. What steps should be taken in this workplace to make sure employees are better protected and prepared the next time?